Auxiliary partial orthotopic liver transplantation: treatment of acute liver failure in a new rat model

Palmes, Daniel; Dietl, Karl-Heinz; Drews, Gerald; Hölzen, Jens Peter; Herbst, Hermann; Spiegel, H. U.

doi:10.1007/s00423-001-0263-9

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…7 In 2002, Palmes published the APOLT technique in the rat with a survival rate of 70-80 %, the animals were sacrificed after two weeks. 19 In this model the left lobe of the graft was transplanted after resection of the left lobe of the native liver. The graft's portal vein was anastomosed endto-end to the left segmental portal vein of the recipient, thus resulting in surgical difficulty to perform the operation, since the lumen of the vessels becomes very small.…”

Section: Representative Resultsmentioning

confidence: 99%

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Schleimer

Kalder

Grommes

et al. 2014

JoVE

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In acute hepatic failure auxiliary liver transplantation is an interesting alternative approach. The aim is to provide a temporary support until the failing native liver has regenerated.1-3 The APOLT-method, the orthotopic implantation of auxiliary segments-averts most of the technical problems. However this method necessitates extensive resections of both the native liver and the graft. A liver graft reduced to 30 % of its original size, was heterotopically implanted in the right renal region of the recipient after explantation of the right kidney. The infra-hepatic caval vein of the graft was anastomosed with the infrahepatic caval vein of the recipient. The arterialization of the donor's portal vein was carried out via the recipient's right renal artery with the stent technique. The blood-flow regulation of the arterialized portal vein was achieved with the use of a stent with an internal diameter of 0.3 mm. The celiac trunk of the graft was end-to-side anastomosed with the recipient's aorta and the bile duct was implanted into the duodenum. A subtotal resection of the native liver was performed to induce acute hepatic failure. 7In this manner 112 transplantations were performed. The perioperative survival rate was 90% and the 6-week survival rate was 80%. Six weeks after operation, the native liver regenerated, showing an increase in weight from 2.3±0.8 g to 9.8±1 g. At this time, the graft's weight decreased from 3.3±0.8 g to 2.3±0.8 g.We were able to obtain promising long-term results in terms of graft morphology and function. HALT with flow-regulated PVA reliably bridges acute hepatic failure until the native liver regenerates. Video LinkThe video component of this article can be found at

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Section: Representative Resultsmentioning

confidence: 99%

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Schleimer

Kalder

Grommes

et al. 2014

JoVE

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Bedeutung der Transplantatrearterialisierung nach auxiliärer partieller orthotoper Lebertransplantation (APOLT) in der Therapie des akuten Leberversagens

Palmes

Dietl

Budny

et al. 2002

Chirurgisches Forum 2002

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Impact of graft rearterialization after auxiliary partial orthotopic liver transplantation in the treatment of acute liver failure

Palmes

Dietl

Drews

et al. 2002

Transplantation Proceedings

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Auxiliary partial orthotopic liver transplantation: treatment of acute liver failure in a new rat model

Abstract: This new rat model simulates the clinical features of an ALF treated by APOLT and is especially interesting for further basic research on the interaction between native liver and auxiliary graft after APOLT.

Cited by 4 publications

References 23 publications

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Bedeutung der Transplantatrearterialisierung nach auxiliärer partieller orthotoper Lebertransplantation (APOLT) in der Therapie des akuten Leberversagens

Impact of graft rearterialization after auxiliary partial orthotopic liver transplantation in the treatment of acute liver failure

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