Avaliação do equilíbrio entre oxidantes e antioxidantes na patogénese da doença pulmonar obstrutiva crónica

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is one of the most common chronic diseases and a major cause of morbility and mortality. An imbalance between oxidants and antioxidants (oxidative stress) has been proposed as a critical event in the pathogenesis of COPD. The increased oxidative stress in patients with COPD is the result of exogenous oxidants namely pollutants and cigarette smoke as well as endogenous oxidant production during inflammation. The aim of the present study was to clarify the hypothesis about the presence of an imbalance between oxidants and the antioxidant defences associated to COPD. In this study, we evaluated a biomarker of oxidative stress (malondialdehyde, a lipid peroxidation derived product) and non-enzymatic antioxidants (vitamin C and the sulphydryl groups) in COPD patients and healthy controls. The marker of oxidative stress was found to be significantly (p<0,001) higher in COPD patients when compared with the control group. No age dependent changes in the plasma levels of lipid peroxidation products were found. COPD patients had a significant (p<0,001) decrease in antioxidant status compared with control group. Our results show that oxidative stress is an important pathophysiologic change in COPD.

Oxidant-Antioxidant Balance in the Blood of Patients with Chronic Obstructive Pulmonary Disease After Smoking Cessation

“…Likewise, increased peroxidation of lipids and oxidation of proteins of the erythrocytes and platelets from patients with COPD and asthma were confirmed by de Castro et al [28]. A higher concentration of MDA in the blood plasma of COPD patients, as compared with that found in healthy subjects, was found by Cristóvão et al [29]. Folchini et al [30] observed statistically significant differences between the blood TBARS levels in patients with COPD depending on the gravity of the disease.…”

Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review

“…A significant decrease in non-protein SH groups, mainly in the form of reduced GSH, has been found in many of the examined studies [28, 34, 40, 41, 43, 45, 53] (Table 1). No differences have been found considering only mild COPD [55] (Table 1).…”

“…A decreased level of vitamin C [25, 28, 62] and E [25, 28, 30], as well as no difference in the levels of vitamin A [27], C [40, 48, 95] and E [27] has been described in COPD compared to healthy controls. No differences have also been found in the different stages of severity of disease [96].…”

Modelling c-Abl Signalling in Activated Neutrophils: the Anti-inflammatory Effect of Seliciclib

“…If inflammatory cytokines are produced chronically, then c-Abl will remain activated, and primed tissue neutrophils will continue to produce ROS. This appears to be a major contributor to tissue damage resulting from inflammatory disease, including chronic obstructive pulmonary disease (COPD) [7-10]. COPD is the sixth largest cause of death worldwide.…”