Average annual cost of Parkinson's disease in a Brazilian multiethnic population

Bovolenta, Tânia Maria; Schumacher-Schuh, Artur F.; Santos-Lobato, Bruno Lopes dos; Godeiro Júnior, Clécio de Oliveira; Silva, Delson José da; Nicaretta, Denise; Barbosa, Egberto R.; Cardoso, Francisco E.C.; Della Coletta, Marcus Vinicius; Braga Neto, Pedro; Cury, Rubens G.; Tumas, Vitor; Felicio, Andre C.

doi:10.1016/j.parkreldis.2023.105897

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2024

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Cited by 2 publications

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Prevalence, Distribution and Future Projections of Parkinson Disease in Brazil: Insights from the ELSI-Brazil Study

Hugentobler Schlickmann,

Somma Tessari,

Borelli

et al. 2024

Preprint

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Prevalence, Distribution and Future Projections of Parkinson Disease in Brazil: Insights from the ELSI-Brazil Study

Hugentobler Schlickmann,

Somma Tessari,

Borelli

et al. 2024

Preprint

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Computational Insights into the Interaction between Neprilysin and α-Bisabolol: Proteolytic Activity against Beta-Amyloid Aggregates in Alzheimer’s Disease

Martins,

da Cruz Freire,

Vasconcelos-Filho

et al. 2024

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(1) Background: Alzheimer’s disease (AD) is an irreversible disorder of the central nervous system associated with beta-amyloid protein (Aβ) deposition and accumulation. Current treatments can only act on symptoms and not the etiologic agent. Neprilysin and α-bisabolol have been shown to reduce the aggregation of Aβ, suggesting a potential interaction between both molecules, leading to increased proteolytic activity on Aβ aggregates. (2) Methods: Computational simulations were conducted to explore the interaction between murine neprilysin [NEP(m)] and α-bisabolol and their effects on enzymatic activity. NEP(m) structure was predicted using comparative modeling, and the binding pattern to α-bisabolol and its effects on leu-enkephalin binding were explored through docking calculations and molecular dynamics simulations, respectively. (3) Results: The findings suggest that α-bisabolol stabilizes the Val481-Pro488 segment of NEP2(m), which directly interacts with the peptide substrate, enabling an optimized alignment between the catalytic residue Glu525 and leu-enkephalin. (4) Conclusions: This computational evidence strongly supports the notion that α-bisabolol stabilizes peptide substrates at the NEP2(m) catalytic site, leading to the positive modulation of enzymatic activity.

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Average annual cost of Parkinson's disease in a Brazilian multiethnic population

Cited by 2 publications

References 10 publications

Prevalence, Distribution and Future Projections of Parkinson Disease in Brazil: Insights from the ELSI-Brazil Study

Prevalence, Distribution and Future Projections of Parkinson Disease in Brazil: Insights from the ELSI-Brazil Study

Computational Insights into the Interaction between Neprilysin and α-Bisabolol: Proteolytic Activity against Beta-Amyloid Aggregates in Alzheimer’s Disease

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