Autoregulation of RCO by Low-Affinity Binding Modulates Cytokinin Action and Shapes Leaf Diversity

Hajheidari, Mohsen; Wang, Yi; Bhatia, Neha; Vuolo, Francesco; Franco-Zorrilla, José Manuel; Karády, Michal; Mentink, Remco A.; Wu, Anhui; Oluwatobi, Bello Rilwan; Müller, Bruno; Ioio, Raffaele Dello; Laurent, Stefan; Ljung, Karin; Huijser, Peter; Gan, Xiangchao; Tsiantis, Miltos

doi:10.1016/j.cub.2019.10.040

Cited by 31 publications

(17 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first is our assumption of selection for increased binding affinity. Low-affinity binding sites are also commonly employed to regulate gene expression, particularly for the auto-regulation of high-copy number transcription factors in bacteria [61] and during the development of multicellular organisms [44,45,62]. The second assumption is that of a linear relationship between the selective advantage conferred by a mutation and the change in binding affinity that the mutation causes.…”

Section: Discussionmentioning

confidence: 99%

Mutation bias interacts with composition bias to influence adaptive evolution

Cano

Payne

2020

PLoS Comput Biol

View full text Add to dashboard Cite

Mutation is a biased stochastic process, with some types of mutations occurring more frequently than others. Previous work has used synthetic genotype-phenotype landscapes to study how such mutation bias affects adaptive evolution. Here, we consider 746 empirical genotype-phenotype landscapes, each of which describes the binding affinity of target DNA sequences to a transcription factor, to study the influence of mutation bias on adaptive evolution of increased binding affinity. By using empirical genotype-phenotype landscapes, we need to make only few assumptions about landscape topography and about the DNA sequences that each landscape contains. The latter is particularly important because the set of sequences that a landscape contains determines the types of mutations that can occur along a mutational path to an adaptive peak. That is, landscapes can exhibit a composition bias-a statistical enrichment of a particular type of mutation relative to a null expectation, throughout an entire landscape or along particular mutational paths-that is independent of any bias in the mutation process. Our results reveal the way in which composition bias interacts with biases in the mutation process under different population genetic conditions, and how such interaction impacts fundamental properties of adaptive evolution, such as its predictability, as well as the evolution of genetic diversity and mutational robustness.

show abstract

Section: Discussionmentioning

confidence: 99%

Mutation bias interacts with composition bias to influence adaptive evolution

Cano

Payne

2020

PLoS Comput Biol

View full text Add to dashboard Cite

show abstract

“…STM promotes the growth of leaf primordia and thus the emergence of leaflets, while RCO inhibits growth at the base of a developing leaflet, thereby accentuating the growth differences created by marginal patterning (Kierzkowski et al, 2019). Like STM, RCO regulates growth through its orchestration of CK homeostasis (Hajheidari et al, 2019; Hudson, 2019). Modulating both local and global growth by co‐expressing RCO and STM in the A. thaliana leaf is sufficient to convert a simple, serrate A. thaliana leaf into a compound C. hirsuta leaf, demonstrating the impact of growth and patterning on the diversity of leaf shape (Kierzkowski et al, 2019; Satterlee and Scanlon, 2019b).…”

Section: The Development Of the Compound Leafmentioning

confidence: 99%

From genes to networks: The genetic control of leaf development

Wang

Kong

Zhou

2021

JIPB

View full text Add to dashboard Cite

Substantial diversity exists for both the size and shape of the leaf, the main photosynthetic organ of flowering plants. The two major forms of leaf are simple leaves, in which the leaf blade is undivided, and compound leaves, which comprise several leaflets. Leaves form at the shoot apical meristem from a group of undifferentiated cells, which first establish polarity, then grow and differentiate. Each of these processes is controlled by a combination of transcriptional regulators, microRNAs and phytohormones. The present review documents recent advances in our understanding of how these various factors modulate the development of both simple leaves (focusing mainly on the model plant Arabidopsis thaliana) and compound leaves (focusing mainly on the model legume species Medicago truncatula).

show abstract

“…Secondly, RCO leads to growth differences created by the inhibition of marginal patterning [163]. RCO also coordinates the homeostasis of the phytohormone CK through CK biosynthesis and catabolism and their coordinates are essential for complex leaf development in C. hirsuta [164,165]. However, whether the morphological plasticity in C. grandiflora is achieved by the RCO/CK module is still unknown.…”

Section: Molecular Mechanisms Of Heterophylly-a Representative Of Leamentioning

confidence: 99%

Mechanisms of the Morphological Plasticity Induced by Phytohormones and the Environment in Plants

Zhao

et al. 2021

IJMS

View full text Add to dashboard Cite

Plants adapt to environmental changes by regulating their development and growth. As an important interface between plants and their environment, leaf morphogenesis varies between species, populations, or even shows plasticity within individuals. Leaf growth is dependent on many environmental factors, such as light, temperature, and submergence. Phytohormones play key functions in leaf development and can act as molecular regulatory elements in response to environmental signals. In this review, we discuss the current knowledge on the effects of different environmental factors and phytohormone pathways on morphological plasticity and intend to summarize the advances in leaf development. In addition, we detail the molecular mechanisms of heterophylly, the representative of leaf plasticity, providing novel insights into phytohormones and the environmental adaptation in plants.

show abstract

Autoregulation of RCO by Low-Affinity Binding Modulates Cytokinin Action and Shapes Leaf Diversity

Cited by 31 publications

References 54 publications

Mutation bias interacts with composition bias to influence adaptive evolution

Mutation bias interacts with composition bias to influence adaptive evolution

From genes to networks: The genetic control of leaf development

Mechanisms of the Morphological Plasticity Induced by Phytohormones and the Environment in Plants

Contact Info

Product

Resources

About