Autophagy: Regulation and role in disease

Meijer, Alfred J.; Codogno, Patrice

doi:10.1080/10408360903044068

Cited by 185 publications

(185 citation statements)

References 398 publications

(523 reference statements)

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“…Several recent reviews have been dedicated to the regulation of autophagy by signaling pathways [46,97,98]. In this section we would like to focus on signaling pathways with identified targets in the molecular machinery of autophagosome formation.…”

Section: Cytoplasmic and Nuclear Regulation Of Mammalian Autophagymentioning

confidence: 99%

“…Signaling segments acting upstream of mTORC1 and mTORC2 that regulate autophagy have been discussed in recent reviews that the reader can consult for more information [46,98]. mTORC1 substrates and the regulation of autophagy As discussed above, ULK1, Atg13 and FIP200 form a stable complex that signals to the autophagic machinery downstream of mTORC1.…”

Section: Cytoplasmic Regulation Mtorc1 and Mtorc2mentioning

confidence: 99%

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Overview of macroautophagy regulation in mammalian cells

et al. 2010

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Macroautophagy is a multistep, vacuolar, degradation pathway terminating in the lysosomal compartment, and it is of fundamental importance in tissue homeostasis. In this review, we consider macroautophagy in the light of recent advances in our understanding of the formation of autophagosomes, which are double-membrane-bound vacuoles that sequester cytoplasmic cargos and deliver them to lysosomes. In most cases, this final step is preceded by a maturation step during which autophagosomes interact with the endocytic pathway. The discovery of AuTophaGyrelated genes has greatly increased our knowledge about the mechanism responsible for autophagosome formation, and there has also been progress in the understanding of molecular aspects of autophagosome maturation. Finally, the regulation of autophagy is now better understood because of the discovery that the activity of Atg complexes is targeted by protein kinases, and owing to the importance of nuclear regulation via transcription factors in regulating the expression of autophagy genes.

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Section: Cytoplasmic and Nuclear Regulation Of Mammalian Autophagymentioning

confidence: 99%

Section: Cytoplasmic Regulation Mtorc1 and Mtorc2mentioning

confidence: 99%

Overview of macroautophagy regulation in mammalian cells

et al. 2010

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“…Autophagy is closely involved in the etiology of many important human diseases, including cancer, neurodegenerative diseases and metabolic disorders (Meijer and Codogno 2009).…”

Section: Autophagymentioning

confidence: 99%

Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer

Chaabane

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El-Gazzah

et al. 2012

Arch. Immunol. Ther. Exp.

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“…Increasing studies have shown that autophagy is involved in many human diseases (such as neurodegenerative diseases and cancer) and plays roles in their pathogenesis [2,3] . Uncovering the role of autophagy in these diseases is essential because it may present a novel therapeutic target.…”

Section: Introductionmentioning

confidence: 99%

Application and interpretation of current autophagy inhibitors and activators

et al. 2013

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Autophagy is the major intracellular degradation system, by which cytoplasmic materials are delivered to and degraded in the lysosome. As a quality control mechanism for cytoplasmic proteins and organelles, autophagy plays important roles in a variety of human diseases, including neurodegenerative diseases, cancer, cardiovascular disease, diabetes and infectious and inflammatory diseases. The discovery of ATG genes and the dissection of the signaling pathways involved in regulating autophagy have greatly enriched our knowledge on the occurrence and development of this lysosomal degradation pathway. In addition to its role in degradation, autophagy may also promote a type of programmed cell death that is different from apoptosis, termed type II programmed cell death. Owing to the dual roles of autophagy in cell death and the specificity of diseases, the exact mechanisms of autophagy in various diseases require more investigation. The application of autophagy inhibitors and activators will help us understand the regulation of autophagy in human diseases, and provide insight into the use of autophagy-targeted drugs. In this review, we summarize the latest research on autophagy inhibitors and activators and discuss the possibility of their application in human disease therapy.

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Autophagy: Regulation and role in disease

Cited by 185 publications

References 398 publications

Overview of macroautophagy regulation in mammalian cells

Overview of macroautophagy regulation in mammalian cells

Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer

Application and interpretation of current autophagy inhibitors and activators

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