1963
DOI: 10.1016/s0065-230x(08)60982-3
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Avian Virus Growths and their Etiologic Agents

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Cited by 120 publications
(39 citation statements)
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“…The virion was collected from the top of the glycerol pad and diluted with 0.1 M NaCl-1 mM Tris (pH 7.4)-i mM EDTA. The virus was purified further after two cycles of differential centrifugation (17).…”
Section: Methodsmentioning
confidence: 99%
“…The virion was collected from the top of the glycerol pad and diluted with 0.1 M NaCl-1 mM Tris (pH 7.4)-i mM EDTA. The virus was purified further after two cycles of differential centrifugation (17).…”
Section: Methodsmentioning
confidence: 99%
“…This property was developed into an end-point titration assay and hundreds of thousands of chickens were used to purify and study the virus (reviewed in Beard, 1963). Following the introduction of a cell culture assay for RSV by Rubin and Temin, similar assays were developed for AMV (Baluda and Goetz, 1961).…”
Section: Cells and Transformation Assays (Figure 2)mentioning
confidence: 99%
“…In particular, although both Rous sarcoma virus (RSV) and AMV could replicate in cultures of either embryonic ®broblasts or hematopoietic cells, RSV could transform only ®broblasts whereas AMV could transform only hematopoietic cells (Baluda, 1963;Durban and Boettiger, 1981a). Second, chickens infected with AMV develop remarkably high white counts and therefore their peripheral blood contains remarkably large quantities of viral particles (Beard, 1963). For this reason AMV was often used as a prototypic retrovirus in order to study viral assembly and later to produce large amounts of reverse transcriptase for both research and commercial purposes.…”
mentioning
confidence: 99%
“…Whereas the avian myeloblastosis virus (AMV) containing the v-myb oncogene exclusively induces myeloblastosis (1,17,18), E26 exhibits a dual-target cell specificity for hematopoietic cells and is able to transform both avian myeloblasts and erythroblasts in vitro. When inoculated into chickens, E26 induces a mixed erythroid-myeloid leukemia, although proliferation of erythroid elements predominates (10,11,18,24).…”
mentioning
confidence: 99%