Autoregulation in paediatric TBI—current evidence and implications for treatment

Donnelly, Joseph E.; Young, Adam M. H.; Brady, Ken

doi:10.1007/s00381-017-3523-x

Cited by 20 publications

(14 citation statements)

References 60 publications

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“…Although SEGAs are slow-growth tumors (WHO Grade I) [ 7 ], they are responsible for about 25% of mortalities associated with TSC. This percentage levels up to 50% when acute hydrocephalus and intratumor hemorrhage assault [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Late Manifestation of Subependymal Giant Cell Astrocytoma With Hydrocephalus in an Adult Patient With Tuberous Sclerosis Complex

Addeen¹,

Yehia²,

Aburas³

et al. 2022

Cureus

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Subependymal giant cell astrocytoma (SEGA) is a unique brain tumor that constitutes one of the major diagnostic criteria of tuberous sclerosis complex (TSC). It rarely occurs de novo after adolescence. SEGA tends to originate from the ventricular walls, provoking obstructive hydrocephalus, raised intracranial pressure, and papilledema with plausible visual problems. We present a case of large SEGA in a 33-year-old-TSC patient with a higher-than-expected age for the first presentation. His chief complaint was visual acuity deterioration combined with headaches. Microsurgical removal of the tumor was carried out. Obstructive hydrocephalus and papilledema resolved after treatment. Although SEGA-TSC is considered a tumor of children and adolescents, it can present for the first time in adulthood. In TSC patients, periodic imaging follow-up is recommended and any visual symptoms should prompt exclusion of intracranial tumors.

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Section: Discussionmentioning

confidence: 99%

Late Manifestation of Subependymal Giant Cell Astrocytoma With Hydrocephalus in an Adult Patient With Tuberous Sclerosis Complex

Addeen¹,

Yehia²,

Aburas³

et al. 2022

Cureus

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“…TBI remains a significant clinical challenge in spite of several breakthroughs of trauma management strategies in recent years (Donnelly, Young, & Brady, 2017). The incidence of TBI is up to 2% ‐ 3% in the industrialized countries in Europe, and it has ranked as one of the leading causes of morbidity and mortality of adolescent and adults under 40 years of age all over the world (Bomyea, Lang, & Schnurr, 2017).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats

et al. 2020

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“…TBI is a global issue that severely affects public health and social economy [14,15]. It is estimated that about 52,000 people die from TBI in the United States each year, and about 530,000 people are disabled by it [16].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Aquaporin-4 Deficiency on Longer-Term Neurological Outcomes in a Mouse Model of Traumatic Brain Injury

Liu

Xie

Wan

et al. 2020

Preprint

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Background: Traumatic brain injury (TBI) has been a crucial health problem, with more than 50 million patients worldwide each year. Glymphatic system is a fluid exchange system that relies on the polarized water channel aquaporin-4 (AQP4) at the astrocytes, accounting for the clearance of abnormal proteins and metabolites from brain tissues. However, the dysfunction of glymphatic system and alteration of AQP4 polarization during the progression of TBI remain unclear.Methods: AQP4−/− and Wild Type (WT) mice were used to establish the TBI mouse model respectively. Morris water maze (MWM) was used to establish the cognitive functions of AQP4−/− and WT mice post TBI. Western-blot and qRT-PCR assays were performed to demonstrate protective effects of AQP4 deficiency to blood-brain barrier (BBB) integrity and amyloid-β clearance. The inflammation of cerebral tissues post TBI was estimated by ELISA assay.Results: AQP4 deficiency alleviated the brain edema and neurological deficit in TBI mice. AQP4-knockout led to improved cognitive outcomes in mice post TBI. The BBB integrity and cerebral amyloid-β clearance were protected by AQP4 deficiency in TBI mice. AQP4 deficiency ameliorated the TBI-induced inflammation.Conclusion: AQP4 deficiency improved longer-term neurological outcomes in a mouse model of TBI.

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Autoregulation in paediatric TBI—current evidence and implications for treatment

Cited by 20 publications

References 60 publications

Late Manifestation of Subependymal Giant Cell Astrocytoma With Hydrocephalus in an Adult Patient With Tuberous Sclerosis Complex

Late Manifestation of Subependymal Giant Cell Astrocytoma With Hydrocephalus in an Adult Patient With Tuberous Sclerosis Complex

Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats

Protective Effects of Aquaporin-4 Deficiency on Longer-Term Neurological Outcomes in a Mouse Model of Traumatic Brain Injury

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