Autoregulation of cochlear blood flow

Kawakami, Michiro; Makimoto, Kazuo; Fukuse, Shinya; Takahashi, Hiroaki

doi:10.1007/bf00627636

Cited by 29 publications

(5 citation statements)

References 11 publications

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“…The effects of hypotension can also be enhanced by the reduced ability for autoregulation of the inner ear circulation compared with cerebral blood flow. 20 As reported before, a similar pathophysiological mechanism has been hypothesized 8,12 in most patients with Meniere disease who have a combination of systemic hypotension and a history of stress: this could elicit a situation of exaggerated sympathetic activation involving the inner ear circulation. This is why responders to glycerol infusion were included in this series; on the other hand, an osmotic mechanism could feasibly be responsible for peripheral vasodilation.…”

Section: Commentmentioning

confidence: 84%

Systemic Hypotension and the Development of Acute Sensorineural Hearing Loss in Young Healthy Subjects

Pirodda¹,

Ferri²,

Modugno³

et al. 2001

Arch Otolaryngol Head Neck Surg

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Section: Commentmentioning

confidence: 84%

Systemic Hypotension and the Development of Acute Sensorineural Hearing Loss in Young Healthy Subjects

Pirodda¹,

Ferri²,

Modugno³

et al. 2001

Arch Otolaryngol Head Neck Surg

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“…In vivo measurements of cochlear blood flow revealed that flow is largely maintained in the face of variant blood pressures [14], [15] although, the autoregulatory response of cochlear blood flow was weaker compared to cortical flow [16]. The question, where do autoregulatory mechanisms exist along the vascular tree supplying the cochlea, remained undetermined.…”

Section: Introductionmentioning

confidence: 99%

Gender Differences in Myogenic Regulation along the Vascular Tree of the Gerbil Cochlea

et al. 2011

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Regulation of cochlear blood flow is critical for hearing due to its exquisite sensitivity to ischemia and oxidative stress. Many forms of hearing loss such as sensorineural hearing loss and presbyacusis may involve or be aggravated by blood flow disorders. Animal experiments and clinical outcomes further suggest that there is a gender preference in hearing loss, with males being more susceptible. Autoregulation of cochlear blood flow has been demonstrated in some animal models in vivo, suggesting that similar to the brain, blood vessels supplying the cochlea have the ability to control flow within normal limits, despite variations in systemic blood pressure. Here, we investigated myogenic regulation in the cochlear blood supply of the Mongolian gerbil, a widely used animal model in hearing research. The cochlear blood supply originates at the basilar artery, followed by the anterior inferior cerebellar artery, and inside the inner ear, by the spiral modiolar artery and the radiating arterioles that supply the capillary beds of the spiral ligament and stria vascularis. Arteries from male and female gerbils were isolated and pressurized using a concentric pipette system. Diameter changes in response to increasing luminal pressures were recorded by laser scanning microscopy. Our results show that cochlear vessels from male and female gerbils exhibit myogenic regulation but with important differences. Whereas in male gerbils, both spiral modiolar arteries and radiating arterioles exhibited pressure-dependent tone, in females, only radiating arterioles had this property. Male spiral modiolar arteries responded more to L-NNA than female spiral modiolar arteries, suggesting that NO-dependent mechanisms play a bigger role in the myogenic regulation of male than female gerbil cochlear vessels.

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“…BP showed marked increases on administration of NA or NPY. Several reports have suggested that the changes in CBF depend on changes in BP (13,14) and so in this study the normalized value of the CBF was examined, which has been reported to be a useful parameter for evaluating changes in CBF (15). The normalized CBF increased soon after infusion of NPY, and then decreased rapidly to below the baseline level.…”

Section: Discussionmentioning

confidence: 99%

Effects of Neuropeptide Y on Cochlear Blood Flow in Guinea Pigs

Itou

Ogawa²,

Inoue³

et al. 2001

Acta Oto-Laryngologica

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The aim of this study was to clarify the effects of neuropeptide Y (NPY) on cochlear blood flow (CBF) in pigmented guinea pigs. NPY was administered with or without noradrenaline (NA) by systemic perfusion or perilymphatic local perfusion, and CBF was measured using a laser Doppler flowmeter. The systemic and perilymphatic administrations of NPY with NA induced greater prolongation of the increase in and recovery of CBF than the administration of NA or NPY alone. Continuous reduction in CBF induced by NPY may play an important role in the pathogenesis of stress-induced sensorineural hearing losses, such as sudden deafness.

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Autoregulation of cochlear blood flow

Cited by 29 publications

References 11 publications

Systemic Hypotension and the Development of Acute Sensorineural Hearing Loss in Young Healthy Subjects

Systemic Hypotension and the Development of Acute Sensorineural Hearing Loss in Young Healthy Subjects

Gender Differences in Myogenic Regulation along the Vascular Tree of the Gerbil Cochlea

Effects of Neuropeptide Y on Cochlear Blood Flow in Guinea Pigs

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