Avaliação da buprenorfina pelas vias intravenosa ou intramuscular em cães anestesiados pelo desfluorano

Souza, Almir Pereira de; Nishimori, Celina Tie; Santos, Paulo Sérgio Patto dos; Paula, Danielli Parrilha de; Nunes, Newton; Rezende, Marlis L.; Henao-Guerrero, Piedad Natalia

doi:10.1590/s0103-84782004000300024

Cited by 4 publications

(5 citation statements)

References 11 publications

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“…A depressão respiratória, passível de ocorrer em algumas situações, pode ser revertida com o uso de antagonistas opióides, como o naloxone (THURMON et al, 1996). Quanto a via de administração, a buprenorfina pode vir a ser utilizada pelas vias intravenosa (IV) ou intramuscular (IM), pois as variações clínicas observadas são consideradas mínimas (SOUZA et al, 2004).…”

Section: Introductionunclassified

Efeitos cardiorrespiratórios da buprenorfina em cães anestesiados pelo desfluorano

et al. 2005

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Objetivou-se, com este estudo, avaliar os efeitos da buprenorfina sobre variáveis cardiovasculares e respiratórias em cães durante anestesia com desfluorano. Para tanto, foram utilizados 20 cães adultos, distribuídos em dois grupos (GB e GC). A anestesia foi induzida com propofol (8mg kg-1 IV) e em seguida os animais foram intubados com sonda de Magill, a qual foi conectada ao aparelho de anestesia para administração de desfluorano (1,5 CAM). Após 30 minutos, foi aplicado no GB buprenorfina (0,02mg kg-1) e no GC solução de NaCl à 0,9% (0,05ml kg-1). Avaliaram-se: freqüências cardíaca e respiratória (FC e <FONT FACE=Symbol>¦</FONT>); pressões arteriais sistólica, diastólica e média (PAS, PAD e PAM); débito cardíaco (DC); pressão venosa central (PVC); e as variáveis hemogasométricas pH, PaCO2, PaO2, HCO3, SatO2 e DB. As colheitas dos dados foram feitas aos 30 minutos após o início da administração do desfluorano (MO), 15 minutos após a administração do opióide ou placebo (M15), e a cada 15 minutos após Ml5 (M30, M45, M60 e M75). A avaliação estatística dos dados foi efetuada por meio de Análise de Perfil (P<0,05). Houve discreta redução da FC no GB, enquanto as outras variáveis cardiovasculares não tiveram redução significativa. A <FONT FACE=Symbol>¦</FONT> e o pH tiveram reduções no GB, enquanto a PaCO2 esteve aumentada. Concluiu-se que a inclusão da buprenorfina durante anestesia inalatória pelo desfluorano determina discretas alterações cardiovasculares, bem-como potencializa a hipoventilação promovida pelo desfluorano, com a manifestação de hipercapnia, o que não contra-indica o seu uso em pacientes estáveis.

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Efeitos cardiorrespiratórios da buprenorfina em cães anestesiados pelo desfluorano

et al. 2005

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“…The phenotiazínics have been recommended as antiarrhythmogenic producers 18 41, 42 , however, in this work, an atrioventricular block (AVB) occurred when the intravenous continuous infusion was undertaken but at a lower level by the change of xylazine for medetomidine. Soon after anesthetic premedication, a slight reduction in systolic arterial pressure (SAP), medial arterial pressure (MAP) and diastolic arterial pressure (DAP) was obtained in both groups, assumed as buprenorphine effects following the intravenous or intramuscular injection in dogs 43,44, besides a slight hypotension 24 . Nevertheless, all the values remained within the physiological limits, 100 to 160 mmHg, 80 to 120 mmHg and 60 to 100 mmHg, respectively, in both groups, at all moments.…”

Section: Resultsmentioning

confidence: 99%

Continuous infusion in adult females dogs submitted to ovariohysterectomy with midazolam-xylazine and/or medetomidine pre-treated with methotrimeprazine and buprenorphine

et al. 2007

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PURPOSE: To compare, by continuous infusion of ketamine or medetomidine combined to methotrimeprazine and buprenorphine, ketamine and midazolam, the degree of hypnosis, myorelaxation, anesthetic quality and surgical feasibility through evaluation of possible parametric alterations and recovery quality. METHODS: 20 healthy adult females dogs, aged 3 to 5 years, body weight between 7 and 15 kg, were assigned randomly and homogenously to 2 groups of 10 animals each (n=10), group 1 (G1) and group 2 (G2), respectively. Animals of G1 were subjected to a pre-treatment with intravenous 1.0 mg/kg methotrimeprazine and or 3ì/kg. After 15 minutes, a 5.0 mg/kg ketamine and 0.2 mg/kg midazolam were intravenously injected. Immediately after induction, an anesthetic combination of 0.4 mg/kg/h midazolam, 20 mg/kg/h ketamine and 1.0 mg/kg/h xylazine, was continuously and intravenously administered for 30 minutes. The same techniques were used in G2 except for the substitution of xylazine for 30ìg/kg/h medetomidine. RESULTS: In G1 there was a 1st and 2nd degree atrioventricular heart block, a longer recovery period and lower quality. In G2 a 1st degree atrioventricular heart block occurred but isolated and ephemeral. CONCLUSIONS: The continuous infusion method, besides reducing drugs utilization, prevented collateral effects allowing a more tranquil recovery with no excitations, both protocols permitted the surgical procedure (ovary-hysterectomy) bringing about a reduction in hypnosis and an accentuated myorelaxation. Xylazine and medetomidine showed a similar pharmacodynamic behavior but with different clinical aspects. The electrocardiographic alterations observed in G2 and in a lower degree in G1 must be well studied. Describers: dogs, ketamine, methotrimeprazine, medetomidine, midazolam and xylazine.

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“…The jugular vein was then isolated and catheterized with a Swan-Ganz catheter (Cateter Swan-Ganz Pediátrico, mod. 132-5f, 4 vias Edwards Lifesciences LLC, Irvine, CA, EUA), whose end was positioned inside the lumen of the pulmonary artery; this was confirmed by observation of pressure waves, according to the technique described by Swan-Ganz and cited by Souza et al (2004). The inner side of the left thigh was shaved for transcutaneous catheterization of the femoral artery where a pressure transducer was connected and attached to a multiparameter monitor to measure blood pressure.…”

Section: Introductionmentioning

confidence: 99%

“…For measurement of the cardiac output (CO), necessary for calculation of the cardiac index [CO divided by body surface area (BSA) in m 2 ], we used a microprocessor device for direct measurement of CO through the thermodilution technique (SOUZA et al, 2004). The Average Blood Pressure was measured by direct reading, in mmHg, using a multi-parameter monitor whose transducer was connected to the catheter inserted in the left femoral artery and positioned at the heart level as "zero reference" for calibration.…”

Section: Introductionmentioning

confidence: 99%

Effects of nitrous oxide on cardiovascular parameters in pigs anesthetized with propofol and subjected to pressure-controlled ventilation

Carneiro

Lopes

Gering

et al. 2017

SCA

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This paper evaluated the effects of the ratio of nitrous oxide to oxygen (50% of each) on cardiovascular parameters in pigs anesthetized with propofol and maintained in ventilation with intermittent positive pressure. Sixteen Large White pigs, weighing between 15 and 20 kg, were divided into two groups of eight animals, and designated as follows: GPN (propofol/nitrous oxide) and GPA (propofol/compressed air). In order to allow endotracheal intubation, the animals received azaperone (2 mg kg -1 , IM) followed, after 20 minutes, by intravenous propofol. After successful intubation, continuous infusion of propofol was initiated at a dose of 0.4 mg kg -1 minute -1 . From this point, the GPN group received N 2 O (diluted in 50% oxygen), while the GPA group received compressed air (diluted in 50% oxygen). Rocuronium was then administered by continuous intravenous infusion at 0.6 mg kg -1 h -1 . Pressurecontrolled ventilation (PCV) was started and adjusted to 15 cmH 2 O, and the respiratory rate was set to reach capnometry readings between 35-45 mmHg. The measurement of parameters (heart rate, mean arterial pressure, cardiac index, systemic vascular resistance index, stroke index) begun 15 minutes after the administration of rocuronium, and was repeated in 15-minute intervals for 60 minutes. Data were statistically analyzed by ANOVA followed by Bonferroni test. The results showed that the 1:1 ratio combination of nitrous oxide to oxygen (50% each) did not alter the mentioned parameters in pigs anesthetized with propofol and maintained at pressure-controlled ventilation, indicating that it is a safe protocol for the cardiovascular system.

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Avaliação da buprenorfina pelas vias intravenosa ou intramuscular em cães anestesiados pelo desfluorano

Cited by 4 publications

References 11 publications

Efeitos cardiorrespiratórios da buprenorfina em cães anestesiados pelo desfluorano

Efeitos cardiorrespiratórios da buprenorfina em cães anestesiados pelo desfluorano

Continuous infusion in adult females dogs submitted to ovariohysterectomy with midazolam-xylazine and/or medetomidine pre-treated with methotrimeprazine and buprenorphine

Effects of nitrous oxide on cardiovascular parameters in pigs anesthetized with propofol and subjected to pressure-controlled ventilation

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