2024
DOI: 10.1002/jgm.3685
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Autophagy‐related CMTM6 promotes glioblastoma progression by activating Wnt/β‐catenin pathway and acts as an onco‐immunological biomarker

Lirui Dai,
Jingjia Xiao,
Xiang Li
et al.

Abstract: BackgroundGlioblastoma multiforme (GBM) is identified as one of the most prevalent and malignant brain tumors, characterized by poor treatment outcomes and a limited prognosis. CMTM6, a membrane protein, has been found to upregulate the expression of programmed cell death 1 ligand 1 protein (PD‐L1) and acts as an immune checkpoint inhibitor by inhibiting the programmed death 1 protein/PD‐L1 signaling pathway. Recent research has demonstrated a high expression of CMTM6 in GBM, suggesting its potential role in i… Show more

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