Avocado (Persea americana) fruit extract (2R,4R)-1,2,4-trihydroxyheptadec-16-yne inhibits dengue virus replication via upregulation of NF-κB–dependent induction of antiviral interferon responses

Abstract

Dengue virus (DENV) caused millions of infections around the world annually. Co-infection with different serotypes of DENV is associated with dengue hemorrhagic shock syndrome, leading to an estimate of 50% death rate. No approved therapies are currently available for the treatment of DENV infection. Hence, novel anti-DENV agents are urgently needed for medical therapy. Here we demonstrated that a natural product (2 R,4 R)-1,2,4-trihydroxyheptadec-16-yne (THHY), extracted from avocado (Persea americana) fruit, can inhibit DENV-2 replication in a concentration-dependent manner and efficiently suppresses replication of all DENV serotypes (1–4). We further reveal that the NF-κB-mediated interferon antiviral response contributes to the inhibitory effect of THHY on DENV replication. Using a DENV-infected ICR suckling mouse model, we found that THHY treatment caused an increased survival rate among mice infected with DENV. Collectively, these findings support THHY as a potential agent to control DENV infection.

Echinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat hypermethylated silencing of endogenous retroviral sequences

“…Altogether, the latter suggests that its immunomodulatory effects are due to the active compounds present in the formulation [ 12 , 19 ]. Similar activation of IFN innate immunity and viral protection has been observed in presence of avocado and apple extract [ 121 , 122 ]. Interestingly, in the latter case, effects were attributed to oligomeric proanthocyanidins and lost with their monomeric form [ 122 ].…”

The Odyssey of Bioactive Compounds in Avocado (Persea americana) and Their Health Benefits

“…In brief, fatty alcohols isolated from avocado showed different degrees of unsaturation and alkyl chain length with several levels of hydroxylation and subsequent acetylation (Figure 1). These fatty alcohols have been reported to exhibit antiviral, cytotoxic, antifungal, trypanocidal, and antioxidant activity [10,11,12,13,14,15,16,17,18,19,20,21]. Phenolic compounds (Figure 2, and Table 1) of different chemical classes from simple organic acids such as gallic acid to larger flavonoids, anthocyanidins, and tocopherols were isolated from Persea species with significant antioxidant, neuroprotective and cardioprotective activities [22,23,24,25,26,27,28].…”

Standardized Echinacea purpurea extract primes an IFN specific innate immune monocyte response via JAK1-STAT1 dependent gene expression and epigenetic control of endogenous retroviral sequences

“…Altogether, the latter suggests that its immunomodulatory effects are due to the active compounds present in the formulation [13,20]. Similar activation of IFN innate immunity and viral protection has been observed in presence of avocado and apple extract [100,101]. Interestingly, in the latter case, effects were attributed to oligomeric proanthocyanidins and lost with their monomeric form [101].…”