Autoregulation of Cerebral Blood Flow During Controlled Hypotension

Fitch, W.; Ferguson, G. G.; Sengupta, D.; Garibi, Jesús Herrero

doi:10.1007/978-3-642-65814-3_5

Cited by 14 publications

(14 citation statements)

References 12 publications

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“…13 When testing the autoregulatory function in 16 long-term diabetics, we found four patients with statistically non-horizontal curves (Cases 1, 2, 3, and 5). One of these patients (Case 1) was reexamined five months later, again resulting in a non-horizontal curve.…”

Section: Discussionmentioning

confidence: 82%

“…Eklof et al (1971) 12 showed that surgical sympathectomy two weeks prior to the study had no influence on the autoregulatory function in monkeys. Fitch et al 13 have recently shown that in baboons acute surgical and pharmacological sympathectomy causes only a shift to the left of the lower autoregulatory limit, which rather constitutes an improvement of autoregulatory capacity.…”

Section: Coumal Automoulation In Diautis 'Average -Average Fiouhmentioning

confidence: 99%

“…Autoregulation is only operating in a certain blood pressure interval around the resting mean arterial blood pressure (MABP), breaking down at a lower and upper limit. At the lower limit, which is 60 to 70 mm Hg MABP for a normotensive person with a resting MABP of about 90 mm Hg, 13 CBF begins to decrease, but sufficient oxygen supply is still ensured by an increase in the arteriovenous (AV) oxygen extraction. At still lower blood pressures (for a normotensive person about 35 to 40 mm Hg) also this mechanism fails, and cerebral hypoxia develops.…”

Section: Introductionmentioning

confidence: 99%

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Chronically Impaired Autoregulation of Cerebral Blood Flow in Long-Term Diabetics

Bentsen

Larsen

Lassen

1975

Stroke

110

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Abstract:Chronically Impaired Autoregulation of Cerebral Blood Flow in Long-Term Diabetics • Using the arteriovenous oxygen difference method autoregulation of cerebral blood flow (CBF) was tested in 16 long-term diabetics and eight control patients. Blood pressure was raised by angiotensin infusion and lowered by trimethaphan camsylate infusion, in some cases combined with head-up tilting of the patient. Regression analysis was carried out on the results in order to quantify autoregulatory capacity.In the control patients CBF did not vary with moderate blood pressure variations, indicating normal autoregulation. In four of the 16 diabetic patients CBF showed significant pressure dependency, indicating impaired autoregulation. The cause of impaired autoregulation in some long-term diabetics is believed to be diffuse or multifocal dysfunction of cerebral arterioles due to diabetic vascular disease. Other conditions with impaired autoregulation are discussed and compared with that seen in long-term diabetes.

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Section: Discussionmentioning

confidence: 82%

Section: Coumal Automoulation In Diautis 'Average -Average Fiouhmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chronically Impaired Autoregulation of Cerebral Blood Flow in Long-Term Diabetics

Bentsen

Larsen

Lassen

1975

Stroke

110

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“…In the normal state regional or total CBF remains relatively constant within moderate limits of systemic arterial blood pressure. However, if systolic pressure is greater than 140 mm Hg 2 or less than 70 mm Hg, 3 CBF may increase or decrease, respectively. PAR is said to be preserved if CBF does not change in response to fluctuations of mean arterial blood pressure (MABP) within this range.…”

Section: Introductionmentioning

confidence: 99%

“…Diazoxide, a rapidly acting non-diuretic benzothiadiazine derivative, has been used extensively in the treatment of hypertensive emergencies. 3 ' * It has been shown that diazoxide reverses the contractions produced in isolated vascular segments by agents with such diverse mode of action as norepinephrine, vasopressin and barium chloride' and that the action of diazoxide is not modified by betablockade with propranolol 8 ; therefore, it has been postulated…”

mentioning

confidence: 99%

Neurogenic Regulation of Cerebral Blood Flow Following Ischemia

Zervas

Hori

Nagoro

et al. 1976

Stroke

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113The distinction between intracerebral hematoma and cerebral infarction can be made only by CT.Three observations in this study indicate complementary roles for RN brain imaging and CT in evaluation of patients with stroke. (1) While the percentages of abnormalities on both tests were comparable in recent infarction, the results in the same patients were not identical in 55% of the cases.(2) In patients with a recent and an old stroke a positive RN uptake would be the result of the recent insult, while on CT both types of lesions show similar abnormalities. (3) Hemodynamic changes on rapid sequence studies were demonstrated in 38% of 18 patients on whom the test was done.

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The Innervation of Pial Blood Vessels and their Role in Cerebrovascular Regulation

Macfarlane¹,

Moskowitz²

1995

Brain Ischemia

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Autoregulation of Cerebral Blood Flow During Controlled Hypotension

Cited by 14 publications

References 12 publications

Chronically Impaired Autoregulation of Cerebral Blood Flow in Long-Term Diabetics

Chronically Impaired Autoregulation of Cerebral Blood Flow in Long-Term Diabetics

Neurogenic Regulation of Cerebral Blood Flow Following Ischemia

The Innervation of Pial Blood Vessels and their Role in Cerebrovascular Regulation

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