1998
DOI: 10.1097/00007890-199808270-00012
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Auxiliary Partial Orthotopic Liver Transplantation From Living Donors

Abstract: Functional competition may occur in APOLT with preservation of the portal blood flow to the native liver, whereas preemptive transection of the native liver portal vein is a safe procedure and effectively prevents the portal steal phenomenon.

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Cited by 51 publications
(54 citation statements)
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“…Functional competition between the NL and the auxiliary graft has been emphasized in several clinical studies [2, 4,5,16,20,21]. These studies mainly focus on the influence of underlying liver disease and graft rejection [2, 4, 51.…”
Section: Discussionmentioning
confidence: 99%
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“…Functional competition between the NL and the auxiliary graft has been emphasized in several clinical studies [2, 4,5,16,20,21]. These studies mainly focus on the influence of underlying liver disease and graft rejection [2, 4, 51.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, in the only two clinical series of ALT for FHF, poor portal blood flow is not mentioned as a possible cause of non-regeneration of the NL [2,5]. In ALT for chronic liver disease, some authors suggest that interruption of portal flow to the NL may ensure good graft function, but this is contradictory to the long-term aim of ALT for FHF [21]. Experimentally, in a rat model of ALT, preservation of the portal flow to the NL and perfusion of the graft by the caval flow is not a good option, since this technique results in graft atrophy within 2 weeks [22].…”
Section: Discussionmentioning
confidence: 99%
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“…There has been several reports of long-term graft atrophy following APOLT in metabolic disorders. 5 This is thought to be due to portal insufficiency in long term, due to preferential flow into the native liver. Yabe et al 5 have gone to the extent of completely ligating the native liver portal vein to divert portal flow to the graft.…”
Section: Augmenting Optimal Portal Blood Flow To the Graftmentioning
confidence: 99%
“…5 This is thought to be due to portal insufficiency in long term, due to preferential flow into the native liver. Yabe et al 5 have gone to the extent of completely ligating the native liver portal vein to divert portal flow to the graft. This we believe defeats the whole purpose of APOLT and the possible gene therapy in the future.…”
Section: Augmenting Optimal Portal Blood Flow To the Graftmentioning
confidence: 99%