Avaliação da toxicidade das favas de Stryphnodendron fissuratum (Mimosoideae) em vacas gestantes

Aguiar-Filho, Cristiano R; Albuquerque, Raquel F.; Rocha, Brena P.; Colodel, Edson M.; Lemos, Ricardo A.A.; Riet-Correa, Franklin; Evêncio-Neto, Joaquim; Mendonça, Fábio de Souza

doi:10.1590/s0100-736x2013000500010

Cited by 9 publications

(12 citation statements)

References 19 publications

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“…Liver lesions have been described in ruminants after intake of mashed beans from Stryphnodendron fissuratum (Ferreira et al 2009, Aguiar-Filho 2013. Fonseca & Linbradi (2008) reported that possible toxicity of tannins in dye prepared with bark of Stryphnodendron barbatiman occurred in mammalian cells.…”

Section: Resultsmentioning

confidence: 99%

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Acute and chronic toxicity and antimicrobial activity of the extract of Stryphnodendron adstringens (Mart.) Coville

et al. 2017

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MG 39404-547, Brazil. E-mail: aca2006@ica.ufmg.br This study evaluated the antimicrobial activity and acute or chronic toxicity of the extract of Stryphnodendron adstringens. The stem bark dry extract was obtained by static maceration with ethanol. Quantification of tannins was performed by the Folin-Denis method, which indicated a total tannin content of 32.7%. The antimicrobial activity of the dry extract of S. adstringens was evaluated by agar-based disk diffusion assay with Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923) in the concentration of 200, 400 and 600μL/mL. The results indicated that 600μL/mL inhibited microbial growth, i.e. had antimicrobial activity against these species. Acute and chronic toxic effects of S. adstringens was evaluated in Wistar rats treated with 200, 400, 600 and 800mg/kg of extract, administrated by gavage. Liver degeneration was observed in the group of rats receiving 800mg/kg in chronic exposure, what may indicate some degree of toxicity at this concentration. However, no systemic toxicity was observed at lower doses. Considering the broad use of S. adstringens as a phytotherapeutic agent for various human and animal diseases and the livertoxicity observed at high concentrations, attention should be paid to the possible adverse effect of using the extract from this plant at high concentration.

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Section: Resultsmentioning

confidence: 99%

“…Macáková et al (2014) and Okuda & Ito (2011) described a wide pharmacological spectrum of activity of polyphenols including hydrolysable tannins. However, Ferreira et al (2009) and Aguiar-Filho (2013) reported intoxication of ruminants with plants that have tannins.…”

Section: Introductionmentioning

confidence: 99%

Acute and chronic toxicity and antimicrobial activity of the extract of Stryphnodendron adstringens (Mart.) Coville

et al. 2017

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“…Amostras de sangue total para obtenção de soro foram colhidas dos bovinos na fase aguda -que foram os três animais necropsiados -e de três animais em fase de recuperação. Avaliou-se aspartato amino--transferase (AST), γ-glutamiltransferase (GGT), ureia e creatinina utilizando-se kits comerciais (Roche Cobas C11) 1 . Amostras da planta foram enviadas para o setor de botânica da UFMS para identificação.…”

Section: Surto Espontâneounclassified

“…Antes do início dos experimentos, os bezerros foram submetidos à avaliação clínica, pesagem, desverminação e coleta de sangue venoso através de punção na veia jugular para realização de hemograma e mensuração dos níveis séricos de γ-glutamiltransferase (GGT), aspartato aminotransferase (AST), ureia e creatinina utilizando kits comerciais (Roche Cobas C111) 1 . Coleta de sangue e dosagem das enzimas continuaram sendo realizadas diariamente após o início do experimento.…”

Section: Intoxicação Experimentalunclassified

Photosensitization in Cattle Caused by Spontaneous and Experimentally Ingestion of Stryphnodendron fissuratum

Lazaro

Bacha

Pupin³

et al. 2018

Acta Scientiae. Vet.

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Background: Stryphnodendron fissuratum is a tree from the Brazilian Cerrado. Its fruit is toxic to cattle and can cause clinical digestive signs, hepatogenous photosensitization, and abortion. Cases of poisoning in cattle, goats and guinea pigs have been experimentally reproduced; however, photosensitization could not be reproduced. The aim of this work was to describe an outbreak of natural poisoning and experimental reproduction in cattle, both with hepatogenous photosensitization.Materials, Methods & Results: Its described and natural outbreak and an experimental poisoning. In the outbreak, three bovines in the acute phase and three in the chronic phase were examined. Blood samples were collected from all of these animals in order to measure serum levels of aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), urea, and creatinine. The first three animals underwent necropsy and histopathological evaluation. The experiment was conducted with two nine-month-old calves that received an oral paste made with crushed S. fissuratum fruits mixed with water. These fruits were collected at a farm at which cattle poisoning cases had occurred. Blood samples were collected in order to measure serum levels of AST, GGT, urea, and creatinine, before plant administration and then daily during the experimental period. Skin biopsies were taken before plant administration and new one after the first signs of skin lesions. The natural outbreak affected 52 of 160 bovine (31 calves and 21 cows) in the lot. Two calves and 14 cows died. Clinical signs consisted of depression, ataxia, incoordination, behavioral changes, decubitus, and death. One animal that died and 36 others that recovered had photodermatitis. Necropsy findings in the animals consisted of bad corporal condition, pale kidneys, evidence of liver lobular pattern, dry rumen contents, and full bladder. In two animals, fruit seeds were found in the rumen, and one animal had ulcers and transmural edema in the abomasum. Microscopically, mild to moderate renal tubular distension, accumulation of proteinaceous material in lumen with mild to moderate swelling, and epithelial necrosis. In the liver, swelling of hepatocytes and moderate bile stasis was detected. Enzymes values in all evaluated bovines were higher than those considered normal for the species. Experimentally, both calves became ill and one died. The clinical signs were apathy, inappetence, wobbling, weight loss, and goosebumps. One of them had jaundice, tearing, photophobia, ear skin detachment, and ulcers at the muzzle, nostrils and ventral face of the tongue. This animal was euthanized in extremis, and the necropsy findings showed generalized jaundice, evidence of increased liver lobular pattern, thick bile, pale kidneys, and esophageal, tongue, and epiglottal ulcers. Microscopically, the lesions were similar to those described during the natural outbreak. The skin biopsy from the calf that recovered showed perivascular edema and mild eosinophilia.Discussion: The diagnosis was made based on clinical signs, necropsy findings, histopathological lesions, and epidemiological analysis. Experimentally, the plant was toxic at the administered doses. Photosensitization was the most common clinical sign during the natural outbreak and until now, has never been experimentally reproduced. Based on histopathological lesions observed in this study, we can consider that is from hepatogenous origin. The results showed that the kidney lesions have an important role during the pathogenesis caused by this poisoning and during disease evolution.

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“…Várias plantas são descritas como causadoras de intoxicações em pequenos ruminantes, porém apenas algumas são reconhecidas causando distúrbios reprodutivos, tais como: Ateleia glazioviana (Gava et al 2001), Tetrapterys multiglandulosa (Cardinal et al 2010), Tetrapterys acutifolia (Caldas et al 2011), Stryphnodendron obovatum (Tokarnia et al 1998) e Stryphnodendron fissuratum (Aguiar-Filho et al 2013), Aspidosperma pyrifolium (Sousa et al 2014), Mimosa tenuiflora (Dantas et al 2010, Santos et al 2012) e mais recentemente Poincianella pyramidalis (Santos et al 2014, Reis et al 2016, Câmara et al 2017. Sendo as três últimas descritas como causadoras de problemas reprodutivos na região Nordeste do Brasil.…”

Section: Introductionunclassified

Malformações congênitas e abortos induzidos experimentalmente pela ingestão de Poincianella pyramidalis (Tul.) L.P. Queiroz (catingueira) em ovelhas

et al. 2017

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Poincianella pyramidalis (catingueira) is a toxic plant associated with abortions, embryonic losses and malformations in goats and laboratory animals. Outbreaks and sporadic cases of spontaneous intoxication in sheep have been reported in the last five years in the agreste of Pernambuco. Due to the occurrence of these spontaneous cases and the lack of researches in sheep, an experimental study was carried out to evaluate the teratogenic effects of P. pyramidalis on sheep. In the experiment, 16 female and three male sheeps, mixed breed, were used. Females were divided in four groups, with four animals per group and maintained in individual stalls, underwent estrus synchronization and mating by natural mating and after 30 days the diagnosis was made to confirm gestation. Groups were named group 1 (G1), group 2 (G2), group 3 (G3), and group 4 (G4). In G1 (control) the ewes were fed with 1% of concentrate supplementation (CS) based on live weight (LW) and 2% of maize silage (MS) with a daily intake of 3% dry matter (DM) based on LW. In G2 feeding was constituted of 1% of CS based on LW and 2% of forage, including 2% of roughage, 50% was hay of P. pyramidalis and the other 50% of DM. In G3 feed was constituted of 1% of CS based on LW and 2% of roughage. Among these 2% of roughage, 80% was hay of P. pyramidalis and the other 20% of DM. In G4 the sheep were fed with 1% CS based on the LW and the roughage consisting of 100% P. pyramidalis hay.

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Avaliação da toxicidade das favas de Stryphnodendron fissuratum (Mimosoideae) em vacas gestantes

Cited by 9 publications

References 19 publications

Acute and chronic toxicity and antimicrobial activity of the extract of Stryphnodendron adstringens (Mart.) Coville

Acute and chronic toxicity and antimicrobial activity of the extract of Stryphnodendron adstringens (Mart.) Coville

Photosensitization in Cattle Caused by Spontaneous and Experimentally Ingestion of Stryphnodendron fissuratum

Malformações congênitas e abortos induzidos experimentalmente pela ingestão de Poincianella pyramidalis (Tul.) L.P. Queiroz (catingueira) em ovelhas

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