Avaliação do impacto causado pela disponibilidade de 17β-estradiol livre ou complexado à β-ciclodextrina no ambiente aquático sobre Oreochromis niloticus (tilápia)

Silva, M.C.G.; Silva, S.C.B.L.; Santos, Thamiris Pinheiro; Soares, Priscila Rafaela Leão; Andrade, André Lucas Corrêa de; Cadena, Marília Ribeiro Sales; Cadena, Pabyton Gonçalves

doi:10.1590/1678-4162-9462

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Complexation with cyclodextrins is one of the most commonly used strategy to increase the solubility, stability and safety of poorly soluble molecules [11]. Thus, the physicochemical characterization of such complexes is of utmost importance in order to prove that complexation has taken place.…”

Section: Discussionmentioning

confidence: 99%

“…Cyclodextrins (CDs) are cyclic oligosaccharides of a variable number of glucose units, linked by α-(1,4) glycosidic bonds. They are characterized by a hydrophobic cavity and a hydrophilic exterior, and for this reason, CDs are able to host hydrophobic molecules in their interior, therefore, forming the so-called inclusion complexes (ICs) [11]. Some drugs are already marketed in Europe, Japan, United States and Brazil as complexes with cyclodextrins, which includes dexamethasone, nimesulide, omeprazole, piroxicam, indomethacin and itraconazole [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity

et al. 2019

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α, β amyrin (ABAM) is a natural mixture of pentacyclic triterpenes that has a wide range of biological activities. ABAM is isolated from the species of the Burseraceae family, in which the species Protium is commonly found in the Amazon region of Brazil. The aim of this work was to develop inclusion complexes (ICs) of ABAM and β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) by physical mixing (PM) and kneading (KN) methods. Interactions between ABAM and the CD’s as well as the formation of ICs were confirmed by physicochemical characterization in the solid state by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetry (TG) and differential scanning calorimetry (DSC). Physicochemical characterization indicated the formation of ICs with both βCD and HPβCD. Such ICs were able to induce changes in the physicochemical properties of ABAM. In addition, the formation of ICs with cyclodextrins showed to be an effective and promising alternative to enhance the anti-inflammatory activity and safety of ABAM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity

et al. 2019

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The complexation of steroid hormones into cyclodextrin alters the toxic effects on the biological parameters of zebrafish (Danio rerio)

Silva

Santos

et al. 2019

Chemosphere

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The objective of this study was to evaluate the toxic effects of progesterone (PF) and estradiol (EF) and the effect of these steroid hormones complexed into cyclodextrins, commercially available drugs, such as micronized progesterone (PM) and transdermal estradiol (ET), and evaluate them as endocrine disruptors through biological parameters of Danio rerio. An acute toxicity test was performed with hormones using D. rerio embryos according to OECD 236 guidelines. The heart rate, mortality, and teratogenic effects were evaluated. In addition, a chronic toxicity test was assayed with adult animals for evaluation of animal behavior, reproductive capacity, and electrophysiological responses of the retina. Analysis of the results of the acute toxicity test with embryos exposed to progestins and estrogens showed that free hormones caused a higher percentage of teratogenic effects such as pericardial edema, yolk sac edema, and spinal deformation. Behavioral evaluation (30-60 days) of adult animals exposed to PM, EF, and ET demonstrated higher frequencies of aggressive behaviors such as Chase away, Persecution, Escape, and Attack. Analysis of reproductive capacity did not show significant differences in the number of viable eggs, and no significant changes were observed in the electrophysiological responses of the retina. According to these results, there is a higher toxicity effect of hormones in the free form when compared to the commercial forms and inclusion complexes. This indicates that complexation into cyclodextrin reduced the toxicity of the hormones according to the parameters studied.

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Avaliação do impacto causado pela disponibilidade de 17β-estradiol livre ou complexado à β-ciclodextrina no ambiente aquático sobre Oreochromis niloticus (tilápia)

Cited by 2 publications

References 17 publications

Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity

Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity

The complexation of steroid hormones into cyclodextrin alters the toxic effects on the biological parameters of zebrafish (Danio rerio)

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