aveExpression of mir-29a-5p, sclerostin and fetuin-A in patients with chronic kidney disease and their correlation with vascular calcification

Ma, Xiaoying; Sheng, Yuping; Yang, Xingmeng; Wang, Na; Zhang, Haoran; Xu, Haiping; Sun, Fuyun

doi:10.14715/cmb/2022.68.7.12

Cited by 2 publications

References 16 publications

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Correlations of plasma angiopoietin-like 7, fetuin-A levels with coronary heart disease in patients with type 2 diabetes mellitus

Xue,

Tian,

et al. 2023

Preprint

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Background: The prevalence of coronary heart disease (CHD) is higher in patients with type 2 diabetic mellitus (T2DM), however, relative parameters for evaluating T2DM patients with CHD are quite limited. Circulating angiopoietin-like 7（Angptl7）, fetuin-A（Fet-A） levels have all been found correlated with CHD and T2DM. Therefore, this study aimed to investigate the correlations of plasma Angptl7 and Fet-A levels with the CHD in patients with T2DM. Methods: T2DM patients were recruited and divided into diabetes without CHD group (T2DM, n=48) and diabetes with CHD group (T2DM+CHD, n=51) according to the history of CHD. Baseline data were collected. Plasma levels of Angptl7 and Fet-A were measured by enzyme-linked immunosorbent assay (ELISA) method. Results: Compared with that in T2DM patients, plasma Angptl7 levels in patients with T2DM+CHD were significantly increased，while the Fet-A levels and vitamin D levels were significantly decreased (P all<0.05). . Age, plasma level of Angptl7 and Fet-A were influence factors of occurrence of CHD in T2DM patients. Angptl7 and Fet-A possessed diagnostic value for T2DM patients with CHD, and the value was even higher when these two factors combined . Conclusions: Increased plasma Angptl7 and decreased plasma Fet-A levels are all linked with CHD in T2DM. The combination of Fet-A and Angptl7 possess better diagnostic value for CHD. Therefore, plasma Angptl7 and Fet-A might be promising for diagnosis of CHD in T2DM.

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Correlations of plasma angiopoietin-like 7, fetuin-A levels with coronary heart disease in patients with type 2 diabetes mellitus

Xue,

Tian,

et al. 2023

Preprint

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The impact of fetuin-A on predicting aortic arch calcification: secondary analysis of a community-based survey

Lin,

Shi

et al. 2024

Front. Cardiovasc. Med.

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IntroductionAtherosclerotic cardiovascular disease is associated with a high mortality rate due to vascular calcification. The role of fetuin-A in aortic arch calcification (AAC) is less well understood.MethodsAn analysis of secondary biomarkers was performed on 800 individuals from the biobank using the community database. AAC was defined by radiologists based on imaging. Multiple variables logical analysis was used for risk analysis.ResultsA total of 736 individual samples were collected based on age and gender. The average age is 65 ± 10 years, and half the population comprises men. In spite of similar body weight, renal function, and hepatic function, the AAC group had higher blood pressure and fetuin-A levels independently: systolic blood pressure (SBP) index ≥130 mmHg [adjusted odds ratio (aOR) 1.85, 95% confidence interval (CI) 1.34–2.57, p = 0.002] and fetuin-A (aOR 0.62, 95% CI 0.50–0.76, p < 0.001). Moreover, it is evident that AAC can be predicted more accurately when combined with SBP ≥130 mmHg and a low fetuin-A level (<358 μg/ml: aOR 5.39, 95% CI 3.21–9.08) compared with the reference.ConclusionLow fetuin-A levels are significantly correlated with AAC while there is an increased association between vascular calcification and coexisting hypertension.

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aveExpression of mir-29a-5p, sclerostin and fetuin-A in patients with chronic kidney disease and their correlation with vascular calcification

Cited by 2 publications

References 16 publications

Correlations of plasma angiopoietin-like 7, fetuin-A levels with coronary heart disease in patients with type 2 diabetes mellitus

Correlations of plasma angiopoietin-like 7, fetuin-A levels with coronary heart disease in patients with type 2 diabetes mellitus

The impact of fetuin-A on predicting aortic arch calcification: secondary analysis of a community-based survey

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