Avian Physiology: Are Birds Simply Feathered Mammals?

Scanes, Colin G.

doi:10.3389/fphys.2020.542466

Cited by 12 publications

(12 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This glutamic acid is not found in orthologs with both cysteines. The distinct evolutionary bifurcation of the ZG16 carboxy‐terminal tail, as well as the apparent absence of the protein in birds (which have evolved unique aspects of their digestive systems [ 35 ]), may provide hints to the physiological role of ZG16.…”

Section: Discussionmentioning

confidence: 99%

Conformational switches and redox properties of the colon cancer‐associated human lectin ZG16

et al. 2021

View full text Add to dashboard Cite

Zymogen granule membrane protein 16 (ZG16) is produced in organs that secrete large quantities of enzymes and other proteins into the digestive tract. ZG16 binds microbial pathogens, and lower ZG16 expression levels correlate with colorectal cancer, but the physiological function of the protein is poorly understood. One prominent attribute of ZG16 is its ability to bind glycans, but other aspects of the protein may also contribute to activity. An intriguing feature of ZG16 is a CXXC motif at the carboxy terminus. Here, we describe crystal structures and biochemical studies showing that the CXXC motif is on a flexible tail, where it contributes little to structure or stability but is available to engage in redox reactions. Specifically, we demonstrate that the ZG16 cysteine thiols can be oxidized to a disulfide by quiescin sulfhydryl oxidase 1, which is a sulfhydryl oxidase present together with ZG16 in the Golgi apparatus and in mucus, as well as by protein disulfide isomerase. ZG16 crystal structures also draw attention to a nonproline cis peptide bond that can isomerize within the protein and to the mobility of glycine-rich loops in the glycan-binding site. An understanding of the properties of the ZG16 CXXC motif and the discovery of internal conformational switches extend existing knowledge relating to the glycan-binding activity of the protein.

show abstract

Section: Discussionmentioning

confidence: 99%

Conformational switches and redox properties of the colon cancer‐associated human lectin ZG16

et al. 2021

View full text Add to dashboard Cite

show abstract

“…An alternative explanation for the observed differences in seroreactivity of a subset of the C. psittaci peptides may be the dissimilarity of immune systems of mammals and birds, including differences in antibody development and antigen processing [ 27 – 29 ]; mice and birds may recognize different epitopes. This speculation is fed by two observations.…”

Section: Discussionmentioning

confidence: 99%

Proof of concept for multiplex detection of antibodies against Chlamydia species in chicken serum using a bead-based suspension array with peptides as antigens

Wal

Achterberg

Goot

et al. 2023

Vet Res

View full text Add to dashboard Cite

The available differentiating tests for Chlamydia are based on detection of genetic material and only give information about the actual infection status, but reveal nothing of past infections. As the use of serological methods increases the window of detection, the goal of this study was to investigate if it is possible to develop a differentiating serological test for antibodies against Chlamydia species in chicken sera. Focus was on C. psittaci, C. gallinacea, and two closely related species, i.e. C. abortus and C. avium. To enable differentiating serology, a bead-based Luminex suspension array was constructed, using peptides as antigens, derived from known immunoreactive Chlamydia proteins. For the majority of these peptides, species-specific seroreactivity in mammalian sera has been reported in literature. The suspension array correctly identified antibodies against various Chlamydia species in sera from experimentally infected mice, and was also able to differentiate between antibodies against C. psittaci and C. gallinacea in sera from experimentally infected chickens. In field sera, signals were difficult to interpret as insufficient sera from experimentally infected chickens were available for evaluating the seroreactivity of all peptides. Nevertheless, results of the suspension array with field sera are supported by published data on the occurrence of C. gallinacea in Dutch layers, thereby demonstrating the proof of concept of multiplex serology for Chlamydial species in poultry.

show abstract

“…In the current study, SYN supplemented birds had a higher relative spleen weight compared with both BMD and CON birds on d 42 under TN condition. The spleen is a major immune organ in birds, and weight changes have been used as an indicator of immunity in response to stress ( Scanes, 2020 ). Greater relative spleen weight may indicate an enhanced immune response and lower stress reaction in broilers fed with the SYN supplements.…”

Section: Discussionmentioning

confidence: 99%

Effect of a synbiotic supplement as an antibiotic alternative on broiler skeletal, physiological, and oxidative parameters under heat stress

Mohammed

Murugesan³

et al. 2022

Poultry Science

View full text Add to dashboard Cite

Avian Physiology: Are Birds Simply Feathered Mammals?

Cited by 12 publications

References 116 publications

Conformational switches and redox properties of the colon cancer‐associated human lectin ZG16

Conformational switches and redox properties of the colon cancer‐associated human lectin ZG16

Proof of concept for multiplex detection of antibodies against Chlamydia species in chicken serum using a bead-based suspension array with peptides as antigens

Effect of a synbiotic supplement as an antibiotic alternative on broiler skeletal, physiological, and oxidative parameters under heat stress

Contact Info

Product

Resources

About