Autoreactive isotype-specific T cells determine B cell frequency

Granucci, Francesca; Tota, Francesco P. Di; Raimondi, Giorgio; Citterio, Stefania; Rescigno, María; Ricciardi‐Castagnoli, Paola

doi:10.1002/1521-4141(200101)31:1<215::aid-immu215>3.0.co;2-4

Cited by 4 publications

(9 citation statements)

References 36 publications

(10 reference statements)

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“…Moreover, this observation, although made in an in-fact artificial model system, could explain how T cells responsible for inducing HSK are tolerized in peripheral lymphoid organs in nonsusceptible mice. We have previously shown that T cells expressing a high density of the TCR specific for the Bpep are not subjected to central tolerization and reach lymph nodes as functional cells in Ighb mice (9). Keratogenic T cells cross-recognize the Bpep and a not-yet identified peptide in the cornea (10).…”

Section: Discussionmentioning

confidence: 99%

“…We have previously shown that T cells expressing at high density a TCR specific for the 435-451 peptide (Bpep) in the CH3 region of the IgG2a b are not deleted in the thymus of Ighb animals (which produce IgG2a b ) and reach peripheral lymphoid organs (9). Nevertheless, there are some evidences that peripheral anti-IgG2a b T cells can become tolerant.…”

Section: Induction Of Peripheral T Cell Tolerance Bymentioning

confidence: 99%

“…The Tg animals were obtained in different backgrounds: BALB/c, expressing the a and not the b allotype of IgG2a; CB-17 expressing the IgG2a b ; and TCR ␣-chain-deficient knockout (KO) BALB/c (␣KOTg ϩ b Ϫ ) and CB-17 (␣KOTg ϩ b ϩ ), to exclude endogenous ␣ rearrangements (9). TCR ␣-chain-deficient BALB/c mice were the source of naive 2a T cells used in this work.…”

Section: Mice and Experimental Modelmentioning

confidence: 99%

“…In ␣KOTg ϩ b Ϫ mice around 34% of total CD4 ϩ cells in blood, lymph nodes, and spleen expressed the Tg TCR (9). The remaining CD4 ϩ population was TCR-negative or expressed endogenous ␤-chains.…”

Section: Transitoriness Of Ag Presentation In Steady State Conditionsmentioning

confidence: 99%

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Induction of Peripheral T Cell Tolerance by Antigen-Presenting B Cells. I. Relevance of Antigen Presentation Persistence

Raimondi

Zanoni

Citterio

et al. 2006

The Journal of Immunology

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Various mechanisms of peripheral T cell tolerization have evolved to avoid responses mediated by autoreactive T cells that have not been eliminated in the thymus. In this study, we investigated the peripheral conditions of Ag presentation required to induce T cell tolerance when the predominant APCs are B cells. We show that transient Ag presentation, in absence of inflammation and in a self-context, induces CD4+ T cell activation and memory formation. In contrast, chronic Ag presentation leads to CD4+ T cell tolerance. The importance of long-lasting Ag presentation in inducing tolerance was also confirmed in the herpes stromal keratitis autoimmune disease model. Keratogenic T cells could be activated or tolerized depending on the APC short or long persistence. Thus, when APCs are B cells, the persistence of the Ag presentation itself is one of the main conditions to have peripheral T cell tolerance.

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Section: Discussionmentioning

confidence: 99%

Section: Induction Of Peripheral T Cell Tolerance Bymentioning

confidence: 99%

Section: Mice and Experimental Modelmentioning

confidence: 99%

Section: Transitoriness Of Ag Presentation In Steady State Conditionsmentioning

confidence: 99%

See 2 more Smart Citations

Induction of Peripheral T Cell Tolerance by Antigen-Presenting B Cells. I. Relevance of Antigen Presentation Persistence

Raimondi

Zanoni

Citterio

et al. 2006

The Journal of Immunology

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“…In a previous work, we have shown that the functionality of 2a T cells matured in CB-17 mice (presenting the cognate Ag) differed depending on whether they were kept in sterile or dirty housing conditions (25). Although no T cells responded to peptide under sterile conditions, some T cell responsiveness was observable after 3 mo of dirty housing or immunization and led to in vitro proliferation and suppression of serum IgG2a b .…”

Section: Discussionmentioning

confidence: 93%

Induction of Peripheral T Cell Tolerance by Antigen-Presenting B Cells. II. Chronic Antigen Presentation Overrules Antigen-Presenting B Cell Activation

Raimondi

Zanoni

Citterio

et al. 2006

The Journal of Immunology

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Ag presentation in the absence of danger signals and Ag persistence are the inductive processes of peripheral T cell tolerization proposed so far. Nevertheless, it has never been definitively shown that chronic Ag presentation per se can induce T cell tolerance independent of the state of activation of APCs. In the present work, we investigated whether chronic Ag presentation by either resting or activated B cells can induce tolerance of peripheral Ag-specific T cells. We show that CD4+ T cells that re-encounter the Ag for a prolonged period, presented either by resting or activated Ag-presenting B cells, become nonfunctional and lose any autoimmune reactivity. Thus, when the main APCs are B cells, the major mechanism responsible for peripheral T cell tolerization is persistent Ag exposure, independent of the B cell activation state.

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T-cell receptor transgenic mice in the study of autoimmune diseases

Lafaille¹

2004

Journal of Autoimmunity

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Autoreactive isotype-specific T cells determine B cell frequency

Cited by 4 publications

References 36 publications

Induction of Peripheral T Cell Tolerance by Antigen-Presenting B Cells. I. Relevance of Antigen Presentation Persistence

Induction of Peripheral T Cell Tolerance by Antigen-Presenting B Cells. I. Relevance of Antigen Presentation Persistence

Induction of Peripheral T Cell Tolerance by Antigen-Presenting B Cells. II. Chronic Antigen Presentation Overrules Antigen-Presenting B Cell Activation

T-cell receptor transgenic mice in the study of autoimmune diseases

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