“…Acetylshikonin, a major bioactive component of leaf extracts of L . erythrorhizon root (Gwon et al, 2012; Pietrosiuk et al, 2006; Zhao, Wu, Wu, Zhao, & Chen, 2016), exhibits various pharmacological activities including induction of autophagy, anti‐oxidative, anti‐inflammatory, anti‐proliferative, anti‐fertility, and anticancer effects (He, Li, Su, Huang, & Zhu, 2016; Pietrosiuk et al, 2006; Skrzypczak et al, 2015; Wu et al, 2011; Zeng, Zhu, & Su, 2018). Several studies have demonstrated that the compound inhibits growth of a variety of cancers, including colorectal, breast, liver, medullary thyroid carcinoma, pancreas, melanoma, and gastric cancers (Cho & Choi, 2015; Hasenoehrl et al, 2017; Kim, Lee, Park, & Choi, 2016; Kretschmer et al, 2012; Park et al, 2017; Vukic et al, 2017; Zeng, Liu, & Zhou, 2009).…”