1999
DOI: 10.1016/s0303-7207(99)00178-1
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Autoregulation of the rat prolactin gene in lactotrophs

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Cited by 20 publications
(12 citation statements)
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“…In transfection assays, PRL inhibits PRL gene transcription, an effect mediated by intermediate and long forms of the PRL receptor (72). PRLdeficient mice develop earlier lactotroph hyperplasia and adenomas that are larger and more invasive than the hyperplasia seen in D2R-deficient mice (73,74), proving the importance of this short autoregulatory loop.…”
Section: Endocrine-specific Mechanisms: Hormone-regulatory Pathwaysmentioning
confidence: 99%
“…In transfection assays, PRL inhibits PRL gene transcription, an effect mediated by intermediate and long forms of the PRL receptor (72). PRLdeficient mice develop earlier lactotroph hyperplasia and adenomas that are larger and more invasive than the hyperplasia seen in D2R-deficient mice (73,74), proving the importance of this short autoregulatory loop.…”
Section: Endocrine-specific Mechanisms: Hormone-regulatory Pathwaysmentioning
confidence: 99%
“…Although LHR expression in lactotrophs is still unclear in mammals, GHR and PRLR have been previously shown to express at the lactotroph level, e.g., GHR in human lactotrophs (Mertani et al, 1995) and PRLR in rat lactotrophs (Morel et al, 1994). In rat pituitary cells or lactotroph cells (e.g, GH3 cells), PRL treatment is known to suppress PRL secretion (Bentley and Wallis, 1987) and gene transcription (Devost and Boutin, 1999). Although the PRL responses caused by PRL induction can vary with the sex of the animal or forms of PRL used (e.g., phosphorylated vs non-phosphorylated PRL) (Johnson et al, 2003), local inhibition on PRL synthesis and secretion by PRL is believed to form an "extra-short loop" for PRL feedback at the pituitary level, e.g., in rodents (Ben-Jonathan et al, 2008;Fitzgerald and Dinan, 2008).…”
Section: Discussionmentioning
confidence: 99%
“…This idea is supported by the findings that (i) PRLR expression was located in pituitary lactotrophs (e.g., rat, Morel et al, 1994), and (ii) PRL treatment could suppress PRL secretion in pituitary cells (e.g., rat, Bentley and Wallis, 1987) and lactotroph cell lines (e.g., GH3 cells, Melmed et al, 1980). Unlike the inhibitory effect on PRL release, no consensus has been reached for the autocrine actions of PRL on PRL synthesis, as no effect (Melmed et al, 1980) and inhibition on PRL production/gene expression (Devost and Boutin, 1999) have been reported. To date, the local actions of other pituitary hormones, e.g., GH and luteinizing hormone (LH), on PRL secretion/gene expression are still unclear.…”
Section: Introductionmentioning
confidence: 99%
“…Prolactin receptors are expressed by anterior pituitary cells [68,69,70,71]; therefore, one of the primary target cells PRL meets once it is secreted are lactotropes [72]. Prolactin receptor signaling inhibits PRL synthesis at the transcriptional level in lactotrope cells, which involves specific pituitary transcription factors [73]. Also, inhibition of its own secretion [72,74] and increased PRLR internalization [75,76] are two other mechanisms by which PRL modulates its production, and consequently its actions at the pituitary level.…”
Section: Prolactin Actions In the Pituitarymentioning
confidence: 99%
“…However, the direct effects of PRL in anterior pituitary cells, especially lactotropes, are usually difficult to assess unequivocally since the stimulus (i.e. PRL) is intrinsically present in the system [73]. Although pituitary PRL can be controlled with dopamine analogs, the latter intrinsically affect apoptosis and proliferation in these cells [60], therefore a dopamine-independent model was needed to address such questions.…”
Section: Prolactin Actions In the Pituitarymentioning
confidence: 99%