Autorecycling oxidation of alcohols catalysed by pyridodipyrimidines as an NAD(P)+ model

Antitumor studies. Part 4: Design, synthesis, antitumor activity, and molecular docking study of novel 2-substituted 2-deoxoflavin-5-oxides, 2-deoxoalloxazine-5-oxides, and their 5-deaza analogs

“…In our previous publications, [1][2][3][4][5][6] a series of synthesized 2-phenylflavin-5-oxide and 2-phenyl-5-deazaflavin analogs (Scheme 1) has been reported for their in vitro significant antitumor activities against different tumor cell lines. Compounds comprising flavin-N-oxides have been recently used for treatments of solid tumors, non-solid tumor masses, leukemia, and non-small cell lung cancers involving in situ activator mixed with the flavin-N-oxide for a period of time, results in damage to the DNA in the cancer cells without substantial damage to the DNA of normal cells.…”

Development of a Water-Mediated and Catalyst-Free Green Protocol for Easy Access to a Huge Array of Diverse and Densely Functionalized Pyrido[2,3-d:6,5-d′]dipyrimidines via One-Pot Multicomponent Reaction under Ambient Conditions

“…Among N -heterocycles, pyrimidine and its derivatives are reported for a wide range of biological profiles including antioxidant, anti-inflammatory, immunomodulating, antibacterial, antiviral, and antitumor activity. − Categorically, barbituric/2-thiobarbituric acids, an important class of pharmaceutically promising pyrimidine derivatives, find potential applications as building blocks for a series of barbiturate/thiobarbiturate drugs used as hypnotics, sedatives, anticonvulsants, anesthetics, antioxidants, antifungal, and as CNS depressants. − Combination of barbituric/thiobarbituric acid moiety with other pharmacophoric groups, thus, may offer a possibility to synthesize numerous derivatives with desired potential biological effects. With this view, pyrimidine-fused pyridines, especially pyrido­[2,3- d ]­pyrimidines, have been studied intensively over the recent past due to their wide spectrum of promising biological activities. − Among various tricyclic pyrimido­pyrido­pyrimidines, the pyrido­[2,3- d :6,5- d ′]­dipyrimidine scaffold has attracted much attention because a handful of such derivatives possess considerable α-glucosidase and α-amylase inhibitory activity, antibacterial, , antiviral, NAD-type redox catalytic, and anticorrosive , properties. In addition, such a scaffold has been reported to have the potential in self-assembling to constitute supramolecular structure as well …”

Synthetic strategy toward 1,9‐functionalized pyrido[2,3‐d:6,5‐d′]dipyrimidine‐2,4,6,8‐tetrones

“…Pyrido[2,3‐ d :6,5‐ d ′]dipyrimidine‐2,4,6,8‐tetrones (PDP) 4 illustrated in Scheme are an interesting class of biannulated pyridine compounds. Derivatives of 4 have been shown to exhibit antibacterial and antiviral properties [1] as well as NAD‐type redox catalytic activity [2]. Solid‐state ribbons have also been described from the self‐assembly of an amine derivative of 4 , which demonstrates the potential of these heterocyclic compounds in supramolecular synthesis applications [3].…”