Avaliação de arboviroses (Dengue, Zika vírus e Chikungunya) em doadores e receptores de transplante de células-tronco hematopoiéticas do HC-FMUSP

Oliveira, Fernando Nivaldo de

doi:10.11606/d.5.2022.tde-18042023-115238

Cited by 1 publication

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the increasing understanding of the molecular events of virus replication has contributed to the emergence of new antiviral drugs, no specific therapy is currently available for WNV infection despite extensive testing 31,32 . In this scenario, studies that seek alternative strategies have become increasingly relevant, considering that the use of a drug with effective antiviral capacity during epidemics can reduce the burden of the disease, especially regarding neurotropic agents 33 .…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Antiviral Activity of Inga Edulis Leaf Extract in Neuroblastoma Cells Infected With West Nile Virus

Wanzeller

Gomes

Júnior

et al. 2023

Preprint

View full text Add to dashboard Cite

The genus Orthoflavivirus integrates several arboviruses of great im- portance in public health, including West Nile virus (WNV). The search for new bioactive compounds of natural origin has become a very important line of research. The species Inga edulis Martius is used in folk medicine as an antidiarrheal and anti-inflammatory agent. In silico analyses were performed to predict the pharmacokinetics and toxicodynamics of the main compounds present in the extract, followed by in vitro analyses. A time-of-addition assay was carried out to evaluate the antiviral effect of the extract at different stages of infection. The results demonstrate the main compounds of the extract did not retain the blood-brain barrier permeability and their bioavailability complied with what is expected for a good drug in some parameters. The CC50 obtained was 144.6 µg/mL, with the highest concentrations used (25 and 50 µg/mL) not significantly cytotoxic to the cells. The concentration of 25 µg/mL showed anti-WNV action when added before or during the infection procedure. It is therefore concluded that the compounds from the crude extract of I. edulis leaves have an inhibitory activity in WNV infection in neuroblastoma cells and can be further explored for the development of antiviral drugs.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigation of the Antiviral Activity of Inga Edulis Leaf Extract in Neuroblastoma Cells Infected With West Nile Virus

Wanzeller

Gomes

Júnior

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Avaliação de arboviroses (Dengue, Zika vírus e Chikungunya) em doadores e receptores de transplante de células-tronco hematopoiéticas do HC-FMUSP

Abstract: Avaliação de arboviroses (Dengue, Zika vírus e Chikungunya) em doadores e receptores de transplante de células-tronco hematopoiéticas do HC-FMUSP

Cited by 1 publication

References 34 publications

Investigation of the Antiviral Activity of Inga Edulis Leaf Extract in Neuroblastoma Cells Infected With West Nile Virus

Investigation of the Antiviral Activity of Inga Edulis Leaf Extract in Neuroblastoma Cells Infected With West Nile Virus

Contact Info

Product

Resources

About