Autophagy-Related Proteins Are Differentially Expressed in Adrenal Cortical Tumor/Pheochromocytoma and Associated with Patient Prognosis

Kim, Hye Min; Koo, Ja Seung

doi:10.3390/ijms221910490

Cited by 4 publications

(4 citation statements)

References 39 publications

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“…What’ s more, Hye Min Kim et al. Showed that autophagy-related proteins are differentially expressed in pheochromocytoma patients and correlate with patient prognosis ( 31 ). Additionally, the role of neuroinflammation and neurotoxicity in the pathogenesis of pheochromocytoma has been gradually increasing in recent years ( 32 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

“…(PC12 cell) function by activating the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/AKT) pathway, which was a key pathophysiology of pheochromocytoma (30). What' s more, Hye Min Kim et al Showed that autophagy-related proteins are differentially expressed in pheochromocytoma patients and correlate with patient prognosis (31). Additionally, the role of neuroinflammation and neurotoxicity in the pathogenesis of pheochromocytoma has been gradually increasing in recent years (32,33).…”

Section: B Amentioning

confidence: 99%

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Global trends and current status in pheochromocytoma: a bibliometric analysis of publications in the last 20 years

Huang,

Liu,

Teng

et al. 2023

Front. Endocrinol.

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ObjectivePheochromocytoma is a rare catecholamine-producing neuroendocrine tumour originating from the chromaffin cells of the adrenal medulla or extra-adrenal paraganglia. However, there are few bibliometric studies on Pheochromocytoma. Therefore, this study was employed to summarize the global trends and current status in pheochromocytoma by bibliometric analysis.Materials and methodsThe Web of Science (WOS) core collection database was searched for publications relating to pheochromocytoma from 2001 to 2021. Bibliometric analysis was used to examine the data, and Microsoft Excel was utilized to create bar graphs. In addition, VOSviewer was used to carry out co-authorship analysis, co-citation analysis and co-occurrence analysis. CiteSpace was used to analyze the keywords citation bursts.ResultsA total of 8,653 publications published in 1,806 journals by 38,590 authors in 6,117 organizations from 100 countries/regions were included in our study. Among them, USA was the leading countries in terms of total publications and sum of time cited, whereas Eunice Kennedy Shriver Natl Inst Child Hlth & Hum was the leading institutions. The main publications for pheochromocytoma-related articles were Journal of clinical endocrinology &metabolism. Pacak karel and Eisenhofer Graeme were the main contributing authors. The studies on pheochromocytoma could be grouped into five clusters: Treatment, Mechanism, Etiology, Radiology and Hormones study. Moreover, the radiology study, etiology study and some specific keywords such germlines mutation, mesenchymal stem-cells, autophagy, neuroinflammation, neurotoxicity, and hemodynamic instability, may become the hot spots of future.ConclusionAlthough the number of articles on pheochromocytoma has fluctuated slightly over the past 20 years, there has been an overall upward trend. In general, precision medicine research on pheochromocytoma, especially metastatic pheochromocytoma, in terms of diagnosis, treatment, and etiology will be a hot research topic in the future. This study helps to understand the research perspectives, hot spots and trends of pheochromocytoma and provide new insight and a basis for future pheochromocytoma research quickly.

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Section: Discussionmentioning

confidence: 99%

Section: B Amentioning

confidence: 99%

Global trends and current status in pheochromocytoma: a bibliometric analysis of publications in the last 20 years

Huang,

Liu,

Teng

et al. 2023

Front. Endocrinol.

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“…The number of studies that evaluated the levels of important modulators of autophagy in tumoral adrenal samples is low. A recent study analyzed the expression of autophagy players in adrenal tumors from patients, by immunohistochemistry, and integrated these results with the patients' clinicopathologic parameters (30). Tissue microarray was performed in 115 cases of adrenocortical adenoma (ACA), 17 ACC cases and 189 PCC.…”

Section: Expression Of Autophagic Key Players In Adrenal Tumor Tissuesmentioning

confidence: 99%

Modulation of Autophagy in Adrenal Tumors

Sousa

Pereira²,

Pignatelli³

2022

Front. Endocrinol.

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Adrenal masses are one of the most common tumors in humans. The majority are benign and non-functioning and therefore do not require immediate treatment. In contrast, the rare adrenal malignant tumors are often highly aggressive and with poor prognosis. Besides usually being detected in advanced stages, often already with metastases, one of the reasons of the unfavorable outcome of the patients with adrenal cancer is the absence of effective treatments. Autophagy is one of the intracellular pathways targeted by several classes of chemotherapeutics. Mitotane, the most commonly used drug for the treatment of adrenocortical carcinoma, was recently shown to also modulate autophagy. Autophagy is a continuous programmed cellular process which culminates with the degradation of cellular organelles and proteins. However, being a dynamic mechanism, understanding the autophagic flux can be highly complex. The role of autophagy in cancer has been described paradoxically: initially described as a tumor pro-survival mechanism, different studies have been showing that it may result in other outcomes, namely in tumor cell death. In adrenal tumors, this dual role of autophagy has also been addressed in recent years. Studies reported both induction and inhibition of autophagy as a treatment strategy of adrenal malignancies. Importantly, most of these studies were performed using cell lines. Consequently clinical studies are still required. In this review, we describe what is known about the role of autophagy modulation in treatment of adrenal tumors. We will also highlight the aspects that need further evaluation to understand the paradoxical role of autophagy in adrenal tumors.

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“…In the light of these observations, it has been hypothesized that Immunoexpression of p62/SQSTM1/Sequestosome-1 in human primary and recurrent IDH1/2 wild-type glioblastoma: A pilot study p62 may promote the progression of cancer by repressing the apoptotic resistance and generating reactive oxygen species (ROS), thus, enhancing cell proliferation, tumorigenesis, and metastasis (20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

Immunoexpression of p62/SQSTM1/Sequestosome‑1 in human primary and recurrent IDH1/2 wild‑type glioblastoma: A pilot study

et al. 2022

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Asbstract. p62/SQSTM1/Sequestosome-1 is an autophagic protein that serves a crucial role in cellular metabolism, proliferation and malignant growth. Notably, autophagy may influence the development and resistance to therapy of numerous types of human cancer. In the present pilot study, the immunohistochemical pattern of p62 was analyzed in a cohort of patients with isocitrate dehydrogenase (IDH)1/2 wild-type glioblastoma (GBM), in primary and recurrent samples, in order to verify the concordance or discordance between the primary and recurrent tumors. In addition, the association between p62, and patient outcome and O 6 -methylguanine-DNA methyltransferase (MGMT) status was assessed. The results revealed p62 immunoexpression in the nucleus and cytoplasm of neoplastic elements in 45% of primary and 55% of recurrent cases of GBM. A discordant p62 immunoreactivity was detected in 35% of cases, with a variation either with positive or negative conversion of p62 status. Statistically, p62 expression and MGMT status exhibited a significant prognostic value by univariate analysis, whereas only MGMT promoter methylation status emerged as an independent prognostic factor by multivariate analysis. Finally, the most favorable prognosis was documented when the same GBM case was positively concordant for both p62 expression and MGMT methylated status. Since little data are available regarding the association between p62 expression and MGMT in GBM, further investigations may be required to determine if new targeted therapies may be addressed against autophagy-related proteins, such as p62.

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Autophagy-Related Proteins Are Differentially Expressed in Adrenal Cortical Tumor/Pheochromocytoma and Associated with Patient Prognosis

Cited by 4 publications

References 39 publications

Global trends and current status in pheochromocytoma: a bibliometric analysis of publications in the last 20 years

Global trends and current status in pheochromocytoma: a bibliometric analysis of publications in the last 20 years

Modulation of Autophagy in Adrenal Tumors

Immunoexpression of p62/SQSTM1/Sequestosome‑1 in human primary and recurrent IDH1/2 wild‑type glioblastoma: A pilot study

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