Autoreactive antibodies against neurons and basal lamina found in serum following experimental brain contusion in rats

Rudehill, S.; Muhallab, Saad; Wennersten, André; Gertten, Christina von; Nimer, Faiez Al; Sandberg-Nordqvist, Ann-Christin; Holmin, Staffan; Mathiesen, Tiit

doi:10.1007/s00701-005-0673-5

Cited by 27 publications

(19 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…However, none of these mechanisms have been proven, and the mechanism of sports-related head trauma-induced pituitary dysfunction is still unclear. A possible role of autoimmunity has been suggested by studies conducted in animals, which demonstrated naturally occurring IgG autoantibodies against dying neurons in the injured brain of adult rats following a cortical lesion (13) and autoreactive antibodies against neurons and basal lamina in the serum of rats submitted to experimental TBI (14). Supporting these experimental findings, a significant association between antipituitary antibody (APA) positivity and hypopituitarism 3 years after TBI has been clearly demonstrated in a very recent clinical study (15).…”

Section: Introductionmentioning

confidence: 87%

See 1 more Smart Citation

Investigation of antihypothalamus and antipituitary antibodies in amateur boxers: is chronic repetitive head trauma-induced pituitary dysfunction associated with autoimmunity?

Tanrıverdi¹,

Bellis²,

Battaglia³

et al. 2010

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Current data clearly demonstrate that sports-related chronic repetitive head trauma due to boxing might result in hypopituitarism. However, the mechanism of sports-related traumatic brain injury-induced pituitary dysfunction is still unclear. In order to understand whether autoimmune mechanisms could play a role in the pituitary dysfunction due to sports-related head trauma, we investigated the presence of antipituitary antibodies (APAs) and antihypothalamus antibodies (AHAs) in amateur boxers. Patients and design: Sixty-one actively competing (nZ44) or retired (nZ17) male boxers (mean age, 26 years; range, 17-53) who had been evaluated regarding pituitary functions previously were included in the study. In all boxers and in 60 age/sex-similar normal controls, AHAs and APAs were investigated by an indirect immunofluorescence method. Results: AHAs were detected in 13 of 61 boxers (21.3%), and APAs were detected in 14 of 61 boxers (22.9%), but in none of the normal controls. Pituitary dysfunction was significantly higher in AHApositive boxers (46.2%) than in AHA-negative boxers (10.4%) (PZ0.003). There was a significant association between AHA positivity and hypopituitarism due to boxing (odds ratio: 7.37, 95% confidence interval 1.8-30.8). There was no significant association between APA positivity and hypopituitarism. Conclusions: This study demonstrates for the first time the presence of AHAs and APAs in boxers who were exposed to sports-related head trauma. Moreover, the present investigation provides preliminary evidence that AHAs are associated with the development of pituitary dysfunction in boxers, thus suggesting that autoimmunity may have a role in the pathogenesis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

Investigation of antihypothalamus and antipituitary antibodies in amateur boxers: is chronic repetitive head trauma-induced pituitary dysfunction associated with autoimmunity?

Tanrıverdi¹,

Bellis²,

Battaglia³

et al. 2010

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Furthermore, autoreactive antibodies against neurons and basal lamina have been found in serum following experimental TBI in rats. The authors concluded that the presence of autoreactive antibodies against neurons and basal lamina after TBI could play a pathogenic role in the delayed neuron degeneration (8). Even if studies in humans investigating the occurrence of APA in patients with TBI are lacking in the literature, these antibodies have been detected in patients with selective idiopathic hypopituitarism and in adults with autoimmune endocrine diseases (9,11,13).…”

Section: Discussionmentioning

confidence: 99%

“…However, the dynamic changes in pituitary function suggest that head trauma may trigger an ongoing process such as autoimmunity (4). A possible role of autoimmunity could be suggested by studies in animals that demonstrated naturally occurring IgG autoantibodies against dying neurons in the injured brain of adult rats following a cortical lesion (7) and autoreactive antibodies against neurons and basal lamina in the serum of rats submitted to experimental TBI (8). Although the antibodies against neurons have been demonstrated in injured animal studies, investigations regarding the occurrence of antipituitary antibodies (APAs) in patients with TBI are lacking in the literature.…”

Section: Introductionmentioning

confidence: 99%

Antipituitary antibodies after traumatic brain injury: is head trauma-induced pituitary dysfunction associated with autoimmunity?

Tanrıverdi

Bellis²,

Bizzarro³

et al. 2008

European Journal of Endocrinology

133

View full text Add to dashboard Cite

Objective: Traumatic brain injury (TBI) is a devastating public health problem that may result in hypopituitarism. However, the mechanisms responsible for hypothalamic-pituitary dysfunction due to TBI are still unclear. Although the antibodies against neurons have been demonstrated in injured animal studies, investigations regarding the occurrence of antipituitary antibodies (APAs) in patients with TBI are lacking in the literature. In order to investigate whether autoimmune mechanisms could play a role in the pituitary dysfunction after TBI, we have planned this study aimed at investigating the presence of APA at the third year of TBI and association between the TBI-induced hypopituitarism and APA. Patients and design: Twenty-nine (25 males and 4 females; age 36.5G2.3 years) patients who had completed a 3-year follow-up after TBI were included in the present study. APA and pituitary function were evaluated in all the patients 3 years after TBI; moreover, APAs were tested also in sera of 60 age-/sexmatched normal controls. The APAs were investigated by an indirect immunofluorescence method. Results: APAs were detected in 13 out of the 29 TBI patients (44.8%), but in none of the normal controls. Pituitary dysfunction development ratio was significantly higher in APA-positive patients (46.2%) when compared with APA-negative ones (12.5%; PZ0.04). There was a significant association between APA positivity and hypopituitarism due to TBI (odds ratio: 2.25, 95% confidence intervals 1.1-4.6). Moreover, there was a significant positive correlation (rZ0.74, PZ0.004) between APA titer ratio and peak GH response to GHRHCGH related peptide (GHRP)-6 test, suggesting that high APA titers were associated with low GH response to GHRHCGHRP-6 test. Conclusions: This study shows for the first time the presence of the APA in TBI patients 3 years after head trauma. Moreover, present investigation indicates preliminary evidence that APA may be associated with the development of TBI-induced pituitary dysfunction, thus suggesting that autoimmunity may contribute in the development of TBI-induced hypopituitarism. The presence of the association between APA and TBIinduced hypopituitarism may provide a new point of view in this field and promote further clinical and experimental studies.European Journal of Endocrinology 159 7-13

show abstract

“…16,46 Also, animal studies have shown a possible role of autoimmunity involving the hypothalamic-pituitary region and triggered by head trauma. 54,59 In a preliminary study, in 2008, Tanriverdi et al 61 investigated the presence of APAs in 29 patients with TBI 3 years after head trauma, and in 60 age-and sex-matched normal controls. The APAs were detected in 44.8% of TBI patients but in none of the controls.…”

Section: Antibodies Theorymentioning

confidence: 99%

Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction

Dubourg

Messerer

2011

FOC

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is recognized as a cause of hypopituitarism even after mild TBI. Although over the past decade, a growing body of research has detailed neuroendocrine changes induced by TBI, the mechanisms and risk factors responsible for this pituitary dysfunction are still unclear. Around the world, sports—especially combative sports—are very popular. However, sports are not generally considered as a cause of TBI in most epidemiological studies, and the link between sports-related head trauma and hypopituitarism has not been investigated until recently. Thus, there is a paucity of data regarding this important concern. Because of the large number of young sports participants with near-normal life expectancy, the implications of undiagnosed or untreated postconcussion pituitary dysfunction can be dramatic. Understanding the pathophysiological mechanisms and risk factors of hypopituitarism caused by sports injuries is thus an important issue that concerns both medical staff and sponsors of sports. The aim of this paper was to summarize the best evidence for understanding the pathophysiological mechanisms and to discuss the current data and recommendations on sports-related head trauma as a cause of hypopituitarism.

show abstract

Autoreactive antibodies against neurons and basal lamina found in serum following experimental brain contusion in rats

Cited by 27 publications

References 35 publications

Investigation of antihypothalamus and antipituitary antibodies in amateur boxers: is chronic repetitive head trauma-induced pituitary dysfunction associated with autoimmunity?

Investigation of antihypothalamus and antipituitary antibodies in amateur boxers: is chronic repetitive head trauma-induced pituitary dysfunction associated with autoimmunity?

Antipituitary antibodies after traumatic brain injury: is head trauma-induced pituitary dysfunction associated with autoimmunity?

Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction

Contact Info

Product

Resources

About