Autopsy report and review of the 2016 WHO classification of congenital supratentorial embryonal tumors, not otherwise specified

Cambruzzi, Eduardo; Pêgas, Karla Laís; Nascimento, Gabriella Bezerra Cortês; Silva, José Nathan Andrade Muller da; Zandoná, Natália Brandelli; Medeiros, Mateus Scarabelot

doi:10.1016/j.inat.2020.100913

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…Overall, neoplastic cells are positive for synaptophysin, GFAP, INI1, CD99, and vimentin and may also express NFP, EMA, p53, and CKM. (2) The treatment consists of complete surgical excision; chemotherapy and radiation are necessary adjuncts. Generally, they have a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Occipital and Parietal Central Nervous System Embryonal Tumor NOS in an Adult Patient : A Case Report

Ghammem

Mokrani

Mansouri

et al. 2023

Preprint

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Introduction:CNS embryonal tumors are highly malignant undifferentiated or poorly differentiated tumors of neuroepithelial origin, they take origin from embryonic cells that remain in the brain after birth, These tumors tend to spread through the cerebrospinal fluid (CSF) to other parts of the brain and spinal cord.Central nervous system embryonal tumor, not otherwise specified (NOS) was previously called primitive neuroectodermal tumors (PNET), these are rare tumors that form in the brain and spinal cord. (1)We describe CNS (NOS) that arose in the occipital lobe of a 27 year old patient.

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Section: Discussionmentioning

confidence: 99%

Occipital and Parietal Central Nervous System Embryonal Tumor NOS in an Adult Patient : A Case Report

Ghammem

Mokrani

Mansouri

et al. 2023

Preprint

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“…Misclassification of these tumors as other embryonal tumors can happen due to their complex and varied histological patterns as well as the rarity of the tumor and polyphenotypic immunoprofiles (4,11) (12,13). The present study aims to evaluate the INI1 nuclear expression in different types of high-grade brain tumors to rule out any possibility of ATRT misdiagnosis.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of INI1 Protein Expression Through IHC Study in Pediatric High-Grade Brain Tumors in South of Iran in 2008-2021

Mohebbi,

Shokripour,

Mokhtari

2023

Iran J Pathol

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Scan to discover online Background & Objective: Brain tumors are the most frequent solid tumors in children. High-grade tumors are more challenging in diagnosis. Atypical teratoid rhabdoid tumor (ATRT) may be mistaken for other high-grade brain tumors. Molecular genetic analysis of ATRT has shown deletion and mutation in the hSNF5/INI1 gene in most of the cases. The INI1 protein expression can be helpful for the accurate diagnosis. Methods: In this study, immunohistochemical staining (IHC) using INI1 antibody was performed to determine the possibility of ATRT misdiagnosis. Totally, 147 tumors including 6 ATRTs, 81 medulloblastomas, and 60 other CNS tumors were examined in children between 0 and 17 years old.Results: No nuclear staining was found in the six ATRT cases, while most of other CNS tumors demonstrated nuclear staining. Five cases were previously diagnosed with medulloblastoma, primitive neuroectodermal tumor (PNET), and anaplastic oligodendroglioma, while the diagnoses were changed to ATRT based on the reevaluation of the H&E slides and INI1 study. Additionally, two cases were recurrent tumors whose features were consistent with those of ATRT. The INI1 immunostaining was negative in these cases. Conclusion:INI1 was very helpful in distinguishing ATRT from its mimickers in challenging cases. All known ATRT cases in this study were immunonegative for INI1. Thus, INI1 is recommended to be used in the initial IHC panel for the high-grade brain tumors, especially in children under the age of three years, so that they can benefit from intensified therapeutic regimens.

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“…7,11,13 Within the relevant literature, 10 articles concerning congenital supratentorial embryonal tumors can be found on a global level (Table S1). 4,5,8,9,[13][14][15][16][17][18][19] A limitation of these case studies is that they do not yield overall survival information for the described cases (i.e., in a semester's time, after a year, etc.). A full presentation and discussion is included in…”

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confidence: 99%

Congenital embryonal tumor of the central nervous system with a rapidly fatal outcome in the neonatal intensive care unit

Nikolaidis

Karakasi

Boziki

et al. 2022

Pediatric Blood & Cancer

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Autopsy report and review of the 2016 WHO classification of congenital supratentorial embryonal tumors, not otherwise specified

Cited by 3 publications

References 27 publications

Occipital and Parietal Central Nervous System Embryonal Tumor NOS in an Adult Patient : A Case Report

Occipital and Parietal Central Nervous System Embryonal Tumor NOS in an Adult Patient : A Case Report

Evaluation of INI1 Protein Expression Through IHC Study in Pediatric High-Grade Brain Tumors in South of Iran in 2008-2021

Congenital embryonal tumor of the central nervous system with a rapidly fatal outcome in the neonatal intensive care unit

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