Auxiliary diagnostic potential of ventricle geometry and late gadolinium enhancement in left ventricular non-compaction; non-randomized case control study

Boban, Marko; Peša, Vladimir; Gabrić, Ivo Darko; Manola, Šime; Peršić, Viktor; Antic-Kauzlaric, Helena; Žulj, Marinko; Včev, Aleksandar

doi:10.1186/s12872-017-0721-0

Cited by 11 publications

(9 citation statements)

References 32 publications

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“…The most common combination of DCM and LVNC was found in 70% of overlapping cases, similar to a previous report [ 26 ]. Although this report found no connections of coexisting trabeculations that fit within NC/C ratio criteria in DCM with clinical points, it only could be partially compared to the present study and our previous study due to using triple criteria of thinning of the compact myocardium, NC/C ratio, and sufficient share of non-compact myocardium in total mass of the left ventricle [ 27 ]. The second most common combination, DCM/HCM, was found in nearly one-third of our overlapping patients, but this combination could be even more powerfully connected with undesirable prognosis due to partially shared gene basics [ 28 , 29 ].…”

Section: Discussioncontrasting

confidence: 58%

Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies

et al. 2018

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BackgroundDilatation and other infrastructural rearrangements of the left ventricle are connected with poor prognosis. The aim of our study was to analyze the overlapping phenotypes and dilatation of the ventricle on impairment of systolic function and existence of late gadolinium enhancement (LGE).Material/MethodsConsecutive sample of cases with dilated left ventricle due to non-ischemic cardiomyopathy and healthy controls were included from our cardiac magnetic resonance imaging (CMR) database for a period of 3 years (n=1551 exams).ResultsThe study included 127 patients; 30 (23.6%) with dilated cardiomyopathy (DCM); 30 (23.6%) with left ventricular non-compaction (LVNC); 13 (10.2%) with hypertrophic cardiomyopathy (HCM), and 50 (39.4%) controls. Overlapping phenotypes were found in 48 (37.8%) of the studied cases. Odds for impairment of systolic function in connection with overlapping phenotypes were estimated at 7.8 (95%-CI: 3.4–17.6), (p<0.001). There were significant differences in geometric parameters for patients with overlapping phenotypes vs. controls, as follows: left ventricle end-diastolic dimension(LVEDD)=6.6±0.8 vs. 5.6±1.0 cm (p<0.001); left ventricular ejection fraction (LVEF)=39.3±14.0 vs. 52.1±16.1 (p<0.001); and existence of LGE 36 (75.0%) vs. 21 (26.6%), (p<0.001), respectively. Overlapping phenotypes correlated with LVEDD (Spearman’s-Rho-CC)=0.521, p<0.001; LVEF (Rho-CC)=−0.447, p<0.001 and LGE (Rho-CC)=0.472, p<0.001.ConclusionsThis study found there are many patients with overlapping phenotypes among NICMPs with dilated left ventricles. Overlapping phenotype was associated with greater LVEDD, lesser systolic function, and commonly existing LGE, which all impose increased cardiovascular risk. Linear midventricular LGE stripe was the most powerfully connected with loss of systolic function.

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Section: Discussioncontrasting

confidence: 58%

Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies

et al. 2018

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“…For the cine imaging analysis, left ventricular structure and function parameters were measured on the short and long axis at the end-diastole and end-systole phases, respectively. The left ventricular geometric parameters included the ratio of noncompacted to compacted myocardium, the maximum/minimum end-diastolic ratio (MaxMin EDDR), LV longitudinal shortening (L-shorten), the two-dimensional sphericity index (2D SI) and the three-dimensional sphericity index (3D SI) 11 – 13 . The specific method is shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

The mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction

Zou

et al. 2021

Sci Rep

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This study evaluated the effects of mitral regurgitation (MR) on cardiac structure and function in left ventricular noncompaction (LVNC) patients. The clinical and cardiovascular magnetic resonance (CMR) data for 182 patients with noncompaction or hypertrabeculation from three institutes were retrospectively included. We analyzed the difference in left ventricular geometry, cardiac function between LVNC patients with and without MR. The results showed that patients with MR had a worse New York Heart Association (NYHA) class and a higher incidence of arrhythmia (P < 0.05). MR occurred in 48.2% of LVNC patients. Compared to LVNC patients without MR, the two-dimensional sphericity index, maximum/minimum end-diastolic ratio and longitudinal shortening in LVNC patients with MR were lower (P < 0.05), and the peak longitudinal strain (PLS) of the global and segmental myocardium were obviously reduced (P < 0.05). No significant difference was found in strain in LVNC patients with different degree of MR; end diastolic volume, end systolic volume, and global PLS were statistically associated with MR and NYHA class (P < 0.05), but the non-compacted to compacted myocardium ratio had no significant correlation with them. In conclusion, the presence of MR is common in LVNC patients. LVNC patients with MR feature more severe morphological and functional changes. Hypertrabeculation is not an important factor affecting structure and function at the heart failure stage.

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“…Other studies proposed a cutoff of 20% of trabecular proportion of the entire LV myocardial mass [ 283 ] or a 35% proportion of non-compacted volume of 35% of the LV volume [ 284 ]. LGE was not found to be a strong diagnostic marker [ 285 ] although a recent meta-analysis found that patients with LVNC but without LGE have a better prognosis than those with LGE. When LGE is negative and global systolic function is preserved, no hard cardiac events are to be expected [ 286 ].…”

Section: Myocarditis and Other Cardiomyopathiesmentioning

confidence: 99%

SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance

Leiner

Bogaert

Friedrich

et al. 2020

Journal of Cardiovascular Magnetic Resonance

224

110

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The Society for Cardiovascular Magnetic Resonance (SCMR) last published its comprehensive expert panel report of clinical indications for CMR in 2004. This new Consensus Panel report brings those indications up to date for 2020 and includes the very substantial increase in scanning techniques, clinical applicability and adoption of CMR worldwide. We have used a nearly identical grading system for indications as in 2004 to ensure comparability with the previous report but have added the presence of randomized controlled trials as evidence for level 1 indications. In addition to the text, tables of the consensus indication levels are included for rapid assimilation and illustrative figures of some key techniques are provided.

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Auxiliary diagnostic potential of ventricle geometry and late gadolinium enhancement in left ventricular non-compaction; non-randomized case control study

Cited by 11 publications

References 32 publications

Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies

Overlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies

The mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction

SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance

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