Avocado paste from industrial byproducts as an unconventional source of bioactive compounds: characterization, in vitro digestion and in silico interactions of its main phenolics with cholesterol

Fasting alters p75NTR and AgRP mRNA expression in rat olfactory bulb and hippocampus

“…AVO pellets consisted of an avocado phenolic-rich extract obtained from avocado paste that was used to coat standard CP, at a dose of 100 µL per 5 g pellet (Corella-Salazar et al, 2021). The phenolic composition of the extract has been previously reported but, in brief, it contained ferulic acid > protocatechuic acid > p-coumaric acid > quercetin > kaempferol > gallic acid (Corella-Salazar et al, 2021;Zuñiga-Martínez et al, 2021). The extract was obtained by homogenizing avocado paste at 25 °C with 80% ethanol in 50 mL tubes, in a 1:20 (w/v) ratio.…”

“…For example, in vivo and in vitro studies have demonstrated that different phenolic compounds like catechin, epicatechin, chlorogenic acid, gallic acid, and procyanidins are able to modulate hunger and satiety mediators, including cholecystokinin, glucagon-like peptide-1, and leptin, which has made them subjects of study as anti-obesity agents (Singh et al, 2020). Moreover, bioactive phenolic compounds found in avocado paste (the industrial byproducts of its processing) include gallic acid, protocatechuic acid, p-coumaric acid, ferulic acid, quercetin, and kaempferol, among others (Zuñiga-Martínez et al, 2021). These have been shown to induce satiety effects and to decrease food intake in in vivo models, for example, Corella-Salazar et al, (2021) recently reported that consuming said phenolic-rich avocado paste extract induced glucagon-like peptide-1 and leptinmediated satiety effects in a murine model.…”