Autotransfusion in Otolaryngology

Herzon, Fred S.

doi:10.1001/archotol.1978.00790100062015

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…Accurate preoperative estimates of blood product requirements are es¬ sential and decrease the waste of blood products. 4. The use of autologous blood is safe and simple, but requires foresight by the surgeon, and the presence of a blood bank prepared to store autolo¬ gous blood.…”

Section: Commentmentioning

confidence: 99%

Blood Use in Head and Neck Tumor Surgery: Potential for Autologous Blood

McCulloch

Glenn

Riley

et al. 1989

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\Recent increased concern regarding the risks of homologous blood transfusion led us to examine the use of blood products for head and neck tumor surgery. Major head and neck surgical procedures at three University of Washington (Seattle)\p=n-\ affiliated hospitals during 1987 were reviewed. Seventy-seven patients were identified. Parameters studied included the following: tumor site and stage, prior treatment, surgical procedure, preoperative and postoperative hematocrit values, estimated blood loss, operative and postoperative blood product use, and operative time. Data were grouped by procedure. Maxillectomy/midface procedures showed the highest average estimated blood loss (1037 mL) and the highest average blood use (1.5 units), followed by composite resections (883 mL and 0.8 units) and laryngectomies (724 mL and 0.9 units). When the data were subgrouped, larynogopharyngectomy (1450 mL and 4.0 units) and composite resection with mandibular swing (1300 mL and 1.0 units) showed the highest blood loss and blood product use. In the assessable groups, previous administration of radiation did not make a significant difference in blood loss or procedure time. However, blood loss correlated well with procedure time in all groups. The great majority of patients met all requirements to function as blood donors (84%). Sixty-five percent of patients met all criteria and used less than 2 units of blood, making autologous blood a reasonable option for the majority of patients with head and neck tumors.

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Section: Commentmentioning

confidence: 99%

Blood Use in Head and Neck Tumor Surgery: Potential for Autologous Blood

McCulloch

Glenn

Riley

et al. 1989

Archives of Otolaryngology - Head and Neck Surgery

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Intraoperative Blood Salvage: Medical Controversies

Dzik

Sherburne

1990

Transfusion Medicine Reviews

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The effect of storage on the metastatic potential of tumor cells collected in autologous blood

Lane

1989

Transfusion

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Malignancy in a potential autologous blood donor is considered by some as a relative contraindication for the collection of autologous blood. There is, however little experimental information regarding the safety of transfusion of autologous blood that may contain viable tumor cells. The purpose of this study was to determine if tumor cells seeded into autologous blood retain their metastatic potential and, if so, for how long. A well-established model of the pulmonary metastasis of B16/F10 (F10) melanoma in C57BL/6 mice was used. Equal numbers of F10 cells were seeded into CPDA-1 blood from the mice or into saline, and the number of lung tumors was evaluated 14 days after infusion of blood or saline. The CPDA-1 blood seeded with F10 cells was stored for up to 21 days in transfer packs at 4 to 6 degrees C, and the metastatic potential of F10 cells in the stored blood was ascertained as above. F10 cells seeded into autologous blood that was then transfused without storage gave rise to the same number of metastatic foci (404 +/- 32 metastases) as did those cells transfused in saline (374 +/- 38, p = 0.5). In contrast, the number of metastatic foci resulting from the transfusion of blood containing F10 cells decreased progressively after storage of the blood (7 days = 124 +/- 14 metastases; 14 days = 7 +/- 1; 21 days = 2 +/- 1; all p values less than 0.001 vs fresh blood). Also, the predilection of F10 cells to metastasize to the lung was unchanged by storage in blood.(ABSTRACT TRUNCATED AT 250 WORDS)

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Autotransfusion in Otolaryngology

Cited by 4 publications

References 5 publications

Blood Use in Head and Neck Tumor Surgery: Potential for Autologous Blood

Blood Use in Head and Neck Tumor Surgery: Potential for Autologous Blood

Intraoperative Blood Salvage: Medical Controversies

The effect of storage on the metastatic potential of tumor cells collected in autologous blood

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