Avermectins, praziquantel and levamisole have in vitro efficacy against <i>Neoechinorhynchus buttnerae </i>(Neoechinorhynchidae) in <i>Colossoma macropomum</i>: A Serrasalmidae from the Amazon

Oliveira, L. C.; Majolo, Cláudia; Brandão, Franmir Rodrigues; Farias, Caio Francisco Santana; Oliveira, Maria Inês Braga de; Santos, Welliton Bezerra dos; Monteiro, Patrícia Castro; Rocha, Maria Juliete Souza; Chagas, Edsandra Campos; Tavares‐Dias, Marcos

doi:10.1111/jfd.12980

Cited by 25 publications

(25 citation statements)

References 20 publications

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“…However, Oliveira et al . (2019) studied the effect of eight anthelmintic drugs (albendazole, levamisole, mebendazole, fenbendazole, emamectin benzoate, ivermectin, loperamide and praziquantel) against N. buttnerae due to its importance in aquaculture in South America. It is known that the use of these substances depends on the approval and regulation, following the rules of each country.…”

Section: Discussionmentioning

confidence: 99%

Effect of nutraceuticals on acanthocephalan Neoechinorhynchus buttnerae and its toxicity to the host tambaqui Colossoma macropomum

et al. 2019

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The production of tambaqui Colossoma macropomum has been undergoing financial losses due to parasitic infection by the acanthocephalan Neoechinorhynchus buttnerae, raising an alert for aquaculture in South America. The lack of adequate treatment and use of unlicensed chemicals encourages research for alternative solutions with minimal side effects. The objectives of this study were to evaluate the in vitro antiparasitic potential of commercial nutraceutical products (Natumix® and BioFish®) against N. buttnerae and to assess the respective in vivo toxic effects on the host tambaqui. For in vitro assays, parasitized fish were necropsied for acanthocephalans sampling. The parasites were exposed to three concentrations (0.078, 0.313 and 1.25 mg/ml) of each product, as well as controls (one without product and another with a solubilizer). For the in vivo acute toxicity test, juvenile fish (<0.1 g) were exposed to five increasing concentrations of each product. Mortality of tambaqui was recorded at 24, 48, 72 and 96 h. The estimated lethal concentration (LC) for 10, 50, 90 and 99% of fish was determined to classify the toxicity of the products on the target species. After in vitro efficacy tests, the highest concentrations (1.25 mg/ml) caused 100% mortality of the parasites in both products, but only Natumix® caused 100% mortality using the intermediate concentration (0.313 mg/ml) after 24 h. According to the acute toxicity result, the LC50 classified the nutraceutical products as slightly toxic for tambaqui. The tested products had a parasiticidal effect on N. buttnerae, and the toxicity test showed that both products have therapeutic potential when added to the diet.

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Section: Discussionmentioning

confidence: 99%

Effect of nutraceuticals on acanthocephalan Neoechinorhynchus buttnerae and its toxicity to the host tambaqui Colossoma macropomum

et al. 2019

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“…Furthermore, acanthocephalans quite regularly contribute to the parasite fauna in marine [23][24][25] and freshwater aquaculture [26][27][28][29], which results in growth retardation, weakening, and emaciation of fishes [30]. Thorny-headed worms are even regarded the main obstacle to successful aquaculture in some regions [14,[31][32][33][34][35][36]. Despite their importance as a pest, no nuclear genome of an acanthocephalan has yet been published, nor have previous studies comprehensively captured their transcriptome and proteome, including both sexes and developmental stages.…”

Section: Introductionmentioning

confidence: 99%

“…It is obvious that a better knowledge of the molecular basis of acanthocephalan pathogenicity might provide starting points for the development of new drugs to control them. In fact, due to their low specificity, the use of established anthelminthics poses risks for the environment and consumers [25,[37][38][39][40], a deficit that the alternatives proposed so far do not overcome [9,30,36,41].…”

Section: Introductionmentioning

confidence: 99%

The genome, transcriptome, and proteome of the fish parasite Pomphorhynchus laevis (Acanthocephala)

et al. 2020

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Thorny-headed worms (Acanthocephala) are endoparasites exploiting Mandibulata (Arthropoda) and Gnathostomata (Vertebrata). Despite their worldwide occurrence and economic relevance as a pest, genome and transcriptome assemblies have not been published before. However, such data might hold clues for a sustainable control of acanthocephalans in animal production. For this reason, we present the first draft of an acanthocephalan nuclear genome, besides the mitochondrial one, using the fish parasite Pomphorhynchus laevis (Palaeacanthocephala) as a model. Additionally, we have assembled and annotated the transcriptome of this species and the proteins encoded. A hybrid assembly of long and short reads resulted in a near-complete P. laevis draft genome of ca. 260 Mb, comprising a large repetitive portion of ca. 63%. Numbers of transcripts and translated proteins (35,683) were within the range of other members of the Rotifera-Acanthocephala clade. Our data additionally demonstrate a significant reorganization of the acanthocephalan gene repertoire. Thus, more than 20% of the usually conserved metazoan genes were lacking in P. laevis. Ontology analysis of the retained genes revealed many connections to the incorporation of carotinoids. These are probably taken up via the surface together with lipids, thus accounting for the orange coloration of P. laevis. Furthermore, we found transcripts and protein sequences to be more derived in P. laevis than in rotifers from Monogononta and Bdelloidea. This was especially the case in genes involved in energy metabolism, which might reflect the acanthocephalan ability to use the scarce oxygen in the host intestine for respiration and simultaneously carry out fermentation. Increased plasticity of the gene repertoire through the integration of foreign DNA into the nuclear genome seems to be another underpinning factor of the evolutionary success of acanthocephalans. In any case, energy-related genes and their proteins may be considered as candidate targets for the acanthocephalan control.

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“…Santos et al (2018) investigated the in vitro efficacy of four essential oils, and Piper hispidinervum showed higher parasite mortality for a shorter exposure time. Oliveira et al (2019) evaluated the in vitro efficacy of eight anthelmintic products, where 100 mg/L of emamectin benzoate, 300 mg/L of levamisole, 4.500 mg/L of ivermectin, and 2.500 mg/L of praziquantel were shown to be effective. Despite these promising results, studies are needed to assess the pharmacokinetics and pharmacodynamics of these products, in addition to the impact of the costs of implementing medications in fish feed, and the effects of the drug on the palatability of a medicated diet for tambaqui.…”

Section: Use Of Chemotherapy and Herbal Medicinesmentioning

confidence: 99%

Occurrence, pathogenicity, and control of acanthocephalosis caused by Neoechinorhynchus buttnerae: A review

Castro

Jerônimo

Silva

et al. 2020

Rev. Bras. Parasitol. Vet.

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Infections negatively influence the production of tambaqui, and in north Brazil, the wide distribution of this parasitic disease has generated concern among fish farmers. The objective of this study was to review published literature on this pathogen. Six main online research databases were searched using the keywords “Neoechinorhynchus buttnerae”, “acantocefalose”, and “acanthocephalan fish”. Based on a set of predetermined criteria, 39 publications were selected for this review. The mechanism of pathogenic action of N. buttnerae is related to the degree of penetration of the proboscis. Infection results in histopathological and morphological changes in the host. The recurrence of the parasite in the northern region was greater twelve years after their first occurrence. The lack of specific legislation on veterinary products for aquatic animals, combined with the neglect of good management practices, and the absence of a contingency plan for the control of acanthocephalan infections have contributed to the current health situation of Colossoma macropomum northern Brazil. Additional information about the occurrence of the disease, pathogenicity, and control of acanthocephalan infections are imperative for developing a disease contingency plan in the region and research to address these should be encouraged by the sector.

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Avermectins, praziquantel and levamisole have in vitro efficacy against Neoechinorhynchus buttnerae (Neoechinorhynchidae) in Colossoma macropomum: A Serrasalmidae from the Amazon

Cited by 25 publications

References 20 publications

Effect of nutraceuticals on acanthocephalan Neoechinorhynchus buttnerae and its toxicity to the host tambaqui Colossoma macropomum

Effect of nutraceuticals on acanthocephalan Neoechinorhynchus buttnerae and its toxicity to the host tambaqui Colossoma macropomum

The genome, transcriptome, and proteome of the fish parasite Pomphorhynchus laevis (Acanthocephala)

Occurrence, pathogenicity, and control of acanthocephalosis caused by Neoechinorhynchus buttnerae: A review

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