Auxological and endocrinological features in internationally adopted children

Stagi, Stefano; Papacciuoli, Valeria; Boiro, Djibril; Maggioli, Chiara; Ndambao, Niane Ndeye; Losi, Stefania; Chiappini, Elena; Toni, Sonia; Ndiaye, O

doi:10.1186/s13052-020-00832-5

Cited by 12 publications

(10 citation statements)

References 67 publications

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“…The closure of schools, the sudden disruption of extended social and family relationships, the change in daily habits and parental anxiety about financial and other problems may have affected children’s emotional stability and sense of security [ 33 ]. As yet there is little data on how children in all countries responded psychologically to the crisis but [ 34 ] the importance of psychological factors in precocious puberty has been reported in children migrating from developing to developed countries, primarily through international adoption [ 35 ]. It has been hypothesised that for adopted children who move from a deprived environment to a resource rich environment, environmental factors which slow or delay pubertal development are deactivated while factors which favour pubertal development are enhanced, triggering the onset of puberty [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…As yet there is little data on how children in all countries responded psychologically to the crisis but [ 34 ] the importance of psychological factors in precocious puberty has been reported in children migrating from developing to developed countries, primarily through international adoption [ 35 ]. It has been hypothesised that for adopted children who move from a deprived environment to a resource rich environment, environmental factors which slow or delay pubertal development are deactivated while factors which favour pubertal development are enhanced, triggering the onset of puberty [ 35 ]. Genetic factors cannot fully explain the high incidence of precocious puberty in internationally adopted girls as their average menarcheal age is lower than the average menarcheal age both in their foster countries and in their countries of origin [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has been hypothesised that for adopted children who move from a deprived environment to a resource rich environment, environmental factors which slow or delay pubertal development are deactivated while factors which favour pubertal development are enhanced, triggering the onset of puberty [ 35 ]. Genetic factors cannot fully explain the high incidence of precocious puberty in internationally adopted girls as their average menarcheal age is lower than the average menarcheal age both in their foster countries and in their countries of origin [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

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Increased incidence of precocious and accelerated puberty in females during and after the Italian lockdown for the coronavirus 2019 (COVID-19) pandemic

et al. 2020

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Background The timing of puberty in girls is occurring at an increasingly early age. While a positive family history is recognised as a predisposing factor for early or precocious puberty, the role of environmental factors is not fully understood. Aims of the study To make a retrospective evaluation of the incidence of newly diagnosed central precocious puberty (CPP) and the rate of pubertal progression in previously diagnosed patients during and after the Italian lockdown for COVID-19, comparing data with corresponding data from the previous 5 years. To determine whether body mass index (BMI) and the use of electronic devices increased during lockdown in these patients. Patients and methods The study included 49 females with CPP. We divided the patients into two groups: group 1, patients presenting a newly diagnosed CPP and group 2, patients with previously diagnosed slow progression CPP whose pubertal progression accelerated during or after lockdown. We collected auxological, clinical, endocrinological and radiological data which were compared with data from two corresponding control groups (patients followed by our Unit, March to July 2015–2019). Patients’ families completed a questionnaire to assess differences in the use of electronic devices before and during lockdown. Results Thirty-seven patients presented newly diagnosed CPP (group 1) and 12, with previously diagnosed but untreated slow progression CPP presented an acceleration in the rate of pubertal progression (group 2). The number of new CPP diagnoses was significantly higher than the mean for the same period of the previous 5 years (p < 0.0005). There were no significant differences between patients in group 1 and control group 1 regarding time between appearance of B2 and CPP diagnosis, although group 1 patients had a significantly earlier chronological age at B2, a more advanced Tanner stage at diagnosis (p < 0.005), higher basal LH and E2 levels, higher LH peak after LHRH test (p < 0.05) and increased uterine length (p < 0.005) and ovarian volume (p < 0.0005). The number of patients with previously diagnosed CPP whose pubertal development accelerated was also statistically higher compared to controls (p < 0.0005). In this group, patients’ basal LH (p < 0.05) and E2 levels (p < 0.0005) became more markedly elevated as did the LH peak after LHRH test (p < 0.05). These patients also showed a significantly accelerated progression rate as measured by the Tanner scale (p < 0.0005), uterine length (p < 0.005), and ovarian volume (p < 0.0005). In both group 1 and group 2, BMI increased significantly (p < 0.05) and patients’ families reported an increased use of electronic devices (p < 0.0005). Conclusion Our data show an increased incidence of newly diagnosed CPP and a faster rate of pubertal progression in patients with a previous diagnosis, during and after lockdown compared to previous years. We hypothesize that triggering environmental factors, such as the BMI and the use of electronic devices, were enhanced during lockdown, stressing their possible role in triggering/influencing puberty and its progression. However, more studies are needed to determine which factors were involved and how they interacted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Increased incidence of precocious and accelerated puberty in females during and after the Italian lockdown for the coronavirus 2019 (COVID-19) pandemic

et al. 2020

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“…Closures of schools reduced physical activity, expanded sedantary activities and cause the increase of childhood obesity. Recent studies revealed that changes in lifestyles associated with COVID-19 lockdown caused the increase of obesity prevalence among children and adolescents [9,10].…”

Section: Covid-19 Pandemic and Pubertymentioning

confidence: 99%

“…The effects of psychological stress on the development of puberty are not clearly known. Stagi et al [9] reported the importance of psychological factors in precocious puberty in children migrating from developing to developed countries.…”

Section: Covid-19 Pandemic and Pubertymentioning

confidence: 99%

Effects of COVID-19 pandemic on pediatric endocrinology practice; childhood obesity, pubertal progression and diabetes

Sağsak¹,

Aycan²

2022

Pamukkale Medical Journal

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In the COVID-19 pandemic, millions of people have had to stay in isolation for months.Children did not go to school for a long time, they spent much more time at home and were sedentary. They also spent much more time on screen-related activities (personal computer (PC), mobile phone, music player, tablet, game console, and television (TV)).These situations have had various effects on children and adolescents. Undoubtedly, longterm restrictions and lifestyle changes have had effects on individuals with childhood obesity, pubertal progression, and type 1 diabetes (T1D). In this review, articles investigating the effect of COVID-19 quarantine/pandemic on adolescence, childhood obesity and diabetes were compiled and the effect of the COVID pandemic on these frequently encountered situations in pediatric endocrine practice was tried to be revealed.

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Understanding and Expanding the Role of Pediatricians in Child Adoption in the Backdrop of Emerging Regulations in India: A Contemporary Review

Bharti,

Malhi

2024

Indian Pediatr

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Auxological and endocrinological features in internationally adopted children

Cited by 12 publications

References 67 publications

Increased incidence of precocious and accelerated puberty in females during and after the Italian lockdown for the coronavirus 2019 (COVID-19) pandemic

Increased incidence of precocious and accelerated puberty in females during and after the Italian lockdown for the coronavirus 2019 (COVID-19) pandemic

Effects of COVID-19 pandemic on pediatric endocrinology practice; childhood obesity, pubertal progression and diabetes

Understanding and Expanding the Role of Pediatricians in Child Adoption in the Backdrop of Emerging Regulations in India: A Contemporary Review

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