Autoradiographische Untersuchungen �ber den Einflu� von Cyclophosphamid (Endoxan) auf die DNS-Synthese proliferierender Zellsysteme der Maus

Cell Proliferation in Leukemia During Relapse and Remission

“…It has been found, for example, that actinomycin D inhibits primarily RNA synthesis in certain cell systems (12) or, specifically, the DNA-dependent RNA syn thesis (14-16) and DNA replication itself only secondarily. Other drugs, like 6-mercaptopurine or cyclophosphamide, affect mainly the metabolism of DNA itself (17,18), the exact mechanism being unknown. Conversely, hydrocortisone was found to induce an in crease in DNA synthesis and mitotic index (19).…”

Zytostatikawirkungen auf die Nukleinsäure-und Proteinsynthese von benignen und malignen Lymphomen

“…Das kann einmal daran liegen, dass Stickstofflost ausser der DNS-und RNS-Synthese noch andere Angriffsmöglich keiten in der Zelle hat, kann aber auch darauf beruhen, dass das Me dikament die bei der Lymphadenose stark vermehrten kleinen Lym phozyten vernichtet, während die ohnehin bei dieser Krankheit ge ringe Proliferation (50) Das bei der Lymphogranulomatose oft sehr wirksame Vinblastin hatte keinen Effekt auf die DNS-oderRNS-Synthese. Das entspricht den Erwartungen, denn Vinblastin ist nach den Untersuchungen von Boggs et al (8) und Bruchowsky et al (11) (1,7,35,38,39,43,53,54 Summary DN'A, RNA and protein synthesis of 26 lymphomas (8 cases of Hodgkin's disease, 5 cases of reticulum cell sarcoma, 4 cases of lymphatic leukaemia and 9 cases of lymphatic hyperplasia) were determined in vitro after 1 hour incubation with some cytostatic agents. Natulan reduced DNA synthesis in 14 out of 22 cases, less frequently RNA and protein synthesis.…”

The effect of triethylene melamine on DNA synthesis and mitosis in the lens epithelium

“…Microspectrophotometric measurements and grain counts showed that there was a brief stimulation of the rate of DNA synthesis followed by severe impairment of the progress of these cells toward the G2 period. Another type of alkylating agent, cyclophosphamide, was reported to diminish the rate of incorporation of H3-thymidine and the total number of labeled cells in the intestinal epithelium and other tissues of the mouse, (PALME & LISS 1963). Myleran, which severely inhibited the mitotic process in the rat lens epithelium did not directly affect DNA synthesis (GRIMES et al 1964).…”