Avaliação da eficácia e segurança do extrato de folhas de Rubus rosaefolius Sm. visando a aplicação como conservante em produtos cosméticos

Ostrosky, Elissa Arantes

doi:10.11606/t.9.2009.tde-28092009-105736

Cited by 1 publication

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References 23 publications

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“…Many studies are being carried out to find plant species with potential antifungal activity Höfling et al, 2010), because synthetic drugs may exhibit high toxicity to patients (Araújo et al, 2004). Substances more efficient against pathogenic microorganisms and less toxic to the patient could be isolated from vegetal species (Ostrosky, 2009). Studies performed by Ogundare et al (2006) demonstrated that bark extracts from Vernonia tenoreana inhibited the growth of Candida albicans.…”

Section: Introductionmentioning

confidence: 99%

Vernonanthura polyanthes leaves aqueous extract enhances doxorubicin genotoxicity in somatic cells of Drosophila melanogaster and presents no antifungal activity against Candida spp.

et al. 2016

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Vernonanthura polyanthes (Spreng.) A.J. Vega & Dematt. (Asteraceae), known as "assa-peixe", has been used in ethnomedicine for the treatment of various diseases such as bronchitis, pneumonia, hemoptysis, persistent cough, internal abscesses, gastric and kidney stone pain. Moreover, some studies demonstrated that species of Genus Vernonia present antifungal activity. Due to the biological relevance of this species, the aim of this study was to investigate the toxic, genotoxic, antigenotoxic and antifungal potential of V. polyanthes leaves aqueous extract in somatic cells of Drosophila melanogaster or against Candida spp. The aqueous extract of the plant showed no toxic, genotoxic and antigenotoxic activity in the experimental conditions tested using the wing somatic mutation and recombination test (SMART/wing). However, when the extract was associated with doxorubicin, used in this work as a positive control, the mutagenic potential of doxorubicin was enhanced, increasing the number of mutations in D. melanogaster somatic cells. In the other hand, no inhibitory activity against Candida spp. was observed for V. polyanthes leaves aqueous extract using agar-well diffusion assay. More studies are necessary to reveal the components present in the V. polyanthes leaves aqueous extract that could contribute to potentiate the doxorubicin genotoxicity.Keywords: assa-peixe, Asteraceae, Cerrado, SMART/wing test, Vernonia polyanthes.O extrato aquoso das folhas de Vernonanthura polyanthes potencializa a genotoxicidade da doxorrubicina em células somáticas de Drosophila melanogaster e não apresenta atividade antifúngica contra Candida spp. ResumoVernonanthura polyanthes (Spreng.) A.J. Vega & Dematt. (Asteraceae), conhecida como "assa-peixe", tem sido utilizada na medicina popular para o tratamento de várias doenças, como bronquite, pneumonia, hemoptise, tosse persistente, abcessos internos, afecções gástricas e cálculo renal. Além disso, alguns estudos já demonstraram que espécies do Gênero Vernonia apresentam atividade antifúngica. Devido à relevância biológica dessa espécie, o objetivo deste estudo foi investigar os efeitos citotóxico, genotóxico, antigenotóxico e antifúngico do extrato aquoso das folhas de V. polyanthes em células somáticas de Drosophila melanogaster ou contra Candida spp. O extrato aquoso da planta não apresentou atividade citotóxica, genotóxica e antigenotóxica nas condições experimentais testadas usando o teste de recombinação e mutação somática em asa (SMART-asa). No entanto, quando o extrato foi associado com a doxorrubicina, utilizada neste trabalho como controle positivo, o potencial mutagênico da doxorrubicina foi potencializado, aumentando oBraz.

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Section: Introductionmentioning

confidence: 99%