2014
DOI: 10.1074/jbc.m113.522003
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Avian Facial Morphogenesis Is Regulated by c-Jun N-terminal Kinase/Planar Cell Polarity (JNK/PCP) Wingless-related (WNT) Signaling

Abstract: Background:Numerous genes contribute to the increased risk of facial clefting, but the cellular mechanisms involved are not well understood. Results: JNK/PCP wingless-related signaling is demonstrated as a major regulator of face shape. Conclusion: WNT11 induces clefting via inhibiting proliferation, compressing facial prominences, and changing cell behavior. Significance: JNK/PCP WNT signaling is implicated in the pathophysiology underlying craniofacial abnormalities.

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Cited by 31 publications
(57 citation statements)
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“…S6). This reporter was activated by LiCl as shown previously (Geetha-Loganathan et al, 2014;Hosseini-Farahabadi et al, 2013). Significant activation by Noggin was observed at certain concentrations but not by RA (Fig.…”
Section: Cross Talk Between Noggin Ra and Wnt Pathwaysmentioning
confidence: 57%
“…S6). This reporter was activated by LiCl as shown previously (Geetha-Loganathan et al, 2014;Hosseini-Farahabadi et al, 2013). Significant activation by Noggin was observed at certain concentrations but not by RA (Fig.…”
Section: Cross Talk Between Noggin Ra and Wnt Pathwaysmentioning
confidence: 57%
“…This intricate signaling crosstalk coordinates the convergent growth and morphogenesis of the facial prominences that is essential for aligning these structures prior to fusion (e.g. Geetha-Loganathan et al, 2014; Green et al, 2015; Hu et al, 2015; Linde-Medina et al, 2016; Suzuki et al, 2016). Subsequent interactions between the apposed epithelia then consummate lip and palate fusion (reviewed in Kousa and Schutte, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…Pharyngeal endoderm, and neural and non‐neural ectoderm function as key epithelial signaling centers by releasing complex combinations of secreted molecules from well‐characterized pathways including Bone Morphogenetic Protein (BMP), Sonic Hedgehog (SHH), Fibroblast Growth Factor (FGF), and Wingless‐Related (WNT) that are indispensable to the proper patterning and differentiation of neural crest mesenchyme (Alvarado‐Mallart, ; Anderson, Lawrence, Stottmann, Bachiller, & Klingensmith, ; Barlow & Francis‐West, ; Benouaiche, Gitton, Vincent, Couly, & Levi, ; Cela et al, ; Crump et al, ; Ekker et al, ; Francis‐West, Ladher, Barlow, & Graveson, ; Gitton et al, ; Graham, ; Marcucio et al, ; Marcucio, Young, Hu, & Hallgrimsson, ; Pera, Stein, & Kessel, ; Piotrowski & Nusslein‐Volhard, ; Sasai & De Robertis, ; Schneider, Hu, Rubenstein, Maden, & Helms, ; Shimamura, Hartigan, Martinez, Puelles, & Rubenstein, ; Veitch et al, ; Wilson & Tucker, ; Withington, Beddington, & Cooke, ; Xu et al, ). Various members and targets of these pathways also become differentially regulated not only as a mechanism to support the outgrowth of the jaw and facial skeletons (Abzhanov & Tabin, ; Ashique, Fu, & Richman, ; Chong et al, ; Cordero, Schneider, & Helms, ; Couly et al, ; Doufexi & Mina, ; Geetha‐Loganathan, Nimmagadda, Fu, & Richman, ; Havens et al, ; Helms & Schneider, ; Hu, Colnot, & Marcucio, ; Hu et al, ; Liu et al, ; MacDonald, Abbott, & Richman, ; Melnick, Witcher, Bringas, Carlsson, & Jaskoll, ; Miller et al, ; Mina, Wang, Ivanisevic, Upholt, & Rodgers, ; Nimmagadda et al, ; Richman, Herbert, Matovinovic, & Walin, ; Rowe, Richman, & Brickell, ; Schneider, Hu, & Helms, ; Schneider et al, ; Szabo‐Rogers, Geetha‐Loganathan, Nimmagadda, Fu, & Richman, ; Wada et al, ; Young, Chong, Hu, Hallgrimsson, & Marcucio, ) but also as a component of regulating species‐specific size and shape (Abramyan, Leung, &...…”
Section: Origin Of Species‐specific Versus Species‐generic Aspects Ofmentioning
confidence: 99%
“…Benouaiche, Gitton, Vincent, Couly, & Levi, 2008;Cela et al, 2016;Crump et al, 2004;Ekker et al, 1995;Francis-West, Ladher, Barlow, & Graveson, 1998;Gitton et al, 2010;Graham, 2003;Marcucio et al, 2005;Marcucio, Young, Hu, & Hallgrimsson, 2011;Pera, Stein, & Kessel, 1999;Piotrowski & Nusslein-Volhard, 2000;Sasai & De Robertis, 1997;Schneider, Hu, Rubenstein, Maden, & Helms, 2001;Shimamura, Hartigan, Martinez, Puelles, & Rubenstein, 1995;Veitch et al, 1999;Wilson & Tucker, 2004;Withington, Beddington, & Cooke, 2001;Xu et al, 2015). Various members and targets of these pathways also become differentially regulated not only as a mechanism to support the outgrowth of the jaw and facial skeletons Ashique, Fu, & Richman, 2002a;Chong et al, 2012;Cordero, Schneider, & Helms, 2002;Couly et al, 2002;Doufexi & Mina, 2008;Geetha-Loganathan, Nimmagadda, Fu, & Richman, 2014;Havens et al, 2008;Hu, Colnot, & Marcucio, 2008;Hu et al, 2003;Liu et al, 2005;MacDonald, Abbott, & Richman, 2004;Melnick, Witcher, Bringas, Carlsson, & Jaskoll, 2005;Miller et al, 2000;Mina, Wang, Ivanisevic, Upholt, & Rodgers, 2002;Nimmagadda et al, 2015;Richman, Herbert, Matovinovic, & Walin, 1997;…”
Section: Origin Of Species-specific Versus Species-generic Aspects mentioning
confidence: 99%