2018
DOI: 10.1016/j.bbrc.2018.07.094
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Autophagy is involved in acetylshikonin ameliorating non-alcoholic steatohepatitis through AMPK/mTOR pathway

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Cited by 19 publications
(12 citation statements)
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“…Acetylshikonin, a major bioactive component of leaf extracts of L . erythrorhizon root (Gwon et al, 2012; Pietrosiuk et al, 2006; Zhao, Wu, Wu, Zhao, & Chen, 2016), exhibits various pharmacological activities including induction of autophagy, anti‐oxidative, anti‐inflammatory, anti‐proliferative, anti‐fertility, and anticancer effects (He, Li, Su, Huang, & Zhu, 2016; Pietrosiuk et al, 2006; Skrzypczak et al, 2015; Wu et al, 2011; Zeng, Zhu, & Su, 2018). Several studies have demonstrated that the compound inhibits growth of a variety of cancers, including colorectal, breast, liver, medullary thyroid carcinoma, pancreas, melanoma, and gastric cancers (Cho & Choi, 2015; Hasenoehrl et al, 2017; Kim, Lee, Park, & Choi, 2016; Kretschmer et al, 2012; Park et al, 2017; Vukic et al, 2017; Zeng, Liu, & Zhou, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Acetylshikonin, a major bioactive component of leaf extracts of L . erythrorhizon root (Gwon et al, 2012; Pietrosiuk et al, 2006; Zhao, Wu, Wu, Zhao, & Chen, 2016), exhibits various pharmacological activities including induction of autophagy, anti‐oxidative, anti‐inflammatory, anti‐proliferative, anti‐fertility, and anticancer effects (He, Li, Su, Huang, & Zhu, 2016; Pietrosiuk et al, 2006; Skrzypczak et al, 2015; Wu et al, 2011; Zeng, Zhu, & Su, 2018). Several studies have demonstrated that the compound inhibits growth of a variety of cancers, including colorectal, breast, liver, medullary thyroid carcinoma, pancreas, melanoma, and gastric cancers (Cho & Choi, 2015; Hasenoehrl et al, 2017; Kim, Lee, Park, & Choi, 2016; Kretschmer et al, 2012; Park et al, 2017; Vukic et al, 2017; Zeng, Liu, & Zhou, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies have reported that abnormal autophagy may play an important role in the pathogenesis of NAFLD (16). Acetylshikonin improved NAFLD by increasing hepatocyte autophagy through mTOR pathway (17). Likewise, Veskovic et al indicated that the beneficial effect of betaine in methionine-choline deficient diet (MCD)-induced NAFLD is related to reduced oxidative stress, inflammation and apoptosis, and increased autophagy (18).…”
Section: Introductionmentioning
confidence: 99%
“…FLCN seemed to be involved in regulating autophagy in a severe liver disease setting and it is possibly the primary mechanism of action by which loss of Flcn reduces liver fibrosis. Several compounds known to activate autophagy pathways such as acetylshikonin and resveratrol also reduced MCD-induced fibrosis and inflammation 37 , 38 . Acetylshikonin contributed to the removal of cellular lipid droplets through lipophagy in a process dependent on the AMPK/mTOR pathways 37 .…”
Section: Discussionmentioning
confidence: 96%