Avaliação Dos Frascos Conta-Gotas De Diferentes Marcas De Diclofenaco Resinato Comercializados No Mercado Brasileiro

Abstract

RESUMOOs antiinflamatórios não-esteróides (AINE's), integram o grupo dos fármacos mais comumente prescritos mundialmente e estão entre os mais utilizados nas práticas de automedicação. Possuem propriedades antiinflamatórias, analgésicas e antipiréticas. Autores afirmam que é importante evitar prescrever em gota, quando se deseja uma dose exata, pois o volume de uma gota varia com a densidade e viscosidade do líquido, e com o orifício do gotejador e o ângulo no qual se goteja. Como os gotejadores utilizados na indústria não são padronizados, este trabalho tem como objetivo avaliar as diferenças de concentração, em miligramas/gota, de 10 diferentes marcas de medicamentos contendo diclofenaco resinato na apresentação de gotas orais (15mg/mL), de acordo com suas bulas e com o número de gotas por mL para cada gotejador, comparando com as doses indicadas pela literatura.Palavras-chave: diclofenaco resinato; gotejadores; dose de medicamento. ABSTRACTNon steroidal anti-inflammatory (NSAID) integrates the group of drugs more commonly prescribed world-wide and also are used in the practical of self-medication. They possess anti-inflammatory, analgesic and antipyretic properties. Authors affirm that it is important to prevent to prescribe drops, when desire an accurate dose, because the volume of a drop varies with the density and viscosity of the liquid, and with the orifice of the bottle dropper and the angle in which it drips. As the bottle droppers used in the industry are not standardized, this work has as objective to evaluate the concentration differences, in milligrams/drop, of 10 different medicine marks of diclofenac resinate in the presentation of oral drops (15mg/mL), in accordance with its drug package inserts and with the number of drops for mL for each bottle dropper, comparing with the doses indicated in the literature.

Dropper Systems: A Short Review of Experimental and CFD Simulation Studies

“…The properties of fluid mixtures play a crucial role in various scientific studies. For instance, a detailed analysis of surface tension and viscosity values of a 50% glycerol-water mixture is provided by Zhang X, et al [12]. This study also suggests using a mixture of water with n-propanol for droplet formation analysis, among other glycerol-water percentage mixtures.…”

“…The case was simulated using the software FLUENT 17.2 and considers the filling of air at the same time as the emptying of the syringe, a phenomenon that should be considered in normal cases, as well as in the The existence of residues on the walls of the dosing instrument is also mentioned Hanson B, et al [4], stating that there is no practical, reliable, and computational approach to modeling a movable interface with these characteristics in a realistic way. This work proposes precisely this approach to analyzing the fluid-structure interaction, and cannot adopt the method of Zhang X, et al [12] in neglecting data such as the viscosity of the solution. A standard model by IDDSI is used by Hanson B, et al [4] and provides the identification of the syringe used experimentally.…”

“…In these cases, the surface tension and fluid viscosity generate pressure at the outlet as each bubble volume manages to break this tension, overcoming it. In the measurements done by Zhang X, et al [12] tension, viscosity and curvature variation of the bubble formed were neglected in comparison to the capillary resistance generated by the tube. The pressure can be calculated considering the repetitive formation of a bubble in the diameter of the nozzle using the Young-Laplace equation, 2…”

Primeiros socorros nas escolas: Uma abordagem interdisciplinar em escolas públicas de Santarém-PA

“…A análise farmacoeconômica objetiva identificar, medir e comparar os custos (recursos consumidos com produtos farmacêuticos, serviços e outros gastos diretos e indiretos de um tratamento) e as consequências (econômicas, clínicas e humanísticas) provenientes de sua utilização. É um instrumento que possibilita selecionar as opções mais eficazes com boa relação custo/benefício (ALCANTARA; VIRTUOSO; MENEGATTI, 2007;MENG, 2008).…”