Avaliação “In Vitro” Da Eficácia Do Extrato Hidroalcoólico Do Cajá (Spondias Mombin L.) E Da Graviola (Annona Muricata L.) Sobre Microorganismos Orais / in Vitro Evaluation of the Efficacy of Cajá (Spondias Mombin L.) and Soursop (Annona Muricata L.) Hydroalcoholic Extract on Oral Microorganisms

Freitas, Raphael Fernando Dias de; Canelli, Amanda Pissinatti; Aro, Andréa Aparecida de; Sartoratto, Adilson; Franzini, Cristina Maria; Góes, Vívian Fernandes Furletti de

doi:10.34117/bjdv6n9-204

Cited by 1 publication

(2 citation statements)

References 45 publications

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“…These authors demonstrated that this extract inhibited the growth of C. albicans and C. krusei, when used at The hydroethanolic extracts of the bark and fruits of S. mombin were evaluated for their antifungal potential against oral microorganisms, including C. albicans, Candida dubliniensis and C. tropicalis, demonstrating a fungistatic effect at a concentration of 8000 µg/mL. However, unlike the findings of the present research, no fungicidal effect was observed (De Freitas et al 2020).…”

Section: S Ta P H Y Lo C Oc C U S a U R E U S E S C H E R Ic H Ia C O...contrasting

confidence: 55%

“…A significant number of plant extracts had their antifungal and antibacterial activities demonstrated by previous research (Chaves et al 2018;De Freitas et al 2020;Roumy et al 2020;Samuggam et al 2021). However, this study is the first to report the effectiveness of S. mombin in enhancing the antibacterial activity of conventional antibiotics against resistant bacteria.…”

Section: Introductionmentioning

confidence: 79%

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HPLC–DAD analysis and antimicrobial activities of Spondias mombin L. (Anacardiaceae)

et al. 2022

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Spondias mombin is used in the folk medicine for the treatment of diarrhea and dysentery, indicating that extracts obtained from this species may present pharmacological activities against pathogenic microorganisms. The purpose of this work was to investigate the chemical composition and evaluate the antimicrobial activity of extracts obtained from the leaves (aqueous) and bark (hydroethanolic) of S. mombin both as single treatments and in combination with conventional drugs. Following a qualitative chemical prospection, the extracts were analyzed by HPLC-DAD. The antimicrobial activities were evaluated by microdilution. The combined activity of drugs and extracts was verified by adding a subinhibitory concentration of the extract in the presence of variable drug concentrations. The Minimum Fungicidal Concentration (MFC) was determined by a subculture of the microdilution test, while the effect of the in vitro treatments on morphological transition was analyzed by subculture in moist chambers. While the qualitative analysis detected the presence of phenols and flavonoids, the HPLC analysis identified quercetin, caffeic acid, and catechin as major components in the leaf extract, whereas kaempferol and quercetin were found as major compounds in the bark extract. The extracts showed effective antibacterial activities only against the Gram-negative strains. With regard to the combined activity, the leaf extract potentiated the action of gentamicin and imipenem (against Staphylococcus aureus), while the bark extract potentiated the effect of norfloxacin (against S. aureus), imipenem (against Escherichia coli), and norfloxacin (against Pseudomonas aeruginosa). A more significant antifungal (fungistatic) effect was achieved with the bark extract (even though at high concentrations), which further enhanced the activity of fluconazole. The extracts also inhibited the emission of filaments by Candida albicans and Candida tropicalis. Together, these findings suggest that that the extract constituents may act by favoring the permeability of microbial cells to conventional drugs, as well as by affecting virulence mechanisms in Candida strains.

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Section: S Ta P H Y Lo C Oc C U S a U R E U S E S C H E R Ic H Ia C O...contrasting

confidence: 55%

Section: Introductionmentioning

confidence: 79%