Autosomal recessive tubular aggregate myopathy in an Indian family

Pandit, Lekha; Gayathri, Narayanappa; Bhat, Irruvathur Gopalakrishna; Thomas, V.W.

doi:10.1016/j.ejpn.2008.06.008

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…Recently, it has been reported that ROS elicit autophagy, 21,22 and that autophagy, in turn, serves to reduce oxidative damage. [23][24][25] Therefore, the effects of FA-M-β-CyD on ROS production in KB cells (FR-α (+)) were examined ( Figure 4). As shown in Figure 4A and B, FA-M-β-CyD, but not M-β-CyD, significantly enhanced ROS production in KB cells (FR-α (+)).…”

Section: Kameyama Et Almentioning

confidence: 99%

Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin

Kameyama¹,

Motoyama²,

Tanaka³

et al. 2017

IJN

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Mitophagy is the specific autophagic elimination system of mitochondria, which regulates cellular survival via the removal of damaged mitochondria. Recently, we revealed that folate-appended methyl-β-cyclodextrin (FA-M-β-CyD) provides selective antitumor activity in folate receptor-α (FR-α)-expressing cells by the induction of autophagy. In this study, to gain insight into the detailed mechanism of this antitumor activity, we focused on the induction of mitophagy by the treatment of FR-α-expressing tumor cells with FA-M-β-CyD. In contrast to methyl-β-cyclodextrin, FA-M-β-CyD entered KB cells, human epithelial cells from a fatal cervical carcinoma (FR-α (+)) through FR-α-mediated endocytosis. The transmembrane potential of isolated mitochondria after treatment with FA-M-β-CyD was significantly elevated. In addition, FA-M-β-CyD lowered adenosine triphosphate (ATP) production and promoted reactive oxygen species production in KB cells (FR-α (+)). Importantly, FA-M-β-CyD enhanced light chain 3 (LC3) conversion (LC3-I to LC3-II) in KB cells (FR-α (+)) and induced PTEN-induced putative kinase 1 (PINK1) protein expression, which is involved in the induction of mitophagy. Furthermore, FA-M-β-CyD had potent antitumor activity in BALB/c nu/nu mice xenografted with KB cells (FR-α (+)) without any significant side effects. Taken together, these findings demonstrate that the autophagic cell death elicited by FA-M-β-CyD could be associated with mitophagy induced by an impaired mitochondrial function.

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Section: Kameyama Et Almentioning

confidence: 99%

Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin

Kameyama¹,

Motoyama²,

Tanaka³

et al. 2017

IJN

View full text Add to dashboard Cite

show abstract

Autosomal recessive tubular aggregate myopathy in an Indian family

Cited by 1 publication

References 8 publications

Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin

Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin

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Autosomal recessive tubular aggregate myopathy in an Indian family

Cited by 1 publication

References 8 publications

Induction of mitophagy-mediated antitumor activity with folate-appended methyl-&beta;-cyclodextrin

Induction of mitophagy-mediated antitumor activity with folate-appended methyl-&beta;-cyclodextrin

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Product

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Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin

Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin