Avian paramyxovirus 4 isolated from the mallard (&lt;i&gt;Anas platyrhynchos&lt;/i&gt;, Linnaeus, 1758): the first case detected in the Western Caspian region

Derko, Anastasiya; Dubovitskiy, Nikita; Murashkina, Tatyana; Sobolev, Ivan; Соломатина, М. В.; Alekseev, Alexander; Magomedov, M. G.; Mine, Junki; Uchida, Yu; Saito, Takehiko; Kallaeva, M. M.; Sharshov, Kirill

doi:10.18470/1992-1098-2021-3-81-87

Cited by 2 publications

(4 citation statements)

References 13 publications

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“…From the partial sequences we obtained of our coronaviruses, we constructed a phylogenetic tree by comparing the partial sequences of the RdRp with those in the GenBank database ( Figure 3 ). The results showed that gammacoronaviruses are mainly clustered with duck and shorebird ACoVs mainly found in different countries of Europe and Asia, including viruses currently found in Siberia [ 16 ]. One isolate had relation to the cluster of American and Australian wild duck ACoVs.…”

Section: Discussionmentioning

confidence: 99%

“…However, it should be noted that this species constituted the largest number in terms of sample size. Earlier, our research revealed a high percentage of influenza A viruses and avian paramyxoviruses, but ACoV was not included in the studies [13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

“…The role of infected but asymptomatic wild migrating birds in the dissemination of viruses over long distances was first described at the beginning of the 1970s when avian influenza A viruses (AIV) and avian paramyxoviruses (subfamily Avulavirinae, family Paramyxoviridae) (APMV used hereafter for the purposes of this paper) in wild waterfowl were described in multiple publications, including active surveillance in Russia [9][10][11][12][13][14][15][16]. The probability of new zoonotic variants intruding into the human population raises concerns following the history of previous influenza pandemics and recent sporadic fatal cases of avian influenza in humans [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Does Avian Coronavirus Co-Circulate with Avian Paramyxovirus and Avian Influenza Virus in Wild Ducks in Siberia?

Sharshov

Dubovitskiy

Derko

et al. 2023

Viruses

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Avian coronaviruses (ACoV) have been shown to be highly prevalent in wild bird populations. More work on avian coronavirus detection and diversity estimation is needed for the breeding territories of migrating birds, where the high diversity and high prevalence of Orthomyxoviridae and Paramyxoviridae have already been shown in wild birds. In order to detect ACoV RNA, we conducted PCR diagnostics of cloacal swab samples from birds, which we monitored during avian influenza A virus surveillance activities. Samples from two distant Asian regions of Russia (Sakhalin region and Novosibirsk region) were tested. Amplified fragments of the RNA-dependent RNA-polymerase (RdRp) of positive samples were partially sequenced to determine the species of Coronaviridae represented. The study revealed a high presence of ACoV among wild birds in Russia. Moreover, there was a high presence of birds co-infected with avian coronavirus, avian influenza virus, and avian paramyxovirus. We found one case of triple co-infection in a Northern Pintail (Anas acuta). Phylogenetic analysis revealed the circulation of a Gammacoronavirus species. A Deltacoronavirus species was not detected, which supports the data regarding the low prevalence of deltacoronaviruses among surveyed bird species.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Does Avian Coronavirus Co-Circulate with Avian Paramyxovirus and Avian Influenza Virus in Wild Ducks in Siberia?

Sharshov

Dubovitskiy

Derko

et al. 2023

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“…In addition to influenza A viruses, there are other viruses associated with wild waterfowl. These are the avian paramyxoviruses (APMVs) belonging to subfamily Avulavirinae, order Paramyxoviridae [ 1 ], the first detection of which was in the Caspian region, where avian paramyxovirus APMV-4 was discovered in the western middle Caspian littoral [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Avian Influenza Virus and Avian Paramyxoviruses in Wild Waterfowl of the Western Coast of the Caspian Sea (2017–2020)

Murashkina,

Sharshov,

Gadzhiev

et al. 2024

Viruses

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The flyways of many different wild waterfowl pass through the Caspian Sea region. The western coast of the middle Caspian Sea is an area with many wetlands, where wintering grounds with large concentrations of birds are located. It is known that wild waterfowl are a natural reservoir of the influenza A virus. In the mid-2000s, in the north of this region, the mass deaths of swans, gulls, and pelicans from high pathogenicity avian influenza virus (HPAIV) were noted. At present, there is still little known about the presence of avian influenza virus (AIVs) and different avian paramyxoviruses (APMVs) in the region’s waterfowl bird populations. Here, we report the results of monitoring these viruses in the wild waterfowl of the western coast of the middle Caspian Sea from 2017 to 2020. Samples from 1438 individuals of 26 bird species of 7 orders were collected, from which 21 strains of AIV were isolated, amounting to a 1.46% isolation rate of the total number of samples analyzed (none of these birds exhibited external signs of disease). The following subtypes were determined and whole-genome nucleotide sequences of the isolated strains were obtained: H1N1 (n = 2), H3N8 (n = 8), H4N6 (n = 2), H7N3 (n = 2), H8N4 (n = 1), H10N5 (n = 1), and H12N5 (n = 1). No high pathogenicity influenza virus H5 subtype was detected. Phylogenetic analysis of AIV genomes did not reveal any specific pattern for viruses in the Caspian Sea region, showing that all segments belong to the Eurasian clades of classic avian-like influenza viruses. We also did not find the amino acid substitutions in the polymerase complex (PA, PB1, and PB2) that are critical for the increase in virulence or adaptation to mammals. In total, 23 hemagglutinating viruses not related to influenza A virus were also isolated, of which 15 belonged to avian paramyxoviruses. We were able to sequence 12 avian paramyxoviruses of three species, as follows: Newcastle disease virus (n = 4); Avian paramyxovirus 4 (n = 5); and Avian paramyxovirus 6 (n = 3). In the Russian Federation, the Newcastle disease virus of the VII.1.1 sub-genotype was first isolated from a wild bird (common pheasant) in the Caspian Sea region. The five avian paramyxovirus 4 isolates obtained belonged to the common clade in Genotype I, whereas phylogenetic analysis of three isolates of Avian paramyxovirus 6 showed that two isolates, isolated in 2017, belonged to Genotype I and that an isolate identified in 2020 belonged to Genotype II. The continued regular monitoring of AIVs and APMVs, the obtaining of data on the biological properties of isolated strains, and the accumulation of information on virus host species will allow for the adequate planning of epidemiological measures, suggest the most likely routes of spread of the virus, and assist in the prediction of the introduction of the viruses in the western coastal region of the middle Caspian Sea.

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Avian paramyxovirus 4 isolated from the mallard (<i>Anas platyrhynchos</i>, Linnaeus, 1758): the first case detected in the Western Caspian region

Cited by 2 publications

References 13 publications

Does Avian Coronavirus Co-Circulate with Avian Paramyxovirus and Avian Influenza Virus in Wild Ducks in Siberia?

Does Avian Coronavirus Co-Circulate with Avian Paramyxovirus and Avian Influenza Virus in Wild Ducks in Siberia?

Avian Influenza Virus and Avian Paramyxoviruses in Wild Waterfowl of the Western Coast of the Caspian Sea (2017–2020)

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