Avaliação dos níveis de cortisol e glicemia em cães anestesiados pelo sevofluorano, pré-medicados com butorfanol ou meperidina

Abstract

The objective of this study was to compare the influence of butorphanol and phetidine as part of the preanesthetic medication, in 20 healthy dogs submitted to experimental orthopedic surgery. Dogs were randomly allocated in two groups: GI, acepromazine and butorphanol (0,05 mg.kg 1 and 0,4 mg.kg 1 , respectively, i.m.) and, GII, acepromazine and phetidine (0,05 mg.kg 1 and 4 mg.kg 1 , respectively, i.m.). Anesthesia was induced by administration of propofol (5 mg.kg 1 ) and maintained by the use of sevoflurane delivered in a 100% oxygen circuit. Plasma concentrations of cortisol and glucose were measured during several surgical procedures: T0, before preanesthetic medication; T1, 20 minutes after preanesthetic medication; T2, at skin incision; T3, at periostal stimulation; and, T4, at skin suture. Concentrations of plasma glucose were not significantly different between the surgical procedures and between the two groups evaluated. Concentrations of plasma cortisol were significantly higher in dogs administered with butorphanol between the surgical procedures of T0 and T3, compared with values for dogs administered with phetidine. These results suggest that phetidine is more adequate to control plasma cortisol in dogs submitted to orthopedic surgery than anesthesia with sevoflurane. Key words: Anesthesia, opioids, neuroendocrine stress, canine ResumoO objetivo deste estudo foi comparar a influência do butorfanol ou meperidina como medicação pré-anestesica nos níveis de cortisol e glicemia em vinte cães submetidos a cirurgia ortopédica experimental. Os cães foram distribuídos em grupos: GI recebeu acepromazina e butorfanol (0,05 mg.kg 1 e 0,4 mg.kg 1 respectivamente, i.m.) e GII, acepromazina e meperidina (0,05 mg.kg 1 e 4 mg.kg 1 respectivamente, i.m.). A indução anestésica constou de propofol (5 mg.kg 1 ) e para a manutenção sevofluorano em 100% de oxigênio. A concentração plasmátca de cortisol e glicose foram mensuradas no momentos: T0 antes da medicação pré-anestésica; T1 -vinte minutos após a medicação pré-anestésica; T2 -incisão de pele; T3 -estimulação periosteal e T4 -sutura de pele. Não houve diferença entre os momentos e grupos na dosagem de glicose. A concentração plasmatica de cortisol foi significativamente maior nos cães que receberam butorfanol entre T0 e T3, comparado com o grupo que recebeu meperidina. Esses resultados sugerem que a meperidina promove maior controle da dosagem de cortisol em cães submetidos a cirurgia ortopédica e anestesiados com sevofluorano Palavras-chave: Anestesia, opióides, estresse neuroendócrino, caninos

Evaluation of Xylazine Ketamine Anesthesia in Rabbits Undergoing Tendon Surgery: A Prospective Randomized Controlled Study

“…At 120 minutes, the XK group had a rectal temperature of 36.80°C, and the K group recorded a temperature of 37.10°C. This comprehensive data provides a detailed insight into the dynamic physiological responses of rabbits in both groups undergoing tendon surgery and anesthesia, highlighting the changes in heart rate, respiratory rate, and rectal temperature throughout the experimentalDiscussionSurgical procedures are associated with a complex stress response characterized by neurohormonal, immunological, and metabolic alterations which are intimately related to the severity of the lesion, duration of surgery, and the clinical status of the patient[9]. These responses induce a wide range of alterations in diverse organs and systems, which have resulted in various studies aimed at minimizing or inhibiting these alterations.…”