Autoradiographic analysis of D1 and D2 dopaminergic receptors in rat brain after paradoxical sleep deprivation

Nunes, Gustavo; Tufik, Sérgio; Nóbrega, José N.

doi:10.1016/0361-9230(94)90018-3

Cited by 122 publications

(43 citation statements)

References 15 publications

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“…An alternative explanation given by Tufik and colleagues involves increased dopaminergic activity at the presynaptic level. Using an autoradiographic technique, Nunes Jr. et al (19) showed that REM sleep deprivation resulted in an augmented population of D2 receptors in rats. The association of REM sleep deprivation with an injection of haloperidol 24 h before apomorphine administration induced an even higher level of aggressive behavior than that of rats submitted only to sleep deprivation.…”

Section: The Effects Of Haloperidol and Sleep Deprivation On Sawtoothmentioning

confidence: 99%

Sawtooth waves during REM sleep after administration of haloperidol combined with total sleep deprivation in healthy young subjects

Pinto

Peres

Russo

et al. 2002

Braz J Med Biol Res

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We sought to examine the possible participation of dopaminergic receptors in the phasic events that occur during rapid eye movement (REM) sleep, known as sawtooth waves (STW). These phasic phenomena of REM sleep exhibit a unique morphology and, although they represent a characteristic feature of REM sleep, little is known about the mechanisms which generate them and which are apparently different from rapid eye movements. STW behavior was studied in 10 male volunteers aged 20 to 35 years, who were submitted to polysomnographic monitoring (PSG). On the adaptation night they were submitted to the first PSG and on the second night, to the basal PSG. On the third night the volunteers received placebo or haloperidol and spent the whole night awake. On the fourth night they were submitted to the third PSG. After a 15-day rest period, the volunteers returned to the sleep laboratory and, according to a double-blind crossover randomized design, received haloperidol or placebo and spent the whole night awake, after which they were submitted to the fourth PSG. The volunteers who were given haloperidol combined with sleep deprivation exhibited an elevation of the duration and density of the STW, without significant alterations of the other REM sleep phasic phenomena such as rapid eye movement. These findings suggest that sawtooth waves must have their own generating mechanisms and that the dopaminergic receptors must exert a modulating role since REM sleep deprivation, as well as administration of neuroleptics, produces supersensitivity of dopaminergic receptors. Correspondence

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Section: The Effects Of Haloperidol and Sleep Deprivation On Sawtoothmentioning

confidence: 99%

Sawtooth waves during REM sleep after administration of haloperidol combined with total sleep deprivation in healthy young subjects

Pinto

Peres

Russo

et al. 2002

Braz J Med Biol Res

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“…Patients with PD who have extensive loss of dopaminergic cells within the SNpc, and less so within the ventral tegmental area, often have increased sleepiness, which is made worse by the presence of dopaminergic D 2 receptor agonists [10], [11]. Such involvement of DA has been described subsequent to sleep deprivation as being directly involved in the generation of dopaminergic D 2 receptor supersensitivity [12], [13], [14]. Moreover, recent findings demonstrate that partial DA depletion causes disturbances of REM sleep without affecting motor functions [15].…”

Section: Introductionmentioning

confidence: 99%

The Role of the Substantia Nigra Pars Compacta in Regulating Sleep Patterns in Rats

et al. 2007

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BackgroundAs of late, dopaminergic neurotransmission has been recognized to be involved in the generation of sleep disturbances. Increasing evidence shows that sleep disturbances in Parkinson's disease (PD) patients are mostly related to the disease itself, rather than being a secondary phenomenon. Evidence contained in the literature lends support to the hypothesis that the dopaminergic nigrostriatal pathway is closely involved in the regulation of sleep patterns.Methodology/Principal FindingsTo test this hypothesis we examined the electrophysiological activity along the sleep-wake cycle of rats submitted to a surgically induced lesion of the SNpc by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We demonstrated that a 50% lesion of the substantia nigra pars compacta (SNpc) suffices to produce disruptions of several parameters in the sleep-wake pattern of rats. A robust and constant decrease in the latency to the onset of slow wave sleep (SWS) was detected throughout the five days of recording in both light [F(22.16) = 72.46, p<0.0001] and dark [F(22.16) = 75.0, p<0.0001] periods. Also found was a pronounced increase in the percentage of sleep efficiency during the first four days of recording [F(21.15) = 21.48, p<0.0001], in comparison to the sham group. Additionally, the reduction in the SNpc dopaminergic neurons provoked an ablation in the percentage of rapid eye movement sleep (REM) during three days of the sleep-wake recording period with a strong correlation (r = 0.91; p<0.0001) between the number of dopaminergic neurons lost and the percentage decrease of REM sleep on the first day of recording. On day 4, the percentage of REM sleep during the light and dark periods was increased, [F(22.16) = 2.46, p<0.0007], a phenomenon consistent with REM rebound.Conclusions/SignificanceWe propose that dopaminergic neurons present in the SNpc possess a fundamental function in the regulation of sleep processes, particularly in promoting REM sleep.

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“…Another REM sleep deprivation study showed that after 96 h of REM sleep deprivation, DOPAC (a dopamine metabolite) levels were elevated in the striatum and there were no changes in D2 receptor binding . Others have found that D2 receptor levels are elevated in the nucleus accumbens and caudate-putamen following 96 h of sleep deprivation in rats, while D1 receptor levels are unchanged (Nunes Jr et al, 1994). Sleep deprivation in rats also results in increased aggression to apomorphine (non-selective dopamine receptor agonist), which is blocked by pretreatment with D2 antagonists (Tufik et al, 1978;Tufik, 1981), suggesting that D2 receptor supersensitivity evolves with sleep deprivation.…”

Section: Sleep Deprivation and Dopamine In Animalsmentioning

confidence: 99%

Schizophrenia: the role of sleep and circadian rhythms in regulating dopamine and psychosis

Yates

2016

Reviews in the Neurosciences

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AbstractSchizophrenia has long been associated with abnormalities in circadian rhythms and sleep. Up until now, there have been no thorough reviews of the potential mechanisms behind the myriad of circadian and sleep abnormalities observed in schizophrenia and psychosis. We present evidence of sleep playing an important role in psychosis predominantly mediated by dopaminergic pathways. A synthesis of both human and animal experimental work suggests that the interplay between sleep and dopamine is important in the generation and maintenance of psychosis. In particular, both animal and human data point to sleep disruption increasing dopamine release and sensitivity. Furthermore, elevated dopamine levels disrupt sleep and circadian rhythms. The synthesis of knowledge suggests that circadian rhythms, dopamine dysregulation, and psychosis are intricately linked. This suggests that treatment of circadian disturbance may be a useful target in improving the lives and symptoms of patients with schizophrenia.

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Autoradiographic analysis of D1 and D2 dopaminergic receptors in rat brain after paradoxical sleep deprivation

Cited by 122 publications

References 15 publications

Sawtooth waves during REM sleep after administration of haloperidol combined with total sleep deprivation in healthy young subjects

Sawtooth waves during REM sleep after administration of haloperidol combined with total sleep deprivation in healthy young subjects

The Role of the Substantia Nigra Pars Compacta in Regulating Sleep Patterns in Rats

Schizophrenia: the role of sleep and circadian rhythms in regulating dopamine and psychosis

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