Autoschizis: a novel cell death

Jamison, James M.; Gilloteaux, Jacques; Taper, Henryk; Calderón, Pedro Buc; Summers, Jack L.

doi:10.1016/s0006-2952(02)00904-8

Cited by 78 publications

(69 citation statements)

References 42 publications

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“…In previous studies (Gilloteaux et al, 1995(Gilloteaux et al, , 1998a(Gilloteaux et al, , 1998b(Gilloteaux et al, , 2001a(Gilloteaux et al, , 2001b(Gilloteaux et al, , 2001c(Gilloteaux et al, , 2003a(Gilloteaux et al, , 2003bJamison et al, 1996Jamison et al, , 2002Venugopal et al, 1996aVenugopal et al, , 1996bErvin et al, 1998), we reported a new type of cell death induced by oxidative stress that differs from apoptosis and necrosis. During the death process, the cancer cells loose cytoplasm by self-morsellation or self-excision.…”

Section: Cytotoxicity Of Vc:vk 3 Combinationsupporting

confidence: 48%

“…cells showed ultrastructural aspects consistent with autoschizic cell death (Gilloteaux et al, 1998a(Gilloteaux et al, , 1998b(Gilloteaux et al, , 2001a(Gilloteaux et al, , 2001b(Gilloteaux et al, , 2001cJamison et al, 2002Jamison et al, , 2004. The most common motif of autoschizis entails the formation of "doublets" (Ervin et al, 1998).…”

Section: Sham-or Control-treated Cells Sham-treated T24mentioning

confidence: 99%

“…VC exhibits selective toxicity toward melanoma (Bram et al, 1980), leukemia (Park et al, 1980), neuroblastoma (Prasad et al, 1979b), and ascite (Liotti et al, 1984) cell lines by inhibiting cancer cell growth in vitro (Benade et al, 1969;Yamafuji et al, 1971;Koch and Biaglow, 1978;De Loecker et al, 1993;Leung et al, 1993;Medina et al, 1994;Gilloteaux et al, 1995Gilloteaux et al, , 1998aGilloteaux et al, , 1998bGilloteaux et al, , 2001aGilloteaux et al, , 2001bGilloteaux et al, , 2001cGilloteaux et al, , 2003aGilloteaux et al, , 2003bGilloteaux et al, , 2004Gilloteaux et al, , 2005Jamison et al, 1996Jamison et al, , 2002Jamison et al, , 2004Jamison et al, , 2005Menon et al, 1998). VC is selectively toxic to tumor cells in vivo (Pierson and Meadows, 1983;Varga and Airoldi, 1983;Tsao et al, 1988;Taper et al, 2001) and can kill cells in solid primary tumors and metastases (Taper et al, 1987(Taper et al, , 1996Taper and Roberfroid, 1992).…”

Section: Cytotoxicity Of Ascorbatementioning

confidence: 99%

“…The single-electron reduction of the quinone produces the semiquinone that reduces oxygen to the superoxide radical and regenerates the quinone. As a result, redox cycling can ensue and produce large amounts of superoxide, which can dismutate to form H 2 O 2 or form more toxic ROS via intracellular metal-catalyzed reactions (O'Brien, 1991;Venugopal et al, 1996aVenugopal et al, , 1996bJamison et al, 2001Jamison et al, , 2002Jamison et al, , 2004. This redox cycling generates oxidative stress (Bellomo et al, 1982;Cohen and Slubberfield, 1990) and results in a number of deleterious effects on T24 cells, including depletion of NADPH (Akman et al, 1985) and reduced glutathione (Carbonera and Azzone, 1988;Bellomo et al, 1990;Cohen and Stubberfield, 1990;Fawthrop et al, 1991) with the oxidation of sulfhydryl groups in proteins, especially microtubules and other cytoskeletal proteins, such as the cytokeratins (Bellomo et al, 1990;Malorni et al, 1991;Wu et al, 1993aWu et al, , 1993bJarabak and Jarabak, 1995).…”

Section: Menadione Cytotoxicitymentioning

confidence: 99%

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Morphology and DNA degeneration during autoschizic cell death in bladder carcinoma T24 cells induced by ascorbate and menadione treatment

Gilloteaux¹,

Jamison²,

Arnold³

et al. 2005

Anat. Rec.

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Feulgen and actin-phalloidin staining as well as gel electrophoresis have been employed in conjunction with cell ultrastructure to describe the effects of 1-, 2-, and 4-hr ascorbate (VC), menadione (VK 3 ), and ascorbate:menadione (VC:VK 3 ) treatments on the T24 human bladder carcinoma cell line. T24 cells exposed to VC alone display blebs and other superficial membrane defects related to membrane alterations and to superficial cytoskeleton changes. VK 3 treatment damages the cell nucleus and organelles, leads to the redistribution of the organelles in the perikaryon as a consequence of cytoskeletal damage, and results in cytoplasmic self-excisions. After VC:VK 3 treatment, the cells show exaggerated alterations characteristic of each vitamin treatment alone, including damaged mitochondria, self-excision of organelle-free pieces of cytoplasm, and extrusion of the perikaryon containing a nucleus surrounded by the damaged organelles. The nuclear envelope appears intact and contains chromatin that decondenses and dissipates. During the cellular demise that concludes with apparent karyolysis, the cells significantly decrease their size and alter their shape. However, the cisterns of rough endoplasmic reticulum are undamaged, but may become dilated. Since the cellular phenomena leading to cell death differ morphologically from apoptosis and necrosis, but entail selfcutting without nuclear bodies, this new form of cell death was called autoschizis. In addition, gel electrophoresis and Feulgen staining demonstrate that autoschizis is accompanied by random DNA degeneration.

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Section: Cytotoxicity Of Vc:vk 3 Combinationsupporting

confidence: 48%

Section: Sham-or Control-treated Cells Sham-treated T24mentioning

confidence: 99%

Section: Cytotoxicity Of Ascorbatementioning

confidence: 99%

Section: Menadione Cytotoxicitymentioning

confidence: 99%

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Morphology and DNA degeneration during autoschizic cell death in bladder carcinoma T24 cells induced by ascorbate and menadione treatment

Gilloteaux¹,

Jamison²,

Arnold³

et al. 2005

Anat. Rec.

Self Cite

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“…21 Vitamin C is commonly used as an antioxidant but here serves as a prooxidant. Vitamin K3, menadione, is a synthetic provitamin with electroactive naphthoquinone structure as for other K vitamins but with no side chain.…”

Section: Vitamins C and E Interactions-inmentioning

confidence: 99%

Critical Review—Electrochemical Properties of 13 Vitamins: A Critical Review and Assessment

Lovander

Lyon

Parr

et al. 2018

J. Electrochem. Soc.

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Review of the literature on the currently recognized, thirteen vitamins yields an overview of the electrochemical properties that include estimates of the formal potentials at physiological pH and identification of the general classes of redox mechanisms. All vitamins are electroactive and map a range of formal potentials E 0 over a 3 V window. The vitamins are grouped as lipid soluble (vitamins A, D, E, and K) and water soluble (B vitamins and vitamin C). Mechanisms are grouped as single electron transfer agents (B3, B7, B2, C, and D), vitamins that can be both oxidized and reduced (B1, B5, B6, B9, and E), and vitamins that undergo two successive, distinct reductions (B12 and K). Vitamin A voltammetry is uniquely complex. Plot of the formal potentials on a potential axis allows assessment of mechanistic paths to vitamin recycling, antioxidant behavior, pH dependence, electrochemical stability in air, acid, and water, electrochemical instability of vitamin pairs, and cooperative interactions between vitamins in medicine. The potential axis is shown as an effective tool for mapping thermodynamically complex interactions. By modern standards, the US federal government identifies 13 vitamins.3 The water soluble vitamins are vitamin C and the eight B vitamins (B1, B2, B3, B5, B6, B7, B9, B12). The lipid or fat soluble vitamins are A, D, E, and K. The fat soluble vitamins can accumulate in the body whereas the water soluble vitamins do not. There are no current vitamins designated beyond E except for K because materials historically assigned the interposed letter designations either no longer fall under the modern definition of vitamin or several related materials were reclassified. Several vitamins exist in different but related chemical structures.Questions considered in this perspective include whether all vitamins are electroactive; what is the redox potential of the vitamins; what are the kinetics and mechanisms of vitamins on oxidation and reduction; when are vitamins antioxidants; are vitamins stable to water and oxygen; do vitamins interact cooperatively. Although papers are available on the electrochemistry and voltammetry of individual vitamins, no single resource summarizes the electrochemical data for all vitamins. This review compiles and critically assesses the available literature on vitamin voltammetry. The compiled data serve to develop perspective on the electrochemical properties of vitamins and the role of vitamins individually and collectively as electroactive species. This CRES 3 T review assimilates fundamentals of thermodynamics and estimated formal potentials, kinetics, and mechanisms as assessed voltammetrically for individual vitamins to provide perspective on the collective electrochemical properties of the thirteen vitamins. Perspective on vitamin electrochemical properties may contribute to assess yet more complex bioelectrochemical processes. * Electrochemical Society Student Member.* * Electrochemical Society Fellow. z E-mail: johna-leddy@uiowa.eduThe review contains two main sections....

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Nutraceuticals

Scanlan¹

2011

Complementary Medicine for Veterinary Technicians and Nurses

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Autoschizis: a novel cell death

Cited by 78 publications

References 42 publications

Morphology and DNA degeneration during autoschizic cell death in bladder carcinoma T24 cells induced by ascorbate and menadione treatment

Morphology and DNA degeneration during autoschizic cell death in bladder carcinoma T24 cells induced by ascorbate and menadione treatment

Critical Review—Electrochemical Properties of 13 Vitamins: A Critical Review and Assessment

Nutraceuticals

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