“…Heterocycles with pyridodipyrimidine cores are fascinating compounds owing to their resilient oxidizing aptitude [ 37 ]. Al-Hassan et al [ 38 ] synthesized 10-D-ribitylpyridodipyrimidine-tetraone 1 in relatively low yield (21%) by reaction of 6-D-ribitylaminopyrimidine-dione with triethyl orthoformate in refluxing ethanol (Eq.…”
Section: Brief History Of Pyridodipyrimidine Class Of Compoundsmentioning
confidence: 99%
“…In another route, pyrido-dipyrimidines were synthesized in 66–95% yields by reactions of 2-methyl-6-(substituted-amino)pyrimidin-4(3 H )-one with 2,4,6-trichloropyrimidine-5-carbaldehyde in refluxing acetic acid [ 53 ]. Alternatively, a series of tri-substituted-pyrido-dipyrimidine-tetraones were synthesized by reactions of 3-substituted-6-(substituted-amino) pyrimidine-2,4(1 H ,3 H )-diones with 6-chloro-3-substituted-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehydes [ 37 ]. Scheme 5 Synthesis of tricyclic pyridodipyrimidines …”
Section: Brief History Of Pyridodipyrimidine Class Of Compoundsmentioning
The entitled review aimed to assemble and highlight the synthetic approaches and biological aspects of heterocycles with pyridodipyrimidine motifs. The recent synthetic approaches were categorized according to the accomplishments of the approaches under catalyst or catalyst-free conditions. The topic involved the synthesis of substituted tricyclic systems and spirocyclic systems. The present study offered an overview of the recent literature in addition to a scope of the preceding literature. The proposed mechanisms of the varied target products were discussed. Pyridodipyrimidine displayed potential and privileged cytotoxic, antioxidant, and antimicrobial performances. The competitions, challenges, and prospects are also deliberated.
“…Heterocycles with pyridodipyrimidine cores are fascinating compounds owing to their resilient oxidizing aptitude [ 37 ]. Al-Hassan et al [ 38 ] synthesized 10-D-ribitylpyridodipyrimidine-tetraone 1 in relatively low yield (21%) by reaction of 6-D-ribitylaminopyrimidine-dione with triethyl orthoformate in refluxing ethanol (Eq.…”
Section: Brief History Of Pyridodipyrimidine Class Of Compoundsmentioning
confidence: 99%
“…In another route, pyrido-dipyrimidines were synthesized in 66–95% yields by reactions of 2-methyl-6-(substituted-amino)pyrimidin-4(3 H )-one with 2,4,6-trichloropyrimidine-5-carbaldehyde in refluxing acetic acid [ 53 ]. Alternatively, a series of tri-substituted-pyrido-dipyrimidine-tetraones were synthesized by reactions of 3-substituted-6-(substituted-amino) pyrimidine-2,4(1 H ,3 H )-diones with 6-chloro-3-substituted-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehydes [ 37 ]. Scheme 5 Synthesis of tricyclic pyridodipyrimidines …”
Section: Brief History Of Pyridodipyrimidine Class Of Compoundsmentioning
The entitled review aimed to assemble and highlight the synthetic approaches and biological aspects of heterocycles with pyridodipyrimidine motifs. The recent synthetic approaches were categorized according to the accomplishments of the approaches under catalyst or catalyst-free conditions. The topic involved the synthesis of substituted tricyclic systems and spirocyclic systems. The present study offered an overview of the recent literature in addition to a scope of the preceding literature. The proposed mechanisms of the varied target products were discussed. Pyridodipyrimidine displayed potential and privileged cytotoxic, antioxidant, and antimicrobial performances. The competitions, challenges, and prospects are also deliberated.
“…Method A: Using the procedure described for the synthesis of compound 6 (method A), compounds 12a -e were prepared by reaction of equmolar amounts of 1 with the appropriate benzaldehyde derivatives 2 and thiobarbituric acid (10) with microwave heating at 800 Watt for 4 -7 min. The products were recrystallized from DMF/MeOH.…”
Section: Synthesis Of 10-aryl-1368-tetrahydro-7-thioxopyrido[32-dmentioning
An efficient and direct procedure for the synthesis of pyrido [3,2-d:6,5-d ]dipyrimidine derivatives under microwave-assisted conditions is been described. The structures of the products were characterized by elemental analyses, and their IR, 1 H NMR, 13 C NMR, and MS spectra.
“…In relation to our studies on the biomimetic oxidations mediated by 5-deazaflavins and analogues [ 11, we have recently found that some pyridodipyrimidines showed strong ability and remarkable autorecycling toward oxidation of alcohols [2]. The pyridodipyrimidines are the structurally cyclized compounds of the amino analogues of the Hantzsch esters and have a conjugated system similar to that of ~-deazaflavins.…”
A new-type pyridodipyrimide, 8-methylpyrido[2,3-d:6,5-d'Jdipyrimidine-2,4,6(3H, lOH,7fltriones were prepared by the condensation of 6-alkylor 6-aryl-amin0-2-methyIpyrimidin-ly3Htones with 2,4,6-trichloropyrimidine-5-carbaldehyde or 3-alkyl-6-chloro-5-formyIuracils. The pyridodipyrimidines thus obtained oxidized alcohols under neutral conditions to yield the corresponding carbonyl compounds and a significant autorecycling in the oxidation was observed.
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