Autoproliferative and self-reactive T-cell lines from patients with HTLV-I-associated myelopathy.

Usuku, Koichiro; Nishizawa, Manabu; Eiraku, Nobutaka; Osame, Mitsuhiro; Tabira, Takeshi

doi:10.1620/tjem.162.243

Cited by 5 publications

(1 citation statement)

References 31 publications

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“…Die Oligoklonalität (Wattel et al (1995)) und der erhöhte Anteil HTLV-1 infizierter T-Lymphozyten bei HAM/TSP Patienten (Yoshida et al (1989), Kubota et al (1993), Furukawa et al (1992 (Gessain und Gout (1992), Wucherpfennig et al (1992), Shinzato et al (1993), Nowak und Bangham (1996), Nagai et al (1998)). Die Eigenschaften der T-Lymphozyten Klone (Usuku et al (1990), Wattel et al (1995)), die Regulation der retroviralen und zellulären Genexpression durch HTLV-1 tax (Brady (1996)) sowie immungenetische Faktoren (Usuku et al (1988), Sonoda et al (1996), Jeffery et al (1999)) könnten zusätzlich für die Krankheitsentstehung bedeutsam sein.…”

Section: Epidemiologie Der Htlv Infektionenunclassified

Die Spezifität der systemischen und intrathekalen Immunantwort bei der Infektion mit dem humanen T-lymphotropen Virus 1 (HTLV-1)

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Section: Epidemiologie Der Htlv Infektionenunclassified

Die Spezifität der systemischen und intrathekalen Immunantwort bei der Infektion mit dem humanen T-lymphotropen Virus 1 (HTLV-1)

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Suppression of lymphocyte spontaneous proliferative response by proteolipid protein peptide in patients with HAM/TSP

et al. 1994

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To understand the immune mechanism suggested in HTLV-I-associated myelopathy (HAM/TSP), we investigated T cell response to proteolipid protein (PLP). Because of high autologous proliferative response (APR) of peripheral blood mononuclear cells (PBMC) in culture, the lymphocyte proliferation assay was not useful in this disease. Unexpectedly, however, APR was profoundly (70-98%) suppressed in 6 of 9 cases when PLP peptide 105-124 was added in the culture. PLP peptide 85-104 or 145-159 also suppressed APR in a few cases. Time course study showed that the peptide-mediated suppression became apparent after day 4 in culture. The results can be interpreted as that suppressor cells recognizing the PLP peptides were present in the PBMC of HAM/TSP patients and suppressed the APR as the consequence of antigen specific response. This may indicate that a T cell response to certain PLP determinants is involved in the pathomechanism of HAM/TSP at least in part. Molecular mimicry between PLP and HTLV-I may account for the T cell sensitization to PLP in HAM/TSP.

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Cytotoxic and suppressor activities in patients with HTLV-I-associated myelopathy

Usuku

Nishizawa

Osame

et al. 1991

Journal of Neuroimmunology

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Autoproliferative and self-reactive T-cell lines from patients with HTLV-I-associated myelopathy.

Cited by 5 publications

References 31 publications

Die Spezifität der systemischen und intrathekalen Immunantwort bei der Infektion mit dem humanen T-lymphotropen Virus 1 (HTLV-1)

Die Spezifität der systemischen und intrathekalen Immunantwort bei der Infektion mit dem humanen T-lymphotropen Virus 1 (HTLV-1)

Suppression of lymphocyte spontaneous proliferative response by proteolipid protein peptide in patients with HAM/TSP

Cytotoxic and suppressor activities in patients with HTLV-I-associated myelopathy

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