Avanços no uso de células-tronco em ortopedia

Cristante, Alexandre Fogaça; Narazaki, Douglas Kenji

doi:10.1590/s0102-36162011000400003

Cited by 10 publications

(7 citation statements)

References 46 publications

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“…Las CT adultas pueden ser obtenidas a través de medula ósea (MO), sangre periférica, cordón umbilical, hígado fetal, tejido neural u otros diversos tejidos mesenquimales del individuo adulto, tales como sinovia, perióstio, tejido muscular o tejido adiposo (2).…”

Section: Características De Las Células-madre (Ct)unclassified

“…En esas situaciones, la terapia celular con estas células tiene como objetivo potencializar el mecanismo natural de corrección, concentrando las mismas en el local de la lesión para que puedan actuar más eficientemente (1). Con los avances en la medicina, hoy es posible colectar, cultivar y re-infundir las células-madre con finalidad terapéutica, formando diversos tejidos, como óseo, hepático, neural y adiposo (2).…”

Section: Introductionunclassified

“…Under such situations, the cell therapy with those cells aims at enhancing the natural correction mechanism, concentrating them at the injury site so that they can act more effectively (1). With the advances in medicine, nowadays it is now possible to collect, cultivate and REINFUNDIR the stem cells with therapeutic purpose, forming different tissues, such as bone, liver, and neural (2).…”

Section: Introductionmentioning

confidence: 99%

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Células-madre adultas en la cicatrización de fracturas e injertos óseos

S¹,

Lpf

et al. 2018

Rev MVZ Córdoba

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The traumatic accidents which result in fractures and even in impairment of a bone segment have a high prevalence in routine veterinary surgery. Many times these fractures are complex and difficulty healing or need bone grafts to preserve and restore the length of the affected limb. Thus, the recovery time of these animals is usually delicate and long, with complications risks, such as delayed union and non-union of the fractured bone segments or absence of graft incorporation. In this sense, the stem cells (SC) have shown to be a strong ally of the orthopedic doctors due to their capacity to provide osteoprogenitor cells, to increase the osteoinductive effect minimize the healing time and provide a greater efficiency to the repairing process. Due to that, before the expectation of their assignments, this review aims to describe the stem cells characteristics, their current applications in the fractures healing and, especially, their contribution to the bone grafts consolidation.Keywords: Mesenchymal stem cells, bone tissue, cell therapy, bone transplantation (Source: MeSH). RESUMENLos accidentes traumáticos que resultan en fracturas y hasta en el comprometimiento de un segmento óseo tienen alta prevalencia en la rutina quirúrgica veterinaria. Muchas veces esas fracturas son complejas y presentan dificultades de cicatrización o necesitan de injertos óseos para preservar y restaurar el largo del miembro acometido. De esa forma, el tiempo de recuperación de esos animales suele ser delicado y prolongado con riegos de complicaciones, como unión retardada y no unión de los segmentos óseos fracturados o ausencia de incorporación de los injertos. En este sentido, las células-madre (CT) vienen demostrando ser una fuerte aliada de los ortopedistas debido a su capacidad en proveer células osteoprogenitoras, de incrementar el efecto osteoinductor, minimizar el tiempo de cicatrización y proporcionar mayor eficiencia al proceso reparador. Frente a la expectativa de sus atribuciones, la presente revisión tiene por objetivo describir las características de las células-madre, sus aplicaciones actuales en la cicatrización de fracturas y, especialmente, su contribución en la consolidación de injertos óseos.Palabras clave: Células-madre mesenquimales, tejido óseo, terapia celular, trasplante óseo (Fuente: MeSH). Adult stem cells in the healing of fractures and bone graftsCélulas-madre adultas en la cicatrización de fracturas e injertos óseos INTRODUCCIÓNEl principio de la terapia celular consiste en reparar tejidos u órganos dagnificados con la sustitución de las células no funcionales por células normales. Las CT presentes en el organismo, de forma natural, ejercen esa función; sin embargo, cuando las lesiones son más extensas, las CT no son capaces de corregirlas y la enfermedad se establece. En esas situaciones, la terapia celular con estas células tiene como objetivo potencializar el mecanismo natural de corrección, concentrando las mismas en el local de la lesión para que puedan actuar más eficientemente (1). Con los...

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Section: Características De Las Células-madre (Ct)unclassified

Section: Introductionunclassified

Section: Introductionmentioning

confidence: 99%

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Células-madre adultas en la cicatrización de fracturas e injertos óseos

S¹,

Lpf

et al. 2018

Rev MVZ Córdoba

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“…In contrast, recent studies have shown that mesenchymal progenitor cells can repair major defects regardless of age. The great difficulty is still the culture, induction of differentiation, and adhesion at the lesion site, which often do not respond as expected [17].…”

Section: Introductionmentioning

confidence: 99%

“…Traumatic chondral injuries, when moderate and in areas of low mechanical stress, are usually treated by conservative methods that include dietary reduction for weight reduction, analgesics, anti-inflammatories, and physiotherapy. When extensive, more complex treatments are stipulated as autologous or homologous osteochondral grafts, replacement arthroplasty using partial or total prostheses and arthrodesis [17].…”

Section: Introductionmentioning

confidence: 99%

Macroscopic Anatomy, Histopathology, and Image Diagnosis of Joints and Synovial Cartilages

Alves¹,

Rodrigues²,

Silva³

et al. 2018

Cartilage Repair and Regeneration

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Joints are physiological connections formed by the association of two or more bones that confer mobility to the skeleton of vertebrates. Composed of several structures, these are often related to pathologies of varied origins, which determine symptomatology of varying degrees of intensity and impairment, responsible for the decrease in life expectancy and the well-being of affected populations. Most of the time, the treatment for these diseases is only symptomatic, aiming at the relief of pain and the return of the patient to daily activities. Thus, there has been an increasing interest in the search for new knowledge about the mechanisms that lead to joint disorders and effective therapeutic resources that may contribute to the fight against pain and to the definitive treatment of joint dysfunctions. To this aim, the knowledge of diagnostic methods, especially imaging methods, is of fundamental importance for the recognition of articular affections, enabling a targeted and effective treatment. Among these auxiliary exams currently used to evaluate the joints, the noninvasive ones are the first choice, where radiography, ultrasonography, magnetic resonance imaging (MRI), computed tomography, and arthroscopy are inserted.

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