Avian coccidiosis: changes in intestinal lymphocyte populations associated with the development of immunity to <i>Eimeria maxima</i>

Rothwell, Lisa; Gramzinski, Robert A.; Rose, Mark; Kaiser, Pete

doi:10.1111/j.1365-3024.1995.tb00883.x

Cited by 63 publications

(32 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gut infiltration by γδTCR + T cells was also observed in primary avian and murine Eimeria infections (Findly et al 1993;Rothwell et al 1995). Considering that these cells contribute to 40% or more of PBMC in young calves (Wilson et al 1996) this cell type may be of particular importance in cattle.…”

Section: Discussionmentioning

confidence: 87%

“…According to these (Rothwell et al 1995;Shi et al 2001;Vervelde et al 1996), immunohistological analyses of parasitized gut mucosa revealed infiltration of CD4 + T cells early after infection (8 days p. i.)…”

Section: Discussionmentioning

confidence: 99%

“…However, lymphocytes of E. bovis infected animals displayed enhanced antigen-specific proliferative activities (Hermosilla et al 1999;Hughes et al 1988;Hughes et al 1989), whilst non-specific reactions towards a mitogen seemed not influenced by infection (Hermosilla et al 1999). Data generated in rodent models or avian eimeriosis showed gut infiltration with both αβTCR + T cells (Lillehoj 1994;Rothwell et al 1995;Vervelde et al 1996) and γδTCR + T cells (Findly et al 1993;Rothwell et al 1995). Studies with αβTCR T cell deficient animals reveal these T cells as key actors (Roberts et al 1996;Smith and Hayday 2000b), whilst γδTCR + T cells seem of minor importance in the development of immunity (Roberts et al 1996;Rose et al 1996).…”

Section: Introductionmentioning

confidence: 93%

See 2 more Smart Citations

T cell reactions of Eimeria bovis primary- and challenge-infected calves

et al. 2010

View full text Add to dashboard Cite

Eimeria bovis infections commonly have clinical impact only on young animals, as homologous reinfections generally are under immunological control. So far, the nature of the immune responses delivering protection to calves has not been investigated. In this study we therefore analysed local and peripheral proliferative T cell activities of primary and challenge-infected calves and investigated the occurrence of T cell phenotypes in the peripheral blood and in mucosal gut segments isolated either by bioptic means or by necropsies.We show that lymphocytes of E. bovis-infected calves exhibit effective, transient antigen-specific proliferative responses in the course of prepatency of primary infection but fail to react after homologous reinfection suggesting early abrogation of parasite development. Whilst in primary infection an expansion of peripheral CD4+ T cells was observed, reinfection had no effect on the proportions of CD4+, CD8+ subsets or gammadeltaTCR+ T cells. In contrast, both E. bovis primary and challenge infections had an impact on local tissue T cell distribution. Primary infection was characterised by a CD4+ T cell infiltration early in prepatency in ileum and later in colon mucosa, whereas CD8+ T cells were only found accumulating in the latter gut segment. Challenge infection led to infiltration of both CD4+ and CD8+ T cells in small intestine and large intestine segments indicating protective functions of both cell types. In contrast, infiltration of ileum and colon mucosa with gammadeltaTCR+ T cells was restricted to primary infection.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

T cell reactions of Eimeria bovis primary- and challenge-infected calves

et al. 2010

View full text Add to dashboard Cite

show abstract

“…In chickens, the gutassociated lymphoid tissue (GALT) is responsible for inducing immune responses against bacterial, viral, and parasitic enteral antigens as well as responses to innocuous antigens [11][12][13][14][15]. In the cecal tonsil (CT), the largest lymphoid organ of the avian GALT, which both T and B cells, are present in germinal centers [16].…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Vanadium on Cecal Tonsil T Cell Subsets and IL-2 Contents in Broilers

Deng

Cui

Peng

et al. 2011

Biol Trace Elem Res

View full text Add to dashboard Cite

The purpose of this 42-day study was to investigate the effects of dietary excess vanadium on intestinal immune function by histopathological observation of cecal tonsil and changes of the cecal tonsil T cell subsets by method of flow cytometry. Four hundred twenty 1-day-old avian broilers were divided into six groups and fed on a corn-soybean basal diet as control diet or the same diet amended to contain 5, 15, 30, 45, and 60 mg/kg vanadium supplied as ammonium metavanadate. In comparison with those of control group, lymphocytes in the lymphatic nodule of cecal tonsil were apparently decreased in 45 and 60 mg/kg groups. The percentage of CD(3)(+) T cells was decreased (p < 0.05) in 45 mg/kg group at 28 and 42 days of age and significantly decreased (p < 0.01) in 60 mg/kg group at 28 and 42 days of age. The percentages of CD(3)(+)CD(4)(+) and CD(3)(+)CD(8)(+) T cells were markedly decreased (p < 0.05 or p < 0.01) in 60 mg/kg group from 14 to 28 days of age and were decreased (p < 0.05) in 45 mg/kg group at 28 and 42 days of age. However, changes of the CD(4)(+)/CD(8)(+) ratio were not significant. Meanwhile, the cecal tonsil interleukin-2 (IL-2) contents were decreased (p < 0.05 or p < 0.01) in 45 and 60 mg/kg groups from 14 to 42 days of age. It was concluded that dietary vanadium in excess of 30 mg/kg reduced the percentages of cecal tonsil T cells subsets and IL-2 contents, and caused cecal tonsil lesions, which impaired cecal tonsil function and impacted the local mucosal immune function of the intestines in broilers.

show abstract

“…Extrathymic CD4 þ CD8 þ T cells in pigs increase with age and are considered to be mature antigen-experienced memory/ effector cells (Pescovitz et al, 1994;Zuckermann & Husmann, 1996). The levels of ªä T cells increase in response to a variety of infections in different species such as mice (Hiromatsu et al, 1992), young cattle (Koets et al, 2002), chickens (Rothwell et al, 1995) and humans (Munk et al, 1990). These cells are considered important in the early response against infections at epithelial surfaces (Skeen & Ziegler, 1993;Boismenu & Havran, 1994;Ishigami et al, 1999) and in the immune response of young pigs before maturation of other lymphocyte subsets (Yang & Parkhouse, 1996).…”

Section: Numbers Of Circulating Cd4mentioning

confidence: 99%

Differences in lymphocyte subpopulations and cell counts before and after experimentally induced swine dysentery

Jonasson

Johannisson

Jacobson

et al. 2004

Journal of Medical Microbiology

View full text Add to dashboard Cite

The aim of this study was to examine the levels of circulating leukocytes and lymphocyte subpopulations before and immediately after experimentally induced swine dysentery. Twenty-one healthy crossbred pigs ($22 kg) were orally inoculated with Brachyspira hyodysenteriae. Blood was sampled before inoculation and when clinical signs of swine dysentery occurred. Pigs that remained healthy were sampled when killed. Total and differential white blood cell counts were performed, and lymphocyte subpopulations were analysed using flow cytometry. Following a mean incubation period of 13 days, 12 pigs developed swine dysentery, whereas nine remained healthy throughout the study. Before inoculation, pigs that subsequently developed swine dysentery displayed higher levels of circulating ªä T cells (mean AE SE; 30 . 7 AE 3 . 5 %) compared with pigs that remained healthy (14 . 9 AE 1 . 4 %). Sick animals also displayed lower levels of CD8 þ cells (24 . 6 AE 1 . 5 %), cytotoxic/suppressor T cells (10 . 9 AE 1 . 3 %) and CD4 þ CD8 À T cells (8 . 1 AE 1 . 0 %) than the pigs that remained healthy (34 . 9 AE 3 . 1 %; 17 . 6 AE 2 . 0 %; 13 . 6 AE 2 . 3 %). No difference was observed in leukocyte counts before inoculation. At onset of swine dysentery, there was an increase in monocytes (from 1 . 5 AE 0 . 2 3 10 9 to 3 . 8 AE 0 . 5 3 10 9 l À1 ) and CD4 þ CD8 þ T cells (from 5 . 8 AE 0 . 9 to 8 . 9 AE 0 . 7 %). In conclusion, ªä T cells and CD8 þ cells may be associated with susceptibility to experimentally induced swine dysentery, whereas monocytes and CD4 þ CD8 þ T cells appear to be the major responding leukocytes during the disease.

show abstract

Avian coccidiosis: changes in intestinal lymphocyte populations associated with the development of immunity to Eimeria maxima

Cited by 63 publications

References 33 publications

T cell reactions of Eimeria bovis primary- and challenge-infected calves

T cell reactions of Eimeria bovis primary- and challenge-infected calves

Effect of Dietary Vanadium on Cecal Tonsil T Cell Subsets and IL-2 Contents in Broilers

Differences in lymphocyte subpopulations and cell counts before and after experimentally induced swine dysentery

Contact Info

Product

Resources

About