2001
DOI: 10.1590/s1676-24442001000400004
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Avaliação da tolerância à vancomicina em 395 cepas hospitalares de Staphylococcus aureus resistentes à oxacilina

Abstract: ou = 32. Do total de cepas estudadas, 10,4% apresentaram CIM de 0,5µg/ml para vancomicina; 41,3%, CIM de 1µg/ml; 42,2%, CIM de 2µg/ml; e 6,1%, CIM de 4µg/ml. Em média, 49,1% dos Orsa apresentaram tolerância à vancomicina. Em conclusão, a tolerância à vancomicina entre as cepas Orsa foi considerada elevada. Conseqüentemente, aumentam as chances de falhas no tratamento com vancomicina, além de aumentar o risco da emergência de Staphylococcus aureus vancomicina-intermediário.]]>

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Cited by 13 publications
(14 citation statements)
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“…However, considering the CPS isolated from ants, we found greater resistance among the strains isolated from the campus, including resistance to vancomycin of exclusive hospital use, the last effective form of treatment of serious infections caused by methycillin-resistant S. aureus (Mendoza et al 2000, Oliveira et al 2001, Goldrick 2002, Marin 2002. The two strains presenting resistance to this antibiotic were collected from two individuals of T. melanocephalum (numbers 20 and 24), but this level of resistance was not found in strains isolated from the respective environments, which reinforces the importance of this species as a major bacterial vector.…”
Section: Resultsmentioning
confidence: 94%
“…However, considering the CPS isolated from ants, we found greater resistance among the strains isolated from the campus, including resistance to vancomycin of exclusive hospital use, the last effective form of treatment of serious infections caused by methycillin-resistant S. aureus (Mendoza et al 2000, Oliveira et al 2001, Goldrick 2002, Marin 2002. The two strains presenting resistance to this antibiotic were collected from two individuals of T. melanocephalum (numbers 20 and 24), but this level of resistance was not found in strains isolated from the respective environments, which reinforces the importance of this species as a major bacterial vector.…”
Section: Resultsmentioning
confidence: 94%
“…Tolerance to vancomycin in S. aureus is related to therapeutic failures in defined clinical circumstances, especially in septicemia, endocarditis, osteomyelitis, meningitis and in immunodepressed patients [16]. Both tolerance as well as resistance to vancomycin are considered unstable and introduced phenomena, and they appear during the treatment with the drug [17]. Researches that are meant to investigate colonization by S. aureus in health staff do not report lineages sensitivity to vancomycin.…”
Section: Discussionmentioning
confidence: 99%
“…O S. aureus contém ainda, na estrutura de sua parede celular, polissacarídeos e proteínas antigê-nicas, bem como outras moléculas importantes, as quais podem induzir uma resposta imunológica no hospedeiro. Entre essas outras moléculas podemos citar o ácido tecói-co, o glicanopeptídio, a proteína A, além da presença de cápsula e de adesinas (Tabela 1) (20,29) . O alto potencial infeccioso do S. aureus não está restrito apenas à sua facilidade de multiplicação e disseminação nos tecidos, mas também à produção de moléculas com grande poder patogênico, que incluem enzimas e toxinas (Tabela 2).…”
Section: Mecanismos De Patogenicidadeunclassified
“…Outro indicativo foi o aparecimento, em hospitais dos EUA, de cepas de Enterococcus resistentes à vancomicina (VRE) isoladas de materiais clínicos (24,39,42) . Em 1997 foi descrito, pelo Professor Keich Hiramatsu, da Universidade de Jutendo, Japão, um caso de uma cepa MRSA resistente à vancomicina isolada de uma ferida cirúrgica de um garoto de 4 meses (29,42,44) . Em 2000 foram encontradas, no Brasil, as primeiras cepas de S. aureus com resistência à vancomicina em um hospital de referência do município de Queimados, no Rio de Janeiro.…”
Section: Tabelaunclassified