1957
DOI: 10.1038/180983a0
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Autoradiography of Polytene Chromosomes of Rhynchosciara angelae at Different Stages of Larval Development

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Cited by 167 publications
(36 citation statements)
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“…There was no evidence of an immediate connection or direct connection between cells with weakly labelled nuclei and cells with heavily labelled nuclei. Pelc identified strong relationships between the presence of the weakly and heavily labelled nuclei to a similar occurrence observed by Ficq and Pavan [133], where considerable incorporation of tritiated thymidine into certain bands of polytene chromosomes of Rhynchosciara angelae occurred during the enlargement of the bands at certain steps of development. The ''puffing'' of the bands is due to a different activity of the genes at different times in the larval development and may occur similarly in the differentiated cells of mammalian organs.…”
Section: The Discovery Of Dna With Metabolic Activitysupporting
confidence: 80%
“…There was no evidence of an immediate connection or direct connection between cells with weakly labelled nuclei and cells with heavily labelled nuclei. Pelc identified strong relationships between the presence of the weakly and heavily labelled nuclei to a similar occurrence observed by Ficq and Pavan [133], where considerable incorporation of tritiated thymidine into certain bands of polytene chromosomes of Rhynchosciara angelae occurred during the enlargement of the bands at certain steps of development. The ''puffing'' of the bands is due to a different activity of the genes at different times in the larval development and may occur similarly in the differentiated cells of mammalian organs.…”
Section: The Discovery Of Dna With Metabolic Activitysupporting
confidence: 80%
“…Also contributing to the doubts about Pavan's findings was the factor that no similar process had ever been seen in salivary gland chromosomes of other dipterans such as Drosophila and Chironomus. Some years later in collaboration with Adrianne Ficq, autoradiographic data using tritiated thymidine (Ficq and Pavan 1957) confirmed that differential DNA synthesis in specific puffs was indeed occurring, as he had described previously. Many years later, the occurrence of gene amplification was widened when this process was characterised in other cell types subjected to either normal or abnormal growth.…”
supporting
confidence: 67%
“…Much of the recent interest in the metabolic activity of DNA has centered in studies on the giant polytene chromosomes of Dipteran larvae (5,10,40,42). Certain bands on these chromosomes show a disproportionate local increase in DNA content at the time of "puffing" or Balbiani ring formation.…”
Section: Resultsmentioning
confidence: 99%