Autophagy may protect the brain against prolonged consequences of headache attacks: A narrative/hypothesis review

Fila, Michal; Pawlowska, Elzbieta; Szczepanska, Joanna; Blasiak, Janusz

doi:10.1111/head.14625

Cited by 4 publications

(3 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several reports suggest a link between autophagy and ferroptosis underlined by the involvement of autophagy in the regulation of iron-dependent lipid peroxidation and RONS production during ferroptosis ( Lee et al, 2023 ). We have recently argued that an interplay between degradative autophagy in neurons and secretory autophagy in the glia might protect the brain against prolonged consequences of migraine attacks ( Fila et al, 2023b ). Therefore, ferroptosis may be coupled with autophagy in migraine.…”

Section: Ferroptosis Ferritinophagy and Their Potential In Migrainementioning

confidence: 99%

“…Autophagy raises an emerging interest in the study of the pathogenesis of various diseases, but there is a lack of experimental or clinical studies showing the involvement of autophagy in migraine pathogenesis. However, increased iron deposits in certain areas of the brain may be a source of many substrates for both degradative and secretory autophagy ( Fila et al, 2023b ). Iron deposited in the brain may stimulate ferritinophagy, which interplays with ferroptosis and may disturb nociceptive signaling important in migraine.…”

Section: Conclusion Perspectives and Outstanding Questionsmentioning

confidence: 99%

See 1 more Smart Citation

Potential of ferroptosis and ferritinophagy in migraine pathogenesis

Fila,

Przyslo,

Derwich

et al. 2024

Front. Mol. Neurosci.

Self Cite

View full text Add to dashboard Cite

ObjectiveTo assess the potential of ferroptosis and ferritinophagy in migraine pathogenesis.BackgroundFerroptosis and ferritinophagy are related to increased cellular iron concentration and have been associated with the pathogenesis of several neurological disorders, but their potential in migraine pathogenesis has not been explored. Increased iron deposits in some deep brain areas, mainly periaqueductal gray (PAG), are reported in migraine and they have been associated with the disease severity and chronification as well as poor response to antimigraine drugs.ResultsIron deposits may interfere with antinociceptive signaling in the neuronal network in the brain areas affected by migraine, but their mechanistic role is unclear. Independently of the location, increased iron concentration may be related to ferroptosis and ferritinophagy in the cell. Therefore, both phenomena may be related to increased iron deposits in migraine. It is unclear whether these deposits are the reason, consequence, or just a correlate of migraine. Still, due to migraine-related elevated levels of iron, which is a prerequisite of ferroptosis and ferritinophagy, the potential of both phenomena in migraine should be explored. If the iron deposits matter in migraine pathogenesis, they should be mechanically linked with the clinical picture of the disease. As iron is an exogenous essential trace element, it is provided to the human body solely with diet or supplements. Therefore, exploring the role of iron in migraine pathogenesis may help to determine the potential role of iron-rich/poor dietary products as migraine triggers or relievers.ConclusionFerroptosis and ferritinophagy may be related to migraine pathogenesis through iron deposits in the deep areas of the brain.

show abstract

Section: Ferroptosis Ferritinophagy and Their Potential In Migrainementioning

confidence: 99%

Section: Conclusion Perspectives and Outstanding Questionsmentioning

confidence: 99%

Potential of ferroptosis and ferritinophagy in migraine pathogenesis

Fila,

Przyslo,

Derwich

et al. 2024

Front. Mol. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the other hand, several studies with long-lived organisms showed that delayed aging was associated with increased autophagy [91][92][93][94]. Recently, we suggested that an interplay between secretory autophagy in microglia and degradative autophagy in neurons may play a role in migraine pathogenesis with the involvement of brain-derived neurotrophic factor (BDNF) and the interaction of ATP with the purinergic receptor P2X7 (P2X7R) [95]. It was observed that a ketogenic diet upregulated hepatic autophagy in mice [96].…”

Section: The Ketogenic Diet and Ketone Bodies In Agingmentioning

confidence: 99%

The Ketogenic Diet in the Prevention of Migraines in the Elderly

Fila,

Chojnacki,

Pawlowska

et al. 2023

Nutrients

Self Cite

View full text Add to dashboard Cite

Migraines display atypical age dependence, as the peak of their prevalence occurs between the ages of 20–40 years. With age, headache attacks occur less frequently and are characterized by a lower amplitude. However, both diagnosis and therapy of migraines in the elderly are challenging due to multiple comorbidities and polypharmacy. Dietary components and eating habits are migraine triggers; therefore, nutrition is a main target in migraine prevention. Several kinds of diets were proposed to prevent migraines, but none are commonly accepted due to inconsistent results obtained in different studies. The ketogenic diet is featured by very low-carbohydrate and high-fat contents. It may replace glucose with ketone bodies as the primary source of energy production. The ketogenic diet and the actions of ketone bodies are considered beneficial in several aspects of health, including migraine prevention, but studies on the ketogenic diet in migraines are not standardized and poorly evidenced. Apart from papers claiming beneficial effects of the ketogenic diet in migraines, several studies have reported that increased levels of ketone bodies may be associated with all-cause and incident heart failure mortality in older adults and are supported by research on mice showing that the ketogenic diets and diet supplementation with a human ketone body precursor may cause life span shortening. Therefore, despite reports showing a beneficial effect of the ketogenic diet in migraines, such a diet requires further studies, including clinical trials, to verify whether it should be recommended in older adults with migraines.

show abstract

Potential of focal cortical dysplasia in migraine pathogenesis

Fila,

Przyslo,

Derwich

et al. 2024

Cerebral Cortex

View full text Add to dashboard Cite

Focal cortical dysplasias are abnormalities of the cerebral cortex associated with an elevated risk of neurological disturbances. Cortical spreading depolarization/depression is a correlate of migraine aura/headache and a trigger of migraine pain mechanisms. However, cortical spreading depolarization/depression is associated with cortical structural changes, which can be classified as transient focal cortical dysplasias. Migraine is reported to be associated with changes in various brain structures, including malformations and lesions in the cortex. Such malformations may be related to focal cortical dysplasias, which may play a role in migraine pathogenesis. Results obtained so far suggest that focal cortical dysplasias may belong to the causes and consequences of migraine. Certain focal cortical dysplasias may lower the threshold of cortical excitability and facilitate the action of migraine triggers. Migraine prevalence in epileptic patients is higher than in the general population, and focal cortical dysplasias are an established element of epilepsy pathogenesis. In this narrative/hypothesis review, we present mainly information on cortical structural changes in migraine, but studies on structural alterations in deep white matter and other brain regions are also presented. We develop the hypothesis that focal cortical dysplasias may be causally associated with migraine and link pathogeneses of migraine and epilepsy.

show abstract

Autophagy may protect the brain against prolonged consequences of headache attacks: A narrative/hypothesis review

Cited by 4 publications

References 128 publications

Potential of ferroptosis and ferritinophagy in migraine pathogenesis

Potential of ferroptosis and ferritinophagy in migraine pathogenesis

The Ketogenic Diet in the Prevention of Migraines in the Elderly

Potential of focal cortical dysplasia in migraine pathogenesis

Contact Info

Product

Resources

About