Autoradiographic localization of dopamine D1 and D2 receptors in the brain of several mammalian species

Camps, Montserrat; Kelly, Peter H.; Palacios, J.M.

doi:10.1007/bf01257077

Cited by 198 publications

(98 citation statements)

References 70 publications

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“…However, this is not necessarily true. DA D 2 and D 3 receptors have a quite different distribution in the brain (Bouthenet et al, 1991;Levant, 1998;Camps et al, 1990;Richfield et al, 1987). So drugs acting on D 3 or D 2 receptors might both reduce cued reinstatement but through different neural sites of action.…”

Section: Discussionmentioning

confidence: 99%

Cocaine-Seeking Behavior in Response to Drug-Associated Stimuli in Rats: Involvement of D3 and D2 Dopamine Receptors

Cervo

Carnovali

Stark

et al. 2003

Neuropsychopharmacol

108

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Previous studies employed a second-order schedule paradigm maintained by cocaine reinforcement to show that BP897, a dopamine D 3 partial agonist, selectively modulated drug-seeking behavior. We investigated its effect on drug-seeking behavior induced by presentation of stimuli associated with and predictive of cocaine availability after a period of extinction and in the absence of any further cocaine. Male rats were trained to associate discriminative stimuli (S D ) with the availability of intravenous (i.v.) 0.25 mg/0.1 ml/infusion cocaine (S D+ ) or no-reward (S DÀ ) saline solution. Each infusion of cocaine or saline was followed by a response-cue signaling 20-s time-out (TO). After meeting the self-administration training criterion rats were placed on extinction conditions during which i.v. solutions and S D s were withheld. Every other 3 days on which rats met the extinction criterion, reinstatement tests were conducted, presenting the S D+ or S DÀ noncontingently together with a contingent presentation of cocaine-or saline-cues signaling 20-s TO. Regardless of the order of presentation or the nature of the stimuli (auditory or visual), cocaine-associated but not saline-associated stimuli reinstated responding on the previously active lever. Presentation of cocaine-associated stimuli induced lasting drug-seeking behavior for at least eight test sessions. BP897 (1.0 mg/kg i.p.) significantly attenuated this behavior. Since it has been reported that BP897 can interact with a panel of different receptors with high affinity, we evaluated the effects of 7-OH-DPAT, an agonist to D 3 receptors, raclopride, a preferential antagonist to D 2 receptors, and WAY 100,635, an antagonist at 5-HT 1A receptors, on drug-seeking behavior. 7-OH-DPAT (0.1-3.0 mg/kg i.p.) had biphasic effects on reinstatement induced by the cocaine-associated cues, low dosages reducing and high dosages increasing the impact of cocaine-associated stimuli on rats' behavior. Raclopride (0.1, 0.3 mg/kg s.c.) completely prevented drug-seeking behavior induced by the reintroduction of cocaine-associated stimuli. WAY 100,635 (0.1-1.0 mg/kg s.c.) had no effect on this behavior. These results, while confirming that the partial agonist at the D 3 receptors, BP897, might be a useful medication, also suggest a role of D 2 receptors in cueinduced cocaine-seeking behavior.

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Section: Discussionmentioning

confidence: 99%

Cocaine-Seeking Behavior in Response to Drug-Associated Stimuli in Rats: Involvement of D3 and D2 Dopamine Receptors

Cervo

Carnovali

Stark

et al. 2003

Neuropsychopharmacol

108

View full text Add to dashboard Cite

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“…A number of more recent studies have shown that mainly dopamine D 1 , but not D 2 , receptors are involved in the modulation of tasks relying on intact prefrontal cortical functioning Goldman-Rakic, 1991, 1994;Williams and Goldman-Rakic, 1995;Goldman-Rakic, 1996;Castner et al, 2000). Moreover, D 1 receptor density exceeds D 2 density by a factor of 10-20 in animal (Camps et al, 1990;Lidow et al, 1991) and human (De et al, 1988) cerebral cortex. However, there is evidence that cortical D 2 receptors are nonetheless involved in working memory performance.…”

Section: The Effect Of Haloperidol On Neuropsychological Performancementioning

confidence: 99%

Haloperidol Differentially Modulates Prepulse Inhibition and P50 Suppression in Healthy Humans Stratified for Low and High Gating Levels

Csomor

Stadler

Feldon

et al. 2007

Neuropsychopharmacol

102

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Schizophrenia patients exhibit deficits in sensory gating as indexed by reduced prepulse inhibition (PPI) and P50 suppression, which have been linked to psychotic symptom formation and cognitive deficits. Although recent evidence suggests that atypical antipsychotics might be superior over typical antipsychotics in reversing PPI and P50 suppression deficits not only in schizophrenia patients, but also in healthy volunteers exhibiting low levels of PPI, the impact of typical antipsychotics on these gating measures is less clear. To explore the impact of the dopamine D 2 -like receptor system on gating and cognition, the acute effects of haloperidol on PPI, P50 suppression, and cognition were assessed in 26 healthy male volunteers split into subgroups having low vs high PPI or P50 suppression levels using a placebocontrolled within-subject design. Haloperidol failed to increase PPI in subjects exhibiting low levels of PPI, but attenuated PPI in those subjects with high sensorimotor gating levels. Furthermore, haloperidol increased P50 suppression in subjects exhibiting low P50 gating and disrupted P50 suppression in individuals expressing high P50 gating levels. Independently of drug condition, high PPI levels were associated with superior strategy formation and execution times in a subset of cognitive tests. Moreover, haloperidol impaired spatial working memory performance and planning ability. These findings suggest that dopamine D 2 -like receptors are critically involved in the modulation of P50 suppression in healthy volunteers, and to a lesser extent also in PPI among subjects expressing high sensorimotor gating levels. Furthermore, the results suggest a relation between sensorimotor gating and working memory performance.

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“…A further clue to this question comes from Camps et al (1990) who found that D2 receptors are more abundant in the striatum than in the prefrontal cortex with a preferential distribution of D1 receptors in the prefrontal cortex. Cools (2006) elaborated on this theme by proposing that dopamine D1 receptors in the PFC enhance stability and the maintenance of cognitive representations.…”

Section: Neurochemical Modulation Of the Basal Ganglia Loopsmentioning

confidence: 99%

The basal ganglia circuits, dopamine, and ambiguous word processing: A neurobiological account of priming studies in Parkinson's disease

Chenery

Angwin

Copland

2008

J Inter Neuropsych Soc

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Research into the processing of lexical ambiguities has provided a valuable paradigm for investigating the functional architecture of the language processing system in normal and neurologically impaired populations and specifically, how basal ganglia circuits and the neurotransmitter dopamine may act to enhance and0or suppress various meanings relative to the context in which the lexical ambiguity appears. In this review, we develop the hypothesis that an integrated basal ganglia thalamocortical circuit linking the striatum and inferior frontal cortex is involved in the enhancement and suppression of ambiguous word meanings when a lexical ambiguity is presented within a linguistic context. Reference to behavioral, neurophysiological, and neurochemical studies of subcortical function in both healthy populations and people with Parkinson's disease will be used to provide further support for the proposal that the subcortex is integrally involved in ambiguous word processing. (JINS, 2008, 14, 351-364.)

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Autoradiographic localization of dopamine D1 and D2 receptors in the brain of several mammalian species

Cited by 198 publications

References 70 publications

Cocaine-Seeking Behavior in Response to Drug-Associated Stimuli in Rats: Involvement of D3 and D2 Dopamine Receptors

Cocaine-Seeking Behavior in Response to Drug-Associated Stimuli in Rats: Involvement of D3 and D2 Dopamine Receptors

Haloperidol Differentially Modulates Prepulse Inhibition and P50 Suppression in Healthy Humans Stratified for Low and High Gating Levels

The basal ganglia circuits, dopamine, and ambiguous word processing: A neurobiological account of priming studies in Parkinson's disease

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