Sodium hypochlorite is an irrigant solution widely used in chemotherapeutic treatment for a long time with great effectiveness. Gluconate chlorhexidine is a newer product but with excellent properties but there is still considerable controversy over which is the best product for the treatment of the canal. This study aims to identify through literature review using articles from 2006 to 1016 the use of sodium hypochlorite versus chlorhexidine gluconate as a solution Irrigator in endodontic treatment. Both gluconate chlorhexidine and sodium hypochlorite have great properties fundamental for endodontic treatment, neither of which can be disregarded. It is only necessary to analyze in detail when to use the hypochlorite or chlorhexidine that can be used alternately in the preparation of the endodontic canal, taking due care not to use them simultaneously because interaction between the two products provide a high toxicity. Hypochlorite may be used to initiate treatment and dissolution of pulp tissue and to terminate chlorhexidine treatment after pre-cleaning the hypochlorite removal canal, taking full advantage of the two products' qualities for best results.