Avocado Oil Attenuates Diethylnitrosamine Induced-Hepatic Carcinogenesis

Abo-Zaid, Omayma Ar; Aziza, Samy; Moawed, Fatma S M; Kasseb, S.G

doi:10.21608/bvmj.2018.96425

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…The anti-cancer effects of avocado seeds (lipid-rich extract) were reported in vitro against various types of cancer cell lines including Caco-2 (Lara-Márquez et al, 2020 ), HCT116, and HePG2 (Alkhalaf et al, 2019 ). Moreover, Abozaid et al ( 2018 ) stated in his preliminary study that avocado oil could be considered a promising therapeutic adjuvant against DEN-induced hepatocarcinogenesis. The protective anti-carcinogenic mechanisms of avocado hydroethanolic extracts in the DEN/2AAF-induced liver cancer model are not fully explored.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of Persea americana fruit and seed extracts against chemically induced liver cancer in rats by enhancing their antioxidant, anti-inflammatory, and apoptotic activities

Ahmed

Fahim

Mohamed

et al. 2022

Environ Sci Pollut Res

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This study aims to explore the chemopreventive mechanisms of hydroethanolic extracts from avocado (Persea Americana) in diethylnitrosamine (DEN)/2-acetylaminofluorene (2AAF)-induced hepatocarcinogenesis. Chemical induction of hepatocarcinogenesis was induced by intraperitoneal injection of DEN at 150 mg/kg body weight (b.w.) twice a week for a fortnight, followed by oral administration of 2AAF at 20 mg/kg b.w. four times a week for 3 weeks. Rats administered DEN/2AAF were orally treated with hydroethanolic extracts of avocado fruits and seeds at a dose of 50 mg/kg b.w. every other day for 20 weeks. Moreover, rats administered DEN/2AAF and treated with avocado extracts revealed a marked decrease in liver enzyme activities, total bilirubin levels, and elevated liver tumor markers, but revealed an increase in total protein and albumin levels. The hepatocytes with hyperchromatic and bile duct cystadenoma observed in the liver of rats administered DEN/2AAF were reduced due to treatment with avocado extracts. Furthermore, the treatments prevented the elevation of lipid peroxidation levels and ameliorated the lowered glutathione peroxidase, glutathione-S-transferase, superoxide dismutase activities, and glutathione content in the liver tissues. Also, antigen Ki-67, cyclooxygenase-2, and nuclear factor kappa-B expression levels were decreased, but of the suppressor proteins p53 and BAX levels were increased in the liver of rats administered DEN/2AAF and treated with avocado extracts. In conclusion, the current results demonstrated that avocado extracts could abate hepatocarcinogenesis in rats administered DEN/2AAF through activation of antioxidant, anti-inflammatory, and apoptotic properties.

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Section: Introductionmentioning

confidence: 99%

Protective effects of Persea americana fruit and seed extracts against chemically induced liver cancer in rats by enhancing their antioxidant, anti-inflammatory, and apoptotic activities

Ahmed

Fahim

Mohamed

et al. 2022

Environ Sci Pollut Res

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“…Group 1 (Negative control): Given distilled water (10ml/kg) for 7 days Group 2 (Positive control): Given Omeprazole (30mg/kg) for7 days Group 3 (Treatment group): Given Extra Virgin Avocado oil (1ml per 250g body weight) for 7 days [26]. Animals were fasted for 24 hours into the 8 th day before the ulcer induction.…”

Section: Experimental Designmentioning

confidence: 99%

Evaluation of the Anti-ulcer Effect of Extra Virgin Avocado (Persea americana) Oil in Rats

et al. 2022

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Peptic ulcer disease is a gastrointestinal disorder of high mortality and morbidity. Therapy of this disease condition with conventional drugs presents therapeutic challenge due to incidents of unwanted side effects, and the high cost of these medications. The use of products from natural sources will provide useful alternatives due to their minimal side effects, being inexpensive, and readily available, especially in resource-challenged nations of the continent of Africa and other developing economies. Oils derived from plants are increasingly being used in management of several disease conditions. This study aims at evaluating the antiulcer activity of extra virgin avocado oil in rodents using ethanol-induced, and indomethacin-induced ulcer models. Test group was given extra virgin avocado oil (1ml per 250g weight) for 7 days before induction of ulcer. Positive controls received omeprazole 30 mg/kg, while negative control animals were given distilled water (10ml/kg) for 7 days respectively, before induction of ulcer. The stomachs were excised and their histopathological examinations carried out. Avocado oil significantly reduced the ulcer index in both models when compared to the negative control group, and histopathological findings corroborate that the oil ameliorates ulcerations in both models. The present study has demonstrated that extra virgin avocado oil possesses significant antiulcer activity.

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“…Group 2 (Diabetic control): Diabetic rats given 10ml/kg/day of normal saline orally for 15 days. Group 3 (Avocado oil): Diabetic rats given extra virgin avocado oil 1ml/250g body weight orally for 15 days [34].…”

Section: Experimental Designmentioning

confidence: 99%

Hypoglycaemic Activity of Extra Virgin Avocado (Persea americana) Oil and Extra Virgin Coconut (Cocos nucifera) Oil on Alloxan-induced Diabetic Rats

Offor

Tologbonse

Iseh

et al. 2021

JOCAMR

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Diabetes mellitus is a chronic, metabolic disorder characterized by abnormal elevation of blood glucose levels (hyperglycaemia). Despite significant milestones achieved using conventional drugs in managing the disease, there are some drawbacks associated with their use such as drug resistance, adverse drug effects, high cost, and sometimes outright therapeutic failure. The urgent need to bridge this therapeutic lacuna calls for further exploration and investigation of other treatment options. This study therefore aims at evaluating the antidiabetic potentials of virgin avocado oil and virgin coconut oil in alloxan-induced diabetic rats. Animals were divided into 5 groups of five rats each. Group 1 (negative control) received 10 ml /kg/day of normal saline, group 2 (diabetic control) -10 ml/kg/day of normal saline; group 3 received extra virgin avocado oil (1 ml/250 g) body weight, group 4 received extra virgin coconut oil (2 ml/kg) bodyweight, and group 5 received 10 mg/kg/day of metformin. Treatments were administered orally for 15 days. Extra virgin avocado oil and extra virgin coconut oil respectively showed significant antidiabetic activities, and may be beneficial for management of diabetes mellitus.

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Avocado Oil Attenuates Diethylnitrosamine Induced-Hepatic Carcinogenesis

Cited by 5 publications

References 9 publications

Protective effects of Persea americana fruit and seed extracts against chemically induced liver cancer in rats by enhancing their antioxidant, anti-inflammatory, and apoptotic activities

Protective effects of Persea americana fruit and seed extracts against chemically induced liver cancer in rats by enhancing their antioxidant, anti-inflammatory, and apoptotic activities

Evaluation of the Anti-ulcer Effect of Extra Virgin Avocado (Persea americana) Oil in Rats

Hypoglycaemic Activity of Extra Virgin Avocado (Persea americana) Oil and Extra Virgin Coconut (Cocos nucifera) Oil on Alloxan-induced Diabetic Rats

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